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A0Q2X7 (SECA_CLONN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein translocase subunit SecA
Gene names
Name:secA
Ordered Locus Names:NT01CX_0509
OrganismClostridium novyi (strain NT) [Complete proteome] [HAMAP]
Taxonomic identifier386415 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length834 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity. HAMAP-Rule MF_01382

Cofactor

May bind 1 zinc ion per subunit Potential.

Subunit structure

Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved By similarity. HAMAP-Rule MF_01382

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: Distribution is 50-50 By similarity. HAMAP-Rule MF_01382

Sequence similarities

Belongs to the SecA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 834834Protein translocase subunit SecA HAMAP-Rule MF_01382
PRO_0000320781

Regions

Nucleotide binding100 – 1078ATP Potential

Sites

Metal binding8201Zinc Potential
Metal binding8221Zinc Potential
Metal binding8311Zinc Potential
Metal binding8321Zinc Potential

Sequences

Sequence LengthMass (Da)Tools
A0Q2X7 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 0F58ACF6A12C0CE9

FASTA83495,455
        10         20         30         40         50         60 
MGLFEKIFGT YSSREIKKII PIINKIDSYE EEFKKLTDEE LRNKTDEFKD MLAKGKTLDD 

        70         80         90        100        110        120 
ILPEAFAVAR EASARVLGMR HFREQLIGGI VLHQGRISEM KTGEGKTLVA TLPAYLNALS 

       130        140        150        160        170        180 
GKGVHVITVN DYLAKRDRDQ MSQLYGFLGL TTGVIVHDLD NEQRREAYNC DITYGTNNEF 

       190        200        210        220        230        240 
GFDYLRDNMV IYKEERVQRK LNFCIVDEVD SILIDEARTP LIISGEGDNS TDFYKVADFF 

       250        260        270        280        290        300 
AKTLKEDDYT VDEKTNSVIL TEQGIEKAEK FFHIDNYGDG DNMQIQHHVV QALKANYTMK 

       310        320        330        340        350        360 
RDKDYMVKDN EVIIVDEFTG RLMEGRRYSD GLHQAIEAKE NVKIQKESKT LATITFQNYF 

       370        380        390        400        410        420 
RMYTKLSGMT GTAQTEEAEF REIYGLDVIV IPTHRPIARI DAPDVVYKSE KAKFKAIVNE 

       430        440        450        460        470        480 
IAETYKKQQP VLVGTVSIEK SELLSDMLKR KGVPHQVLNA KYHEKEAEII SHAGEKGMVT 

       490        500        510        520        530        540 
IATNMAGRGT DIKLGEGVEE VGGLKVIGTE RHESRRIDNQ LRGRSGRQGD PGYSRFYVSL 

       550        560        570        580        590        600 
EDDLMRIFAS DRLQGVVEKL GLTDEDAIES RMVSNAIENA QKKVEGNNFD VRKSVLQYDD 

       610        620        630        640        650        660 
VMNQQREVIY KQRSQVLEGE SLKEDIQEMI RSVISEAVDA HMSGLDETLE EDLEKLLAYL 

       670        680        690        700        710        720 
QEIYLPKNVV TVDELKIKSD DEIKEILIDI AEKMYSEKEE EVTPERMREI ESVILLRIVD 

       730        740        750        760        770        780 
TKWMDHIDNM DHLRQGMGLR AYRQQDPVQA YQFEGSEMFD EMINGIKTDT VKYLFHIQVE 

       790        800        810        820        830 
KNIERERVAR ETSTNINDGE GGSHEPIKRK EEKIGRNDLC PCGSGKKYKN CCGR 

« Hide

References

[1]"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT."
Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S.
Nat. Biotechnol. 24:1573-1580(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000382 Genomic DNA. Translation: ABK61305.1.
RefSeqYP_878979.1. NC_008593.1.

3D structure databases

ProteinModelPortalA0Q2X7.
SMRA0Q2X7. Positions 1-796.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING386415.NT01CX_0509.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK61305; ABK61305; NT01CX_0509.
GeneID4541153.
KEGGcno:NT01CX_0509.
PATRIC19481574. VBICloNov112828_2018.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0653.
HOGENOMHOG000218169.
KOK03070.
OMAEFQEIYG.
OrthoDBEOG654P48.
ProtClustDBPRK12904.

Enzyme and pathway databases

BioCycCNOV386415:GH98-2073-MONOMER.

Family and domain databases

Gene3D1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPMF_01382. SecA.
InterProIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSPR00906. SECA.
SMARTSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsTIGR00963. secA. 1 hit.
PROSITEPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSECA_CLONN
AccessionPrimary (citable) accession number: A0Q2X7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families