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A0Q588

- GCSPB_FRATN

UniProt

A0Q588 - GCSPB_FRATN

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, FTN_0508
Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciFNOV401614:GC4M-507-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:FTN_0508
OrganismiFrancisella tularensis subsp. novicida (strain U112)
Taxonomic identifieri401614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000762: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000045691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei263 – 2631N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi401614.FTN_0508.

Structurei

3D structure databases

ProteinModelPortaliA0Q588.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiKPVMHEF.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A0Q588-1 [UniParc]FASTAAdd to Basket

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MVIFEKTRGK NSPSVMPSKK GDVSNIPTDM LRTKKPILPE QAELDVVRHY    50
TQLSRKNFCI DTNFYPLGSC TMKYNPRAAH KYASLAGFLE RHPYASAQSI 100
QGTLECLYDL QNLIKELTGM TGVSLAPMAG AQGEFAGVAM IKAYHHKRGD 150
FERDEIIVPD AAHGTNPATA KVCGLKVIEI PTKKDGDIDI EALDKVLGPK 200
TAGIMLTNPS TVGVFERNIA VIAKKVHEAG GLLYYDGANL NAIMGKARPG 250
DMGFDVLHMN LHKTFATPHG GGGPGAGPVA VNDKLKEFLP VPMVGKKDDK 300
FVWLEEKDVP NTIGRLSAFN GNIGVLIRAY IYGAMLGGNG LTEASEIATL 350
NANYMMARLK EEGFTIAYPD RRASHEFIVT LKPEFLNYGV TATDFAKCLI 400
DRGVHAPTMY FPLLVPECLL IEPTETENVD SMEKFIQAMV EIRDIAKKDP 450
QYLKGAPYNL PARRLDDVKA AKELDIVWQP K 481
Length:481
Mass (Da):52,784
Last modified:January 9, 2007 - v1
Checksum:i2DCC172985A360C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000439 Genomic DNA. Translation: ABK89403.1.
RefSeqiYP_898157.1. NC_008601.1.

Genome annotation databases

EnsemblBacteriaiABK89403; ABK89403; FTN_0508.
GeneIDi4547675.
KEGGiftn:FTN_0508.
PATRICi17934107. VBIFraNov128299_0525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000439 Genomic DNA. Translation: ABK89403.1 .
RefSeqi YP_898157.1. NC_008601.1.

3D structure databases

ProteinModelPortali A0Q588.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 401614.FTN_0508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK89403 ; ABK89403 ; FTN_0508 .
GeneIDi 4547675.
KEGGi ftn:FTN_0508.
PATRICi 17934107. VBIFraNov128299_0525.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi KPVMHEF.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci FNOV401614:GC4M-507-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: U112.

Entry informationi

Entry nameiGCSPB_FRATN
AccessioniPrimary (citable) accession number: A0Q588
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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