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A0Q5R2 (A0Q5R2_FRATN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Galactokinase HAMAP-Rule MF_00246

EC=2.7.1.6 HAMAP-Rule MF_00246
Alternative name(s):
Galactose kinase HAMAP-Rule MF_00246
Gene names
Name:galK HAMAP-Rule MF_00246 EMBL ABK89577.1
Ordered Locus Names:FTN_0685 EMBL ABK89577.1
OrganismFrancisella tularensis subsp. novicida (strain U112) [Complete proteome] [HAMAP] EMBL ABK89577.1
Taxonomic identifier401614 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) By similarity. HAMAP-Rule MF_00246 SAAS SAAS006203

Catalytic activity

ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP-Rule MF_00246 SAAS SAAS006203

Pathway

Carbohydrate metabolism; galactose metabolism. HAMAP-Rule MF_00246 SAAS SAAS006203

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00246 SAAS SAAS006203.

Sequence similarities

Belongs to the GHMP kinase family. GalK subfamily. HAMAP-Rule MF_00246

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding124 – 1307ATP By similarity HAMAP-Rule MF_00246
Region35 – 384Substrate binding By similarity HAMAP-Rule MF_00246

Sites

Active site1741Proton acceptor By similarity HAMAP-Rule MF_00246
Metal binding1301Magnesium By similarity HAMAP-Rule MF_00246
Metal binding1621Magnesium By similarity HAMAP-Rule MF_00246
Binding site691ATP By similarity HAMAP-Rule MF_00246
Binding site2241Substrate By similarity HAMAP-Rule MF_00246
Site291Transition state stabilizer By similarity HAMAP-Rule MF_00246

Sequences

Sequence LengthMass (Da)Tools
A0Q5R2 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: C28B34A038EFE785

FASTA38243,488
        10         20         30         40         50         60 
MMDCIKHNLI NRFVELYGRK PQLFFSPGRV NLIGEHTDYN NGFVMPFAIN KGTFIAIAKR 

        70         80         90        100        110        120 
DDNIVNVYSE NLDDSSSFDI TKIKQEISNT WQNYIKGVIN IINQNFSSDI KGADIYIFSD 

       130        140        150        160        170        180 
LPFGAGLSSS ASLNTALAYA YNDIYQLNIS KIDLAKIAQK VEHEYIGTKC GLMDQMACLF 

       190        200        210        220        230        240 
SQQNAATMID CNDNHYDNIP FELDNLSVLI CDTNIKHNLA DSAYNKRRQV CENIARFHSI 

       250        260        270        280        290        300 
KSLRELDSQK LEDTKLNFSE EDYKLALHVF TENQRVIEAT KAMVAKDWQK LGKLMYQSHN 

       310        320        330        340        350        360 
SLKNDYKVSC DELDYLVELS QNFAGIYGAR MTGGGFGGST IHLLPTKLLK EYTSYLEKNY 

       370        380 
FQKFNIKPSF YISKACQGTC KL 

« Hide

References

[1]"Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains."
Rohmer L., Fong C., Abmayr S., Wasnick M., Larson Freeman T.J., Radey M., Guina T., Svensson K., Hayden H.S., Jacobs M., Gallagher L.A., Manoil C., Ernst R.K., Drees B., Buckley D., Haugen E., Bovee D., Zhou Y. expand/collapse author list , Chang J., Levy R., Lim R., Gillett W., Guenthener D., Kang A., Shaffer S.A., Taylor G., Chen J., Gallis B., D'Argenio D.A., Forsman M., Olson M.V., Goodlett D.R., Kaul R., Miller S.I., Brittnacher M.J.
Genome Biol. 8:R102.1-R102.16(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: U112.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000439 Genomic DNA. Translation: ABK89577.1.
RefSeqYP_898331.1. NC_008601.1.

3D structure databases

ProteinModelPortalA0Q5R2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING401614.FTN_0685.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK89577; ABK89577; FTN_0685.
GeneID4547301.
KEGGftn:FTN_0685.
PATRIC17934472. VBIFraNov128299_0705.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0153.
HOGENOMHOG000241101.
KOK00849.
OMAYNDGFVM.
OrthoDBEOG6DG2SH.
ProtClustDBCLSK986378.

Enzyme and pathway databases

BioCycFNOV401614:GC4M-684-MONOMER.
UniPathwayUPA00214.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPMF_00246. Galactokinase.
InterProIPR000705. Galactokinase.
IPR022963. Galactokinase_bac.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000530. Galactokinase. 1 hit.
PRINTSPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsTIGR00131. gal_kin. 1 hit.
PROSITEPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0Q5R2_FRATN
AccessionPrimary (citable) accession number: A0Q5R2
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)