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A0Q587

- GCSPA_FRATN

UniProt

A0Q587 - GCSPA_FRATN

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciFNOV401614:GC4M-506-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:FTN_0507
OrganismiFrancisella tularensis subsp. novicida (strain U112)
Taxonomic identifieri401614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000762: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045652Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi401614.FTN_0507.

Structurei

3D structure databases

ProteinModelPortaliA0Q587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiFFHEAVL.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A0Q587-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFIPHKLEQ IKKMLDTIGA SSVDQLFDEI PRHLRADTLK IKDGINEIQL
60 70 80 90 100
ANLMRKRANK NHHNTNFIGA GAYSHHIPAA IWDIVARGEF YTAYTPYQAE
110 120 130 140 150
ASQGGLQVIY EFQTMMAGLT GMDASNASMY DGATALAESV LMAIRSNKKA
160 170 180 190 200
KSQKVLIAEA LHPTYLRVLE TITKHQGIEF DIINLDSKNG KTDVTKLEDF
210 220 230 240 250
ANTDYAAVVI QSPNFLGQLA DVDGITNWAH KHGALVIAVT NPMSLAILKS
260 270 280 290 300
PAEWGDNGAD IVCGEGQPMG VPLASGGPYF GFMTCKMAHV RQMPGRIVGR
310 320 330 340 350
TVDLDGNEGF CLTLQAREQH IRRAKATSNI CTNQGLMVTA ATIYMSLLGA
360 370 380 390 400
EGLERVASIS HENTQTLATE LAKINGVSIR FNSAFFNEVV IDLPINAETF
410 420 430 440 450
VTEMEKEGID AGYFLGEYHS DLANSIMVCA TEIHTSEDIK EYIEATKKVL

ARIGG
Length:455
Mass (Da):49,686
Last modified:January 9, 2007 - v1
Checksum:i885860504CFE747B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000439 Genomic DNA. Translation: ABK89402.1.
RefSeqiYP_898156.1. NC_008601.1.

Genome annotation databases

EnsemblBacteriaiABK89402; ABK89402; FTN_0507.
GeneIDi4547674.
KEGGiftn:FTN_0507.
PATRICi17934105. VBIFraNov128299_0524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000439 Genomic DNA. Translation: ABK89402.1 .
RefSeqi YP_898156.1. NC_008601.1.

3D structure databases

ProteinModelPortali A0Q587.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 401614.FTN_0507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK89402 ; ABK89402 ; FTN_0507 .
GeneIDi 4547674.
KEGGi ftn:FTN_0507.
PATRICi 17934105. VBIFraNov128299_0524.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi FFHEAVL.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci FNOV401614:GC4M-506-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: U112.

Entry informationi

Entry nameiGCSPA_FRATN
AccessioniPrimary (citable) accession number: A0Q587
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3