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A0Q7B4

- TYSY_FRATN

UniProt

A0Q7B4 - TYSY_FRATN

Protein

Thymidylate synthase

Gene

thyA

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei156 – 1561UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciFNOV401614:GC4M-1247-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:FTN_1248
    OrganismiFrancisella tularensis subsp. novicida (strain U112)
    Taxonomic identifieri401614 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000762: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Thymidylate synthasePRO_1000000600Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi401614.FTN_1248.

    Structurei

    3D structure databases

    ProteinModelPortaliA0Q7B4.
    SMRiA0Q7B4. Positions 2-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257899.
    KOiK00560.
    OMAiQCHEAIQ.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    A0Q7B4-1 [UniParc]FASTAAdd to Basket

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    MREYLNFLKY IKENGVLKGD RTGTGTRSIF GYQMRFDLQK GFPLVTTKKI    50
    HIPSVVHELL WFLSGSTNIK YLNDNNVRIW NEWATVDGEL GPIYGKQWRD 100
    FNGQGIDQIA DVIQMLKTNP NSRRILVSAW NPCVVPSEKI SPQENVVKGN 150
    SALPPCHAMF QFYVANNKLS CMLTQRSADA FLGVPFNIAS YSLLTHMVAQ 200
    QCNLDVGEFI WSGGDCHIYN NHIEQVNEQL SREPLALPTL KILRKPNSIF 250
    DYKYEDFEFE NYNHHPAIKA KISV 274
    Length:274
    Mass (Da):31,376
    Last modified:January 9, 2007 - v1
    Checksum:i6A1B81E97C240C9A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK90129.1.
    RefSeqiYP_898883.1. NC_008601.1.

    Genome annotation databases

    EnsemblBacteriaiABK90129; ABK90129; FTN_1248.
    GeneIDi4548047.
    KEGGiftn:FTN_1248.
    PATRICi17935647. VBIFraNov128299_1285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK90129.1 .
    RefSeqi YP_898883.1. NC_008601.1.

    3D structure databases

    ProteinModelPortali A0Q7B4.
    SMRi A0Q7B4. Positions 2-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 401614.FTN_1248.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK90129 ; ABK90129 ; FTN_1248 .
    GeneIDi 4548047.
    KEGGi ftn:FTN_1248.
    PATRICi 17935647. VBIFraNov128299_1285.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257899.
    KOi K00560.
    OMAi QCHEAIQ.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci FNOV401614:GC4M-1247-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: U112.

    Entry informationi

    Entry nameiTYSY_FRATN
    AccessioniPrimary (citable) accession number: A0Q7B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3