UniProtKB - A0Q3W9 (TPMT_FRATN)
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Protein
Thiopurine S-methyltransferase
Gene
tpm
Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Functioni
Catalytic activityi
S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 16 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 51 | S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 72 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 131 | S-adenosyl-L-methionineUniRule annotation | 1 |
GO - Molecular functioni
- thiopurine S-methyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- response to metal ion Source: InterPro
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BioCyci | FTUL401614:G1G75-24-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Thiopurine S-methyltransferaseUniRule annotation (EC:2.1.1.67UniRule annotation)Alternative name(s): Thiopurine methyltransferaseUniRule annotation |
Gene namesi | Name:tpmUniRule annotation Ordered Locus Names:FTN_0023 |
Organismi | Francisella tularensis subsp. novicida (strain U112) |
Taxonomic identifieri | 401614 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000047204 | 1 – 226 | Thiopurine S-methyltransferaseAdd BLAST | 226 |
Structurei
3D structure databases
ProteinModelPortali | A0Q3W9. |
SMRi | A0Q3W9. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000262390. |
KOi | K00569. |
OMAi | MKWFADR. |
Family and domain databases
HAMAPi | MF_00812. Thiopur_methtran. 1 hit. |
InterProi | View protein in InterPro IPR029063. SAM-dependent_MTases. IPR022474. Thiopur_S-MeTfrase_Se/Te_detox. IPR025835. Thiopurine_S-MeTrfase. IPR008854. TPMT. |
PANTHERi | PTHR10259. PTHR10259. 1 hit. PTHR10259:SF16. PTHR10259:SF16. 1 hit. |
Pfami | View protein in Pfam PF05724. TPMT. 1 hit. |
PIRSFi | PIRSF023956. Thiopurine_S-methyltransferase. 1 hit. |
SUPFAMi | SSF53335. SSF53335. 1 hit. |
PROSITEi | View protein in PROSITE PS51585. SAM_MT_TPMT. 1 hit. |
i Sequence
Sequence statusi: Complete.
A0Q3W9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKLETNNNQ YWLDRWQNDD VGFCQESPNE FLVKHFSKLN INDSSVCLIP
60 70 80 90 100
MCGCSIDMLF FLSKGVKVVG IELSEKAVLS FFSQNSINYE VIHGNDYKLY
110 120 130 140 150
KGDDIEIYVA DIFNLPKIAN NLPAFDIWYD RGAYIALPND LRTNYAKMML
160 170 180 190 200
EVCPNNTQIL LLVMEHDKKS QTPPYSVTQA ELIKNFSAKI KFELIDSKQR
210 220
DNIPDYRKAE GMTKQYYTTY LRKKQY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000439 Genomic DNA. Translation: ABK88934.1. |
RefSeqi | WP_003040820.1. NZ_CP009633.1. |
Genome annotation databases
EnsemblBacteriai | ABK88934; ABK88934; FTN_0023. |
KEGGi | ftn:FTN_0023. ftx:AW25_179. |
Similar proteinsi
Entry informationi
Entry namei | TPMT_FRATN | |
Accessioni | A0Q3W9Primary (citable) accession number: A0Q3W9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 28, 2018 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |