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A0Q5R2

- A0Q5R2_FRATN

UniProt

A0Q5R2 - A0Q5R2_FRATN

Protein

Galactokinase

Gene

galK

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei29 – 291Transition state stabilizerUniRule annotation
    Binding sitei69 – 691ATPUniRule annotation
    Metal bindingi130 – 1301MagnesiumUniRule annotation
    Metal bindingi162 – 1621MagnesiumUniRule annotation
    Active sitei174 – 1741Proton acceptorUniRule annotation
    Binding sitei224 – 2241SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi124 – 1307ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. galactokinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. galactose metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Galactose metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFNOV401614:GC4M-684-MONOMER.
    UniPathwayiUPA00214.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GalactokinaseUniRule annotation (EC:2.7.1.6UniRule annotation)
    Alternative name(s):
    Galactose kinaseUniRule annotation
    Gene namesi
    Name:galKUniRule annotationImported
    Ordered Locus Names:FTN_0685Imported
    OrganismiFrancisella tularensis subsp. novicida (strain U112)Imported
    Taxonomic identifieri401614 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000000762: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi401614.FTN_0685.

    Structurei

    3D structure databases

    ProteinModelPortaliA0Q5R2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni35 – 384Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the GHMP kinase family. GalK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0153.
    HOGENOMiHOG000241101.
    KOiK00849.
    OMAiVMPCAIN.
    OrthoDBiEOG6DG2SH.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00246. Galactokinase.
    InterProiIPR000705. Galactokinase.
    IPR022963. Galactokinase_bac.
    IPR019741. Galactokinase_CS.
    IPR019539. GalKase_gal-bd.
    IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006206. Mevalonate/galactokinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PfamiPF10509. GalKase_gal_bdg. 1 hit.
    PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000530. Galactokinase. 1 hit.
    PRINTSiPR00473. GALCTOKINASE.
    PR00959. MEVGALKINASE.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00131. gal_kin. 1 hit.
    PROSITEiPS00106. GALACTOKINASE. 1 hit.
    PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0Q5R2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDCIKHNLI NRFVELYGRK PQLFFSPGRV NLIGEHTDYN NGFVMPFAIN    50
    KGTFIAIAKR DDNIVNVYSE NLDDSSSFDI TKIKQEISNT WQNYIKGVIN 100
    IINQNFSSDI KGADIYIFSD LPFGAGLSSS ASLNTALAYA YNDIYQLNIS 150
    KIDLAKIAQK VEHEYIGTKC GLMDQMACLF SQQNAATMID CNDNHYDNIP 200
    FELDNLSVLI CDTNIKHNLA DSAYNKRRQV CENIARFHSI KSLRELDSQK 250
    LEDTKLNFSE EDYKLALHVF TENQRVIEAT KAMVAKDWQK LGKLMYQSHN 300
    SLKNDYKVSC DELDYLVELS QNFAGIYGAR MTGGGFGGST IHLLPTKLLK 350
    EYTSYLEKNY FQKFNIKPSF YISKACQGTC KL 382
    Length:382
    Mass (Da):43,488
    Last modified:January 9, 2007 - v1
    Checksum:iC28B34A038EFE785
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK89577.1.
    RefSeqiYP_898331.1. NC_008601.1.

    Genome annotation databases

    EnsemblBacteriaiABK89577; ABK89577; FTN_0685.
    GeneIDi4547301.
    KEGGiftn:FTN_0685.
    PATRICi17934472. VBIFraNov128299_0705.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000439 Genomic DNA. Translation: ABK89577.1 .
    RefSeqi YP_898331.1. NC_008601.1.

    3D structure databases

    ProteinModelPortali A0Q5R2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 401614.FTN_0685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK89577 ; ABK89577 ; FTN_0685 .
    GeneIDi 4547301.
    KEGGi ftn:FTN_0685.
    PATRICi 17934472. VBIFraNov128299_0705.

    Phylogenomic databases

    eggNOGi COG0153.
    HOGENOMi HOG000241101.
    KOi K00849.
    OMAi VMPCAIN.
    OrthoDBi EOG6DG2SH.

    Enzyme and pathway databases

    UniPathwayi UPA00214 .
    BioCyci FNOV401614:GC4M-684-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00246. Galactokinase.
    InterProi IPR000705. Galactokinase.
    IPR022963. Galactokinase_bac.
    IPR019741. Galactokinase_CS.
    IPR019539. GalKase_gal-bd.
    IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006206. Mevalonate/galactokinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    Pfami PF10509. GalKase_gal_bdg. 1 hit.
    PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000530. Galactokinase. 1 hit.
    PRINTSi PR00473. GALCTOKINASE.
    PR00959. MEVGALKINASE.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00131. gal_kin. 1 hit.
    PROSITEi PS00106. GALACTOKINASE. 1 hit.
    PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: U112Imported.

    Entry informationi

    Entry nameiA0Q5R2_FRATN
    AccessioniPrimary (citable) accession number: A0Q5R2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3