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A0Q315 (A0Q315_CLONN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase HAMAP-Rule MF_00124 RuleBase RU000544

EC=2.7.1.21 HAMAP-Rule MF_00124 RuleBase RU000544
Gene names
Name:tdk HAMAP-Rule MF_00124
Ordered Locus Names:NT01CX_0551 EMBL ABK61339.1
OrganismClostridium novyi (strain NT) [Complete proteome] [HAMAP] EMBL ABK61339.1
Taxonomic identifier386415 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124 RuleBase RU000544 SAAS SAAS020634

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family. HAMAP-Rule MF_00124

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding9 – 168ATP By similarity HAMAP-Rule MF_00124
Nucleotide binding88 – 914ATP By similarity HAMAP-Rule MF_00124

Sites

Active site891Proton acceptor By similarity HAMAP-Rule MF_00124
Metal binding1461Zinc By similarity HAMAP-Rule MF_00124
Metal binding1481Zinc By similarity HAMAP-Rule MF_00124
Metal binding1841Zinc By similarity HAMAP-Rule MF_00124
Metal binding1871Zinc By similarity HAMAP-Rule MF_00124

Sequences

Sequence LengthMass (Da)Tools
A0Q315 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 50839D3F8C0DA57C

FASTA19822,757
        10         20         30         40         50         60 
MSKLYFRYGA MNSGKSTNLM QVAHNYEERG MKVIIIKPKT DSKGGENVVS RLGVTRRVDM 

        70         80         90        100        110        120 
LLESNENAYE KVKDICNKEG KVNCVLVDEV QFFKKDQIDQ LLEIAVKLDI PTICYGLRTD 

       130        140        150        160        170        180 
FQMNGFEGST RLLLLAHSIE ELKTICRCGR KALLNGRKIN GKFVFEGKQV AIDKEDNVEY 

       190 
ESLCPKCYFE FRDKYNNK 

« Hide

References

[1]"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT."
Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A.Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S.
Nat. Biotechnol. 24:1573-1580(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NT EMBL ABK61339.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000382 Genomic DNA. Translation: ABK61339.1.
RefSeqYP_879017.1. NC_008593.1.

3D structure databases

ProteinModelPortalA0Q315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING386415.NT01CX_0551.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK61339; ABK61339; NT01CX_0551.
GeneID4540181.
KEGGcno:NT01CX_0551.
PATRIC19481656. VBICloNov112828_2055.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076391.
KOK00857.
OMAELKTVCH.
OrthoDBEOG69D3J2.

Enzyme and pathway databases

BioCycCNOV386415:GH98-2115-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0Q315_CLONN
AccessionPrimary (citable) accession number: A0Q315
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)