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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381GTPUniRule annotation
Binding sitei142 – 1421GTPUniRule annotation
Binding sitei186 – 1861GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 255GTPUniRule annotation
Nucleotide bindingi107 – 1093GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFNOV401614:GC4M-164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotationImported
Ordered Locus Names:FTN_0164Imported
OrganismiFrancisella tularensis subsp. novicida (strain U112)Imported
Taxonomic identifieri401614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000000762 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0Q4A9.
SMRiA0Q4A9. Positions 2-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 204192TubulinInterPro annotationAdd
BLAST
Domaini206 – 324119Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049094.
KOiK03531.
OMAiAQVIWGI.
OrthoDBiEOG6S7XZG.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q4A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDFNDSMVS NAIIKVVGVG GGGGNAVQHM CEEVSDVEFF ALNTDGQALS
60 70 80 90 100
KSKVQNILQI GTNLTKGLGA GANPEIGKRA ATEDRAKIEQ LLEGADMVFI
110 120 130 140 150
TAGMGGGTGT GGAPVVAEVA KEMGILTVAV VTKPFPFEGP RRMKAAEQGI
160 170 180 190 200
DELTKHVDSI ITVPNEKLLS VLGKGASLID AFNAANDVLG NAVKGVSELI
210 220 230 240 250
TKPGLINVDF ADVRAVMTNM GLAMMGMGEA SGENRAREAA EAAISSPLLE
260 270 280 290 300
DINLDGAKGV IVNITAGMDM SIGEFEEVGE VIRSFISDEA IVIAGTVIDP
310 320 330 340 350
DMSDSMKVTV VVTGIEKVAM KRGFGVEKTS SPQQSASSFS NKTSAPFLRK
360 370 380
ETEVVTGASN APKTDSDDVN KSDIPSFLRR R
Length:381
Mass (Da):39,729
Last modified:January 9, 2007 - v1
Checksum:i48018F5005941430
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA. Translation: ABK89074.1.
RefSeqiWP_011733582.1. NZ_CP009633.1.

Genome annotation databases

EnsemblBacteriaiABK89074; ABK89074; FTN_0164.
KEGGiftn:FTN_0164.
ftx:AW25_36.
PATRICi17933371. VBIFraNov128299_0168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA. Translation: ABK89074.1.
RefSeqiWP_011733582.1. NZ_CP009633.1.

3D structure databases

ProteinModelPortaliA0Q4A9.
SMRiA0Q4A9. Positions 2-315.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK89074; ABK89074; FTN_0164.
KEGGiftn:FTN_0164.
ftx:AW25_36.
PATRICi17933371. VBIFraNov128299_0168.

Phylogenomic databases

HOGENOMiHOG000049094.
KOiK03531.
OMAiAQVIWGI.
OrthoDBiEOG6S7XZG.

Enzyme and pathway databases

BioCyciFNOV401614:GC4M-164-MONOMER.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: U112Imported.

Entry informationi

Entry nameiA0Q4A9_FRATN
AccessioniPrimary (citable) accession number: A0Q4A9
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 6, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.