ID A0Q5R2_FRATN Unreviewed; 382 AA. AC A0Q5R2; DT 09-JAN-2007, integrated into UniProtKB/TrEMBL. DT 09-JAN-2007, sequence version 1. DT 27-MAR-2024, entry version 112. DE RecName: Full=Galactokinase {ECO:0000256|ARBA:ARBA00012315, ECO:0000256|HAMAP-Rule:MF_00246}; DE EC=2.7.1.6 {ECO:0000256|ARBA:ARBA00012315, ECO:0000256|HAMAP-Rule:MF_00246}; DE AltName: Full=Galactose kinase {ECO:0000256|ARBA:ARBA00029590, ECO:0000256|HAMAP-Rule:MF_00246}; GN Name=galK {ECO:0000256|HAMAP-Rule:MF_00246, GN ECO:0000313|EMBL:ABK89577.1}; GN OrderedLocusNames=FTN_0685 {ECO:0000313|EMBL:ABK89577.1}; GN ORFNames=AW25_1340 {ECO:0000313|EMBL:AJI61186.1}; OS Francisella tularensis subsp. novicida (strain U112). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales; OC Francisellaceae; Francisella. OX NCBI_TaxID=401614 {ECO:0000313|EMBL:ABK89577.1, ECO:0000313|Proteomes:UP000000762}; RN [1] {ECO:0000313|EMBL:ABK89577.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=U112 {ECO:0000313|EMBL:ABK89577.1}; RA Brittnacher M., Rohmer L., Zhou Y., Abmayr S., D'Argenio D., Bovee D., RA Chang J., Chen J., Drees B., Ernst R., Fong C., Forsman M., Gallagher L., RA Gallis B., Gillett W., Goodlett D., Guina T., Guenthner D., Haugen E., RA Hayden H., Jacobs M., Kang A., Larson Freeman T., Levy R., Lim R., RA Manoil C., Olson M.V., Radey M., Shaffer S., Svensson K., Taylor G., RA Wasnick M., Kaul R., Miller S.I.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000000762} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=U112 {ECO:0000313|Proteomes:UP000000762}; RX PubMed=17550600; DOI=10.1186/gb-2007-8-6-r102; RA Rohmer L., Fong C., Abmayr S., Wasnick M., Larson Freeman T.J., Radey M., RA Guina T., Svensson K., Hayden H.S., Jacobs M., Gallagher L.A., Manoil C., RA Ernst R.K., Drees B., Buckley D., Haugen E., Bovee D., Zhou Y., Chang J., RA Levy R., Lim R., Gillett W., Guenthener D., Kang A., Shaffer S.A., RA Taylor G., Chen J., Gallis B., D'Argenio D.A., Forsman M., Olson M.V., RA Goodlett D.R., Kaul R., Miller S.I., Brittnacher M.J.; RT "Comparison of Francisella tularensis genomes reveals evolutionary events RT associated with the emergence of human pathogenic strains."; RL Genome Biol. 8:R102.1-R102.16(2007). RN [3] {ECO:0000313|EMBL:AJI61186.1, ECO:0000313|Proteomes:UP000031872} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=U112 {ECO:0000313|EMBL:AJI61186.1, RC ECO:0000313|Proteomes:UP000031872}; RX PubMed=25931589; RA Johnson S.L., Daligault H.E., Davenport K.W., Coyne S.R., Frey K.G., RA Koroleva G.I., Broomall S.M., Bishop-Lilly K.A., Bruce D.C., Chertkov O., RA Freitas T., Jaissle J., Ladner J.T., Rosenzweig C.N., Gibbons H.S., RA Palacios G.F., Redden C.L., Xu Y., Minogue T.D., Chain P.S.; RT "Genome sequencing of 18 francisella strains to aid in assay development RT and testing."; RL Genome Announc. 3:0-0(2015). CC -!- FUNCTION: Catalyzes the transfer of the gamma-phosphate of ATP to D- CC galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). CC {ECO:0000256|HAMAP-Rule:MF_00246}. CC -!- CATALYTIC ACTIVITY: CC Reaction=alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate CC + H(+); Xref=Rhea:RHEA:13553, ChEBI:CHEBI:15378, ChEBI:CHEBI:28061, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58336, ChEBI:CHEBI:456216; EC=2.7.1.6; CC Evidence={ECO:0000256|HAMAP-Rule:MF_00246}; CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism. CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|HAMAP-Rule:MF_00246}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00246}. CC -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily. CC {ECO:0000256|ARBA:ARBA00006566, ECO:0000256|HAMAP-Rule:MF_00246}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000439; ABK89577.1; -; Genomic_DNA. DR EMBL; CP009633; AJI61186.1; -; Genomic_DNA. DR RefSeq; WP_003038806.1; NZ_CP009633.1. DR AlphaFoldDB; A0Q5R2; -. DR KEGG; ftn:FTN_0685; -. DR KEGG; ftx:AW25_1340; -. DR BioCyc; FTUL401614:G1G75-713-MONOMER; -. DR UniPathway; UPA00214; -. DR Proteomes; UP000000762; Chromosome. DR Proteomes; UP000031872; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004335; F:galactokinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule. DR Gene3D; 3.30.230.10; -; 1. DR Gene3D; 3.30.70.890; GHMP kinase, C-terminal domain; 1. DR HAMAP; MF_00246; Galactokinase; 1. DR InterPro; IPR000705; Galactokinase. DR InterPro; IPR022963; Galactokinase_bac. DR InterPro; IPR019741; Galactokinase_CS. DR InterPro; IPR019539; GalKase_N. DR InterPro; IPR013750; GHMP_kinase_C_dom. DR InterPro; IPR036554; GHMP_kinase_C_sf. DR InterPro; IPR006204; GHMP_kinase_N_dom. DR InterPro; IPR006203; GHMP_knse_ATP-bd_CS. DR InterPro; IPR006206; Mevalonate/galactokinase. DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF. DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr. DR NCBIfam; TIGR00131; gal_kin; 1. DR PANTHER; PTHR10457:SF35; GALACTOKINASE; 1. DR PANTHER; PTHR10457; MEVALONATE KINASE/GALACTOKINASE; 1. DR Pfam; PF10509; GalKase_gal_bdg; 1. DR Pfam; PF08544; GHMP_kinases_C; 1. DR Pfam; PF00288; GHMP_kinases_N; 1. DR PIRSF; PIRSF000530; Galactokinase; 1. DR PRINTS; PR00473; GALCTOKINASE. DR PRINTS; PR00959; MEVGALKINASE. DR SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1. DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1. DR PROSITE; PS00106; GALACTOKINASE; 1. DR PROSITE; PS00627; GHMP_KINASES_ATP; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00246}; KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP- KW Rule:MF_00246}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00246}; KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144, ECO:0000256|HAMAP- KW Rule:MF_00246}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|HAMAP-Rule:MF_00246}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_00246}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP- KW Rule:MF_00246}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00246}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP- KW Rule:MF_00246}. FT DOMAIN 12..59 FT /note="Galactokinase N-terminal" FT /evidence="ECO:0000259|Pfam:PF10509" FT DOMAIN 114..181 FT /note="GHMP kinase N-terminal" FT /evidence="ECO:0000259|Pfam:PF00288" FT DOMAIN 281..345 FT /note="GHMP kinase C-terminal" FT /evidence="ECO:0000259|Pfam:PF08544" FT ACT_SITE 174 FT /note="Proton acceptor" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00246" FT BINDING 35..38 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00246" FT BINDING 69 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00246" FT BINDING 124..130 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00246" FT BINDING 130 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00246" FT BINDING 162 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00246" FT BINDING 224 FT /ligand="substrate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00246" FT SITE 29 FT /note="Transition state stabilizer" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00246" SQ SEQUENCE 382 AA; 43488 MW; C28B34A038EFE785 CRC64; MMDCIKHNLI NRFVELYGRK PQLFFSPGRV NLIGEHTDYN NGFVMPFAIN KGTFIAIAKR DDNIVNVYSE NLDDSSSFDI TKIKQEISNT WQNYIKGVIN IINQNFSSDI KGADIYIFSD LPFGAGLSSS ASLNTALAYA YNDIYQLNIS KIDLAKIAQK VEHEYIGTKC GLMDQMACLF SQQNAATMID CNDNHYDNIP FELDNLSVLI CDTNIKHNLA DSAYNKRRQV CENIARFHSI KSLRELDSQK LEDTKLNFSE EDYKLALHVF TENQRVIEAT KAMVAKDWQK LGKLMYQSHN SLKNDYKVSC DELDYLVELS QNFAGIYGAR MTGGGFGGST IHLLPTKLLK EYTSYLEKNY FQKFNIKPSF YISKACQGTC KL //