Reviewed, UniProtKB/Swiss-Prot A0Q380 (COMB_CLONN)

Names and origin

Protein names

Recommended name:
    Probable 2-phosphosulfolactate phosphatase
    EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	NT01CX_0616

Organism

Clostridium novyi (strain NT) [Complete proteome] [HAMAP]

Taxonomic identifier

386415 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the comB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 235	235	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000014462

Sequences

	Sequence		Length	Mass (Da)
	A0Q380-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: AAB79203DB32262E	FASTA	235	26,135
	10 20 30 40 50 60 MKIDLIISAS DIKEEKIKNK TVVVIDILRA TSVIVTALNN GCNEVIPVLE VEDAMKIVKD 70 80 90 100 110 120 NRKKYILGGE RNALKIEGFD FSNSPLDYTK DVVKDKTLVM TTTNGTRAIH GAMSAKNILI 130 140 150 160 170 180 GAMINARSIA NKVLELDNDL IIINSGTNGE FSIDDFVCAG YIIDCILKNR DAELSDIAIT 190 200 210 220 230 AHYVYSENKD IHSFVHKAKH YNILSNLGLK DDINYCCSKD IVDIVPEFHY PKITK

References

[1]

"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT." Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S. Nat. Biotechnol. 24:1573-1580(2006) [PubMed: 17115055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000382 Genomic DNA. Translation: ABK60442.1.
RefSeq	YP_879082.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4540670.
GenomeReviews	Gene locus NT01CX_0616 in contig CP000382_GR.
KEGG	cno:NT01CX_0616.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A0Q380. DFICSGY.
Family and domain databases
HAMAP	MF_00490. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COMB_CLONN

Accession

Primary (citable) accession number: A0Q380

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	May 5, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)