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Protein

Thymidine kinase

Gene

tdk

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1
Metal bindingi190ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi87 – 90ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:FTN_1060Imported
OrganismiFrancisella tularensis subsp. novicida (strain U112)Imported
Taxonomic identifieri401614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000000762 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiA0Q6T2

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0Q6T2
SMRiA0Q6T2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391
KOiK00857
OMAiKEQFGWI

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

A0Q6T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFRYSA MDAGKTLDLL KVAYNYEDRG RKPLVLTSAI DKRAGLNKVK
60 70 80 90 100
SRIGIDQDAY SLTDRDNIFE FVENYNSSNK IDCVLIDEIH FFTQEQVWQL
110 120 130 140 150
AEIVDELNIP VICYGLRTNY LGQPFETAAL LLAIADTLEE VKTICHCGKK
160 170 180 190
ASFNMMVQNG KAIKQGNPIV VDDDSLKEID TKYVSVCRKH WKEGVYE
Length:197
Mass (Da):22,474
Last modified:January 9, 2007 - v1
Checksum:iB05840573A52BC7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA Translation: ABK89947.1
RefSeqiWP_003018771.1, NZ_CP009633.1

Genome annotation databases

EnsemblBacteriaiABK89947; ABK89947; FTN_1060
KEGGiftn:FTN_1060
ftx:AW25_948

Similar proteinsi

Entry informationi

Entry nameiA0Q6T2_FRATN
AccessioniPrimary (citable) accession number: A0Q6T2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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