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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Clostridium novyi (strain NT)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi820 – 8201ZincUniRule annotation
Metal bindingi822 – 8221ZincUniRule annotation
Metal bindingi831 – 8311ZincUniRule annotation
Metal bindingi832 – 8321ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1078ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCNOV386415:GH98-2073-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:NT01CX_0509
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Protein translocase subunit SecAPRO_0000320781Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi386415.NT01CX_0509.

Structurei

3D structure databases

ProteinModelPortaliA0Q2X7.
SMRiA0Q2X7. Positions 1-796.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218169.
KOiK03070.
OMAiERFFILQ.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q2X7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLFEKIFGT YSSREIKKII PIINKIDSYE EEFKKLTDEE LRNKTDEFKD
60 70 80 90 100
MLAKGKTLDD ILPEAFAVAR EASARVLGMR HFREQLIGGI VLHQGRISEM
110 120 130 140 150
KTGEGKTLVA TLPAYLNALS GKGVHVITVN DYLAKRDRDQ MSQLYGFLGL
160 170 180 190 200
TTGVIVHDLD NEQRREAYNC DITYGTNNEF GFDYLRDNMV IYKEERVQRK
210 220 230 240 250
LNFCIVDEVD SILIDEARTP LIISGEGDNS TDFYKVADFF AKTLKEDDYT
260 270 280 290 300
VDEKTNSVIL TEQGIEKAEK FFHIDNYGDG DNMQIQHHVV QALKANYTMK
310 320 330 340 350
RDKDYMVKDN EVIIVDEFTG RLMEGRRYSD GLHQAIEAKE NVKIQKESKT
360 370 380 390 400
LATITFQNYF RMYTKLSGMT GTAQTEEAEF REIYGLDVIV IPTHRPIARI
410 420 430 440 450
DAPDVVYKSE KAKFKAIVNE IAETYKKQQP VLVGTVSIEK SELLSDMLKR
460 470 480 490 500
KGVPHQVLNA KYHEKEAEII SHAGEKGMVT IATNMAGRGT DIKLGEGVEE
510 520 530 540 550
VGGLKVIGTE RHESRRIDNQ LRGRSGRQGD PGYSRFYVSL EDDLMRIFAS
560 570 580 590 600
DRLQGVVEKL GLTDEDAIES RMVSNAIENA QKKVEGNNFD VRKSVLQYDD
610 620 630 640 650
VMNQQREVIY KQRSQVLEGE SLKEDIQEMI RSVISEAVDA HMSGLDETLE
660 670 680 690 700
EDLEKLLAYL QEIYLPKNVV TVDELKIKSD DEIKEILIDI AEKMYSEKEE
710 720 730 740 750
EVTPERMREI ESVILLRIVD TKWMDHIDNM DHLRQGMGLR AYRQQDPVQA
760 770 780 790 800
YQFEGSEMFD EMINGIKTDT VKYLFHIQVE KNIERERVAR ETSTNINDGE
810 820 830
GGSHEPIKRK EEKIGRNDLC PCGSGKKYKN CCGR
Length:834
Mass (Da):95,455
Last modified:January 9, 2007 - v1
Checksum:i0F58ACF6A12C0CE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA. Translation: ABK61305.1.
RefSeqiWP_011722960.1. NC_008593.1.
YP_878979.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK61305; ABK61305; NT01CX_0509.
GeneIDi4541153.
KEGGicno:NT01CX_0509.
PATRICi19481574. VBICloNov112828_2018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA. Translation: ABK61305.1.
RefSeqiWP_011722960.1. NC_008593.1.
YP_878979.1. NC_008593.1.

3D structure databases

ProteinModelPortaliA0Q2X7.
SMRiA0Q2X7. Positions 1-796.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi386415.NT01CX_0509.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK61305; ABK61305; NT01CX_0509.
GeneIDi4541153.
KEGGicno:NT01CX_0509.
PATRICi19481574. VBICloNov112828_2018.

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218169.
KOiK03070.
OMAiERFFILQ.
OrthoDBiEOG654P48.

Enzyme and pathway databases

BioCyciCNOV386415:GH98-2073-MONOMER.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiSECA_CLONN
AccessioniPrimary (citable) accession number: A0Q2X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: May 27, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.