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Protein

Galactokinase

Gene

galK

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).UniRule annotationSAAS annotation

Catalytic activityi

ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.UniRule annotationSAAS annotation

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei29Transition state stabilizerUniRule annotation1
Binding sitei69ATPUniRule annotation1
Metal bindingi130MagnesiumUniRule annotation1
Metal bindingi162MagnesiumUniRule annotation1
Active sitei174Proton acceptorUniRule annotation1
Binding sitei224SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi124 – 130ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processCarbohydrate metabolism, Galactose metabolismUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFTUL401614:G1G75-713-MONOMER
UniPathwayiUPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
GalactokinaseUniRule annotationSAAS annotation (EC:2.7.1.6UniRule annotationSAAS annotation)
Alternative name(s):
Galactose kinaseUniRule annotation
Gene namesi
Name:galKUniRule annotationImported
Ordered Locus Names:FTN_0685Imported
OrganismiFrancisella tularensis subsp. novicida (strain U112)Imported
Taxonomic identifieri401614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000000762 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiA0Q5R2

Structurei

3D structure databases

ProteinModelPortaliA0Q5R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 58GalKase_gal_bdgInterPro annotationAdd BLAST47
Domaini114 – 181GHMP_kinases_NInterPro annotationAdd BLAST68
Domaini280 – 346GHMP_kinases_CInterPro annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 38Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the GHMP kinase family. GalK subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000241101
KOiK00849
OMAiYECSHPD

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
HAMAPiMF_00246 Galactokinase, 1 hit
InterProiView protein in InterPro
IPR000705 Galactokinase
IPR022963 Galactokinase_bac
IPR019741 Galactokinase_CS
IPR019539 GalKase_gal-bd
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR006206 Mevalonate/galactokinase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10457:SF6 PTHR10457:SF6, 1 hit
PfamiView protein in Pfam
PF10509 GalKase_gal_bdg, 1 hit
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF000530 Galactokinase, 1 hit
PRINTSiPR00473 GALCTOKINASE
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00131 gal_kin, 1 hit
PROSITEiView protein in PROSITE
PS00106 GALACTOKINASE, 1 hit
PS00627 GHMP_KINASES_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

A0Q5R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDCIKHNLI NRFVELYGRK PQLFFSPGRV NLIGEHTDYN NGFVMPFAIN
60 70 80 90 100
KGTFIAIAKR DDNIVNVYSE NLDDSSSFDI TKIKQEISNT WQNYIKGVIN
110 120 130 140 150
IINQNFSSDI KGADIYIFSD LPFGAGLSSS ASLNTALAYA YNDIYQLNIS
160 170 180 190 200
KIDLAKIAQK VEHEYIGTKC GLMDQMACLF SQQNAATMID CNDNHYDNIP
210 220 230 240 250
FELDNLSVLI CDTNIKHNLA DSAYNKRRQV CENIARFHSI KSLRELDSQK
260 270 280 290 300
LEDTKLNFSE EDYKLALHVF TENQRVIEAT KAMVAKDWQK LGKLMYQSHN
310 320 330 340 350
SLKNDYKVSC DELDYLVELS QNFAGIYGAR MTGGGFGGST IHLLPTKLLK
360 370 380
EYTSYLEKNY FQKFNIKPSF YISKACQGTC KL
Length:382
Mass (Da):43,488
Last modified:January 9, 2007 - v1
Checksum:iC28B34A038EFE785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA Translation: ABK89577.1
RefSeqiWP_003038806.1, NZ_CP009633.1

Genome annotation databases

EnsemblBacteriaiABK89577; ABK89577; FTN_0685
KEGGiftn:FTN_0685
ftx:AW25_1340

Similar proteinsi

Entry informationi

Entry nameiA0Q5R2_FRATN
AccessioniPrimary (citable) accession number: A0Q5R2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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