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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Clostridium novyi (strain NT)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi820ZincUniRule annotation1
Metal bindingi822ZincUniRule annotation1
Metal bindingi831ZincUniRule annotation1
Metal bindingi832ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:NT01CX_0509
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000008220 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003207811 – 834Protein translocase subunit SecAAdd BLAST834

Proteomic databases

PRIDEiA0Q2X7

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi386415.NT01CX_0509

Structurei

3D structure databases

ProteinModelPortaliA0Q2X7
SMRiA0Q2X7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
HOGENOMiHOG000218169
KOiK03070
OMAiFEYDEVM
OrthoDBiPOG091H01RS

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR004027 SEC_C_motif
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF02810 SEC-C, 1 hit
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

A0Q2X7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLFEKIFGT YSSREIKKII PIINKIDSYE EEFKKLTDEE LRNKTDEFKD
60 70 80 90 100
MLAKGKTLDD ILPEAFAVAR EASARVLGMR HFREQLIGGI VLHQGRISEM
110 120 130 140 150
KTGEGKTLVA TLPAYLNALS GKGVHVITVN DYLAKRDRDQ MSQLYGFLGL
160 170 180 190 200
TTGVIVHDLD NEQRREAYNC DITYGTNNEF GFDYLRDNMV IYKEERVQRK
210 220 230 240 250
LNFCIVDEVD SILIDEARTP LIISGEGDNS TDFYKVADFF AKTLKEDDYT
260 270 280 290 300
VDEKTNSVIL TEQGIEKAEK FFHIDNYGDG DNMQIQHHVV QALKANYTMK
310 320 330 340 350
RDKDYMVKDN EVIIVDEFTG RLMEGRRYSD GLHQAIEAKE NVKIQKESKT
360 370 380 390 400
LATITFQNYF RMYTKLSGMT GTAQTEEAEF REIYGLDVIV IPTHRPIARI
410 420 430 440 450
DAPDVVYKSE KAKFKAIVNE IAETYKKQQP VLVGTVSIEK SELLSDMLKR
460 470 480 490 500
KGVPHQVLNA KYHEKEAEII SHAGEKGMVT IATNMAGRGT DIKLGEGVEE
510 520 530 540 550
VGGLKVIGTE RHESRRIDNQ LRGRSGRQGD PGYSRFYVSL EDDLMRIFAS
560 570 580 590 600
DRLQGVVEKL GLTDEDAIES RMVSNAIENA QKKVEGNNFD VRKSVLQYDD
610 620 630 640 650
VMNQQREVIY KQRSQVLEGE SLKEDIQEMI RSVISEAVDA HMSGLDETLE
660 670 680 690 700
EDLEKLLAYL QEIYLPKNVV TVDELKIKSD DEIKEILIDI AEKMYSEKEE
710 720 730 740 750
EVTPERMREI ESVILLRIVD TKWMDHIDNM DHLRQGMGLR AYRQQDPVQA
760 770 780 790 800
YQFEGSEMFD EMINGIKTDT VKYLFHIQVE KNIERERVAR ETSTNINDGE
810 820 830
GGSHEPIKRK EEKIGRNDLC PCGSGKKYKN CCGR
Length:834
Mass (Da):95,455
Last modified:January 9, 2007 - v1
Checksum:i0F58ACF6A12C0CE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA Translation: ABK61305.1
RefSeqiWP_011722960.1, NC_008593.1

Genome annotation databases

EnsemblBacteriaiABK61305; ABK61305; NT01CX_0509
GeneIDi4541153
KEGGicno:NT01CX_0509

Similar proteinsi

Entry informationi

Entry nameiSECA_CLONN
AccessioniPrimary (citable) accession number: A0Q2X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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