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Protein

Galactokinase

Gene

galK

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).UniRule annotationSAAS annotation

Catalytic activityi

ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.UniRule annotationSAAS annotation

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei29Transition state stabilizerUniRule annotation1
Binding sitei69ATPUniRule annotation1
Metal bindingi130MagnesiumUniRule annotation1
Metal bindingi162MagnesiumUniRule annotation1
Active sitei174Proton acceptorUniRule annotation1
Binding sitei224SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi124 – 130ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationImported, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
GalactokinaseUniRule annotationSAAS annotation (EC:2.7.1.6UniRule annotationSAAS annotation)
Alternative name(s):
Galactose kinaseUniRule annotation
Gene namesi
Name:galKUniRule annotationImported
Ordered Locus Names:FTN_0685Imported
OrganismiFrancisella tularensis subsp. novicida (strain U112)Imported
Taxonomic identifieri401614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000000762 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0Q5R2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 58GalKase_gal_bdgInterPro annotationAdd BLAST47
Domaini114 – 181GHMP_kinases_NInterPro annotationAdd BLAST68
Domaini280 – 346GHMP_kinases_CInterPro annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 38Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the GHMP kinase family. GalK subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000241101.
KOiK00849.
OMAiVMPCAIN.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00246. Galactokinase. 1 hit.
InterProiIPR000705. Galactokinase.
IPR022963. Galactokinase_bac.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PTHR10457:SF6. PTHR10457:SF6. 1 hit.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00131. gal_kin. 1 hit.
PROSITEiPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q5R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDCIKHNLI NRFVELYGRK PQLFFSPGRV NLIGEHTDYN NGFVMPFAIN
60 70 80 90 100
KGTFIAIAKR DDNIVNVYSE NLDDSSSFDI TKIKQEISNT WQNYIKGVIN
110 120 130 140 150
IINQNFSSDI KGADIYIFSD LPFGAGLSSS ASLNTALAYA YNDIYQLNIS
160 170 180 190 200
KIDLAKIAQK VEHEYIGTKC GLMDQMACLF SQQNAATMID CNDNHYDNIP
210 220 230 240 250
FELDNLSVLI CDTNIKHNLA DSAYNKRRQV CENIARFHSI KSLRELDSQK
260 270 280 290 300
LEDTKLNFSE EDYKLALHVF TENQRVIEAT KAMVAKDWQK LGKLMYQSHN
310 320 330 340 350
SLKNDYKVSC DELDYLVELS QNFAGIYGAR MTGGGFGGST IHLLPTKLLK
360 370 380
EYTSYLEKNY FQKFNIKPSF YISKACQGTC KL
Length:382
Mass (Da):43,488
Last modified:January 9, 2007 - v1
Checksum:iC28B34A038EFE785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA. Translation: ABK89577.1.
RefSeqiWP_003038806.1. NZ_CP009633.1.

Genome annotation databases

EnsemblBacteriaiABK89577; ABK89577; FTN_0685.
KEGGiftn:FTN_0685.
ftx:AW25_1340.
PATRICi17934472. VBIFraNov128299_0705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA. Translation: ABK89577.1.
RefSeqiWP_003038806.1. NZ_CP009633.1.

3D structure databases

ProteinModelPortaliA0Q5R2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK89577; ABK89577; FTN_0685.
KEGGiftn:FTN_0685.
ftx:AW25_1340.
PATRICi17934472. VBIFraNov128299_0705.

Phylogenomic databases

HOGENOMiHOG000241101.
KOiK00849.
OMAiVMPCAIN.

Enzyme and pathway databases

UniPathwayiUPA00214.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00246. Galactokinase. 1 hit.
InterProiIPR000705. Galactokinase.
IPR022963. Galactokinase_bac.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 1 hit.
PTHR10457:SF6. PTHR10457:SF6. 1 hit.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00131. gal_kin. 1 hit.
PROSITEiPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA0Q5R2_FRATN
AccessioniPrimary (citable) accession number: A0Q5R2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.