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A0Q2X7

- SECA_CLONN

UniProt

A0Q2X7 - SECA_CLONN

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Protein

Protein translocase subunit SecA

Gene
secA, NT01CX_0509
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity.UniRule annotation

Cofactori

May bind 1 zinc ion per subunit Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi820 – 8201Zinc Reviewed prediction
Metal bindingi822 – 8221Zinc Reviewed prediction
Metal bindingi831 – 8311Zinc Reviewed prediction
Metal bindingi832 – 8321Zinc Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1078ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein import Source: InterPro
  3. protein targeting Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCNOV386415:GH98-2073-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA
Gene namesi
Name:secA
Ordered Locus Names:NT01CX_0509
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

Subcellular locationi

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity
Note: Distribution is 50-50 By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Protein translocase subunit SecAUniRule annotationPRO_0000320781Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi386415.NT01CX_0509.

Structurei

3D structure databases

ProteinModelPortaliA0Q2X7.
SMRiA0Q2X7. Positions 1-796.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218169.
KOiK03070.
OMAiEAYEFQQ.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q2X7-1 [UniParc]FASTAAdd to Basket

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MGLFEKIFGT YSSREIKKII PIINKIDSYE EEFKKLTDEE LRNKTDEFKD    50
MLAKGKTLDD ILPEAFAVAR EASARVLGMR HFREQLIGGI VLHQGRISEM 100
KTGEGKTLVA TLPAYLNALS GKGVHVITVN DYLAKRDRDQ MSQLYGFLGL 150
TTGVIVHDLD NEQRREAYNC DITYGTNNEF GFDYLRDNMV IYKEERVQRK 200
LNFCIVDEVD SILIDEARTP LIISGEGDNS TDFYKVADFF AKTLKEDDYT 250
VDEKTNSVIL TEQGIEKAEK FFHIDNYGDG DNMQIQHHVV QALKANYTMK 300
RDKDYMVKDN EVIIVDEFTG RLMEGRRYSD GLHQAIEAKE NVKIQKESKT 350
LATITFQNYF RMYTKLSGMT GTAQTEEAEF REIYGLDVIV IPTHRPIARI 400
DAPDVVYKSE KAKFKAIVNE IAETYKKQQP VLVGTVSIEK SELLSDMLKR 450
KGVPHQVLNA KYHEKEAEII SHAGEKGMVT IATNMAGRGT DIKLGEGVEE 500
VGGLKVIGTE RHESRRIDNQ LRGRSGRQGD PGYSRFYVSL EDDLMRIFAS 550
DRLQGVVEKL GLTDEDAIES RMVSNAIENA QKKVEGNNFD VRKSVLQYDD 600
VMNQQREVIY KQRSQVLEGE SLKEDIQEMI RSVISEAVDA HMSGLDETLE 650
EDLEKLLAYL QEIYLPKNVV TVDELKIKSD DEIKEILIDI AEKMYSEKEE 700
EVTPERMREI ESVILLRIVD TKWMDHIDNM DHLRQGMGLR AYRQQDPVQA 750
YQFEGSEMFD EMINGIKTDT VKYLFHIQVE KNIERERVAR ETSTNINDGE 800
GGSHEPIKRK EEKIGRNDLC PCGSGKKYKN CCGR 834
Length:834
Mass (Da):95,455
Last modified:January 9, 2007 - v1
Checksum:i0F58ACF6A12C0CE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61305.1.
RefSeqiYP_878979.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK61305; ABK61305; NT01CX_0509.
GeneIDi4541153.
KEGGicno:NT01CX_0509.
PATRICi19481574. VBICloNov112828_2018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61305.1 .
RefSeqi YP_878979.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0Q2X7.
SMRi A0Q2X7. Positions 1-796.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_0509.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK61305 ; ABK61305 ; NT01CX_0509 .
GeneIDi 4541153.
KEGGi cno:NT01CX_0509.
PATRICi 19481574. VBICloNov112828_2018.

Phylogenomic databases

eggNOGi COG0653.
HOGENOMi HOG000218169.
KOi K03070.
OMAi EAYEFQQ.
OrthoDBi EOG654P48.

Enzyme and pathway databases

BioCyci CNOV386415:GH98-2073-MONOMER.

Family and domain databases

Gene3Di 1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPi MF_01382. SecA.
InterProi IPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view ]
Pfami PF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view ]
PRINTSi PR00906. SECA.
SMARTi SM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsi TIGR00963. secA. 1 hit.
PROSITEi PS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiSECA_CLONN
AccessioniPrimary (citable) accession number: A0Q2X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi