tpm

Functionⁱ

Catalytic activityⁱ

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	16	S-adenosyl-L-methionineUniRule annotation	1
Binding siteⁱ	51	S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation	1
Binding siteⁱ	72	S-adenosyl-L-methionineUniRule annotation	1
Binding siteⁱ	131	S-adenosyl-L-methionineUniRule annotation	1

GO - Molecular functionⁱ

thiopurine S-methyltransferase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

response to metal ion Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Methyltransferase, Transferase
Ligand	S-adenosyl-L-methionine

Enzyme and pathway databases

BioCycⁱ	FTUL401614:G1G75-24-MONOMER.

BioCycⁱ

FTUL401614:G1G75-24-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thiopurine S-methyltransferaseUniRule annotation (EC:2.1.1.67UniRule annotation) Alternative name(s): Thiopurine methyltransferaseUniRule annotation
Gene namesⁱ	Name:tpmUniRule annotation Ordered Locus Names:FTN_0023
Organismⁱ	Francisella tularensis subsp. novicida (strain U112)
Taxonomic identifierⁱ	401614 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › Francisella tularensis › Francisella novicida
Proteomesⁱ	UP000000762 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00812

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000047204	1 – 226	Thiopurine S-methyltransferaseAdd BLAST		226

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0Q3W9.
SMRⁱ	A0Q3W9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000262390.
KEGG Orthology (KO) More...KOⁱ	K00569.
OMAⁱ	MKWFADR.

Family and domain databases

HAMAPⁱ	MF_00812. Thiopur_methtran. 1 hit.
InterProⁱ	View protein in InterPro IPR029063. SAM-dependent_MTases. IPR022474. Thiopur_S-MeTfrase_Se/Te_detox. IPR025835. Thiopurine_S-MeTrfase. IPR008854. TPMT.
PANTHERⁱ	PTHR10259. PTHR10259. 1 hit. PTHR10259:SF16. PTHR10259:SF16. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05724. TPMT. 1 hit.
PIRSFⁱ	PIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
SUPFAMⁱ	SSF53335. SSF53335. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51585. SAM_MT_TPMT. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0Q3W9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNKLETNNNQ YWLDRWQNDD VGFCQESPNE FLVKHFSKLN INDSSVCLIP 
        60         70         80         90        100
MCGCSIDMLF FLSKGVKVVG IELSEKAVLS FFSQNSINYE VIHGNDYKLY 
       110        120        130        140        150
KGDDIEIYVA DIFNLPKIAN NLPAFDIWYD RGAYIALPND LRTNYAKMML 
       160        170        180        190        200
EVCPNNTQIL LLVMEHDKKS QTPPYSVTQA ELIKNFSAKI KFELIDSKQR 
       210        220 
DNIPDYRKAE GMTKQYYTTY LRKKQY

Length:226

Mass (Da):26,339

Last modified:January 9, 2007 - v1

Checksum:ⁱ345A2DE8E4F103E3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000439 Genomic DNA. Translation: ABK88934.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_003040820.1. NZ_CP009633.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABK88934; ABK88934; FTN_0023.
KEGGⁱ	ftn:FTN_0023. ftx:AW25_179.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0Q3W9	Q14FX6 Q5NEH3 A0A0E2ZQH0 A0A0M1U4B8 A0A0B3VPT0 A0A0B6KMJ3 A0A1S2WUS7 UPI000173E3A6 UPI0001855544 UPI0008FD66A5 +2	Francisella tularensis subsp. tularensis (strain FSC 198) Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) Francisella tularensis Francisella tularensis subsp. holarctica Francisella novicida Francisella sp. TX076608	226	UniRef90_A0Q3W9	Cluster: Thiopurine S-methyltransferase	13

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A0Q3W9	UPI0001855544 A0A0B6KMJ3 Q14FX6 Q5NEH3 A0A0E2ZQH0 A0A0M1U4B8 A0A1S2WUS7 A0A0B3VPT0 UPI000173E3A6 UPI0008FD66A5 +14	Francisella tularensis Francisella novicida Francisella tularensis subsp. tularensis (strain FSC 198) Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) Francisella sp. TX076608 Francisella tularensis subsp. holarctica Francisella hispaniensis FSC454 Francisella cf. novicida (strain 3523) Francisella philomiragia Francisella philomiragia subsp. philomiragia (strain ATCC 25017) And more	226	UniRef50_A0Q3W9	Cluster: Thiopurine S-methyltransferase	25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000439 Genomic DNA. Translation: ABK88934.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_003040820.1. NZ_CP009633.1.

3D structure databases

ProteinModelPortalⁱ	A0Q3W9.
SMRⁱ	A0Q3W9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABK88934; ABK88934; FTN_0023.
KEGGⁱ	ftn:FTN_0023. ftx:AW25_179.

Phylogenomic databases

HOGENOMⁱ	HOG000262390.
KEGG Orthology (KO) More...KOⁱ	K00569.
OMAⁱ	MKWFADR.

Enzyme and pathway databases

BioCycⁱ	FTUL401614:G1G75-24-MONOMER.

BioCycⁱ

FTUL401614:G1G75-24-MONOMER.

Family and domain databases

HAMAPⁱ	MF_00812. Thiopur_methtran. 1 hit.
InterProⁱ	View protein in InterPro IPR029063. SAM-dependent_MTases. IPR022474. Thiopur_S-MeTfrase_Se/Te_detox. IPR025835. Thiopurine_S-MeTrfase. IPR008854. TPMT.
PANTHERⁱ	PTHR10259. PTHR10259. 1 hit. PTHR10259:SF16. PTHR10259:SF16. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05724. TPMT. 1 hit.
PIRSFⁱ	PIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
SUPFAMⁱ	SSF53335. SSF53335. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51585. SAM_MT_TPMT. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPMT_FRATN
Accessionⁱ	A0Q3W9Primary (citable) accession number: A0Q3W9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	January 9, 2007
	Last modified:	February 28, 2018
	This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB - A0Q3W9 (TPMT_FRATN)

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Thiopurine S-methyltransferase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0Q3W9 (TPMT_FRATN)

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Thiopurine S-methyltransferase

tpm

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ