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Protein

Thiopurine S-methyltransferase

Gene

tpm

Organism
Francisella tularensis subsp. novicida (strain U112)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16S-adenosyl-L-methionineUniRule annotation1
Binding sitei51S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei72S-adenosyl-L-methionineUniRule annotation1
Binding sitei131S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciFTUL401614:G1G75-24-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thiopurine S-methyltransferaseUniRule annotation (EC:2.1.1.67UniRule annotation)
Alternative name(s):
Thiopurine methyltransferaseUniRule annotation
Gene namesi
Name:tpmUniRule annotation
Ordered Locus Names:FTN_0023
OrganismiFrancisella tularensis subsp. novicida (strain U112)
Taxonomic identifieri401614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000000762 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000472041 – 226Thiopurine S-methyltransferaseAdd BLAST226

Proteomic databases

PRIDEiA0Q3W9

Structurei

3D structure databases

ProteinModelPortaliA0Q3W9
SMRiA0Q3W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262390
KOiK00569
OMAiMKWFADR

Family and domain databases

HAMAPiMF_00812 Thiopur_methtran, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR022474 Thiopur_S-MeTfrase_Se/Te_detox
IPR025835 Thiopurine_S-MeTrfase
IPR008854 TPMT
PANTHERiPTHR10259 PTHR10259, 1 hit
PTHR10259:SF16 PTHR10259:SF16, 1 hit
PfamiView protein in Pfam
PF05724 TPMT, 1 hit
PIRSFiPIRSF023956 Thiopurine_S-methyltransferase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51585 SAM_MT_TPMT, 1 hit

Sequencei

Sequence statusi: Complete.

A0Q3W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLETNNNQ YWLDRWQNDD VGFCQESPNE FLVKHFSKLN INDSSVCLIP
60 70 80 90 100
MCGCSIDMLF FLSKGVKVVG IELSEKAVLS FFSQNSINYE VIHGNDYKLY
110 120 130 140 150
KGDDIEIYVA DIFNLPKIAN NLPAFDIWYD RGAYIALPND LRTNYAKMML
160 170 180 190 200
EVCPNNTQIL LLVMEHDKKS QTPPYSVTQA ELIKNFSAKI KFELIDSKQR
210 220
DNIPDYRKAE GMTKQYYTTY LRKKQY
Length:226
Mass (Da):26,339
Last modified:January 9, 2007 - v1
Checksum:i345A2DE8E4F103E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000439 Genomic DNA Translation: ABK88934.1
RefSeqiWP_003040820.1, NZ_CP009633.1

Genome annotation databases

EnsemblBacteriaiABK88934; ABK88934; FTN_0023
KEGGiftn:FTN_0023
ftx:AW25_179

Similar proteinsi

Entry informationi

Entry nameiTPMT_FRATN
AccessioniPrimary (citable) accession number: A0Q3W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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