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A0Q693

- SYL_FRATN

UniProt

A0Q693 - SYL_FRATN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei578 – 5781ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFNOV401614:GC4M-869-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:FTN_0870
    OrganismiFrancisella tularensis subsp. novicida (strain U112)
    Taxonomic identifieri401614 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000762: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 813813Leucine--tRNA ligasePRO_1000009343Add
    BLAST

    Proteomic databases

    PRIDEiA0Q693.

    Interactioni

    Protein-protein interaction databases

    STRINGi401614.FTN_0870.

    Structurei

    3D structure databases

    ProteinModelPortaliA0Q693.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi575 – 5795"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0Q693-1 [UniParc]FASTAAdd to Basket

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    MNEYNFSDIE KSTQDYWRKN DTFKTIEDNT KEKFYCLSML PYPSGTLHMG    50
    HVRNYTIGDV IARYQKMQGK NVLHPMGWDA FGLPAENAAI KHKKSPYEWT 100
    KSNIAYMRSQ LDSLGFSFDW SREIATCDED YYKWEQWFFI QLYKKGLAYR 150
    KNSVVNWDPV DQTVLANEQV VDGRGWRSGA LVEKKEIPQW FLKITDYADE 200
    LLQDISKLDG WPEAVKTMQI NWIGKSKGLT VKFKIKDSNQ EIEVFTTRPD 250
    TLMGVNYLGI APEHPLALEE AKTNSKLAAF IEECKKTSTM EADLATQEKK 300
    GFKTSIKVIH PISAETIDVW VANFVLMGYG SGAVMSVPAH DQRDWEFAQK 350
    YNIPLKQVIE SNDKKLKIDL EKQAFTEKGI LINSGEFDGL NFKNAYQAIK 400
    KYLTEQNKGY ETTNFRIHDW GISRQRYWGC PIPMIHCDDC GAVPEKEENL 450
    PVRLPTDVTL TEAGSPLKDI PEFINVACPE CGKPAKRETD TFDTFFESSW 500
    YYARYTCPTA NQMLDQEANY WLPVDKYIGG IEHAIMHLLY ARFFHKLMRD 550
    QGLVKSDEPF KNLLTQGMVL KDGAKMSKSK GNTVDPQELI DRYGADTVRL 600
    FSMFAAPPEQ SLEWSETGVE GANKFLRKVF NYAELNKDIF AKNITLESQK 650
    LTKEDKKARF EIHSNLKQAI FDFDKSQFNT VVSACMKILN TLNNYDNLSE 700
    SVKVEGFSIL LRILAPFTPH LCHYLWQQLN LGEDILHTSF PTVDNNALEK 750
    DEFLLVVQIN GKLKAKLELD ASLSPNQVEE IVLADQHVKS FIDNKQVVKV 800
    IYVPQKLINI VIK 813
    Length:813
    Mass (Da):93,397
    Last modified:January 9, 2007 - v1
    Checksum:i5B34B6538A2223E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK89758.1.
    RefSeqiYP_898512.1. NC_008601.1.

    Genome annotation databases

    EnsemblBacteriaiABK89758; ABK89758; FTN_0870.
    GeneIDi4547238.
    KEGGiftn:FTN_0870.
    PATRICi17934858. VBIFraNov128299_0896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK89758.1 .
    RefSeqi YP_898512.1. NC_008601.1.

    3D structure databases

    ProteinModelPortali A0Q693.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 401614.FTN_0870.

    Proteomic databases

    PRIDEi A0Q693.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK89758 ; ABK89758 ; FTN_0870 .
    GeneIDi 4547238.
    KEGGi ftn:FTN_0870.
    PATRICi 17934858. VBIFraNov128299_0896.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci FNOV401614:GC4M-869-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: U112.

    Entry informationi

    Entry nameiSYL_FRATN
    AccessioniPrimary (citable) accession number: A0Q693
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3