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A0Q2X7

- SECA_CLONN

UniProt

A0Q2X7 - SECA_CLONN

Protein

Protein translocase subunit SecA

Gene

secA

Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

    Cofactori

    May bind 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi820 – 8201ZincUniRule annotation
    Metal bindingi822 – 8221ZincUniRule annotation
    Metal bindingi831 – 8311ZincUniRule annotation
    Metal bindingi832 – 8321ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi100 – 1078ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein import Source: InterPro
    3. protein targeting Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciCNOV386415:GH98-2073-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecAUniRule annotation
    Gene namesi
    Name:secAUniRule annotation
    Ordered Locus Names:NT01CX_0509
    OrganismiClostridium novyi (strain NT)
    Taxonomic identifieri386415 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000008220: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation. Cytoplasm UniRule annotation
    Note: Distribution is 50-50.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Protein translocase subunit SecAPRO_0000320781Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

    Protein-protein interaction databases

    STRINGi386415.NT01CX_0509.

    Structurei

    3D structure databases

    ProteinModelPortaliA0Q2X7.
    SMRiA0Q2X7. Positions 1-796.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0653.
    HOGENOMiHOG000218169.
    KOiK03070.
    OMAiEAYEFQQ.
    OrthoDBiEOG654P48.

    Family and domain databases

    Gene3Di1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPiMF_01382. SecA.
    InterProiIPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view]
    PfamiPF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view]
    PRINTSiPR00906. SECA.
    SMARTiSM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 1 hit.
    TIGRFAMsiTIGR00963. secA. 1 hit.
    PROSITEiPS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0Q2X7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLFEKIFGT YSSREIKKII PIINKIDSYE EEFKKLTDEE LRNKTDEFKD    50
    MLAKGKTLDD ILPEAFAVAR EASARVLGMR HFREQLIGGI VLHQGRISEM 100
    KTGEGKTLVA TLPAYLNALS GKGVHVITVN DYLAKRDRDQ MSQLYGFLGL 150
    TTGVIVHDLD NEQRREAYNC DITYGTNNEF GFDYLRDNMV IYKEERVQRK 200
    LNFCIVDEVD SILIDEARTP LIISGEGDNS TDFYKVADFF AKTLKEDDYT 250
    VDEKTNSVIL TEQGIEKAEK FFHIDNYGDG DNMQIQHHVV QALKANYTMK 300
    RDKDYMVKDN EVIIVDEFTG RLMEGRRYSD GLHQAIEAKE NVKIQKESKT 350
    LATITFQNYF RMYTKLSGMT GTAQTEEAEF REIYGLDVIV IPTHRPIARI 400
    DAPDVVYKSE KAKFKAIVNE IAETYKKQQP VLVGTVSIEK SELLSDMLKR 450
    KGVPHQVLNA KYHEKEAEII SHAGEKGMVT IATNMAGRGT DIKLGEGVEE 500
    VGGLKVIGTE RHESRRIDNQ LRGRSGRQGD PGYSRFYVSL EDDLMRIFAS 550
    DRLQGVVEKL GLTDEDAIES RMVSNAIENA QKKVEGNNFD VRKSVLQYDD 600
    VMNQQREVIY KQRSQVLEGE SLKEDIQEMI RSVISEAVDA HMSGLDETLE 650
    EDLEKLLAYL QEIYLPKNVV TVDELKIKSD DEIKEILIDI AEKMYSEKEE 700
    EVTPERMREI ESVILLRIVD TKWMDHIDNM DHLRQGMGLR AYRQQDPVQA 750
    YQFEGSEMFD EMINGIKTDT VKYLFHIQVE KNIERERVAR ETSTNINDGE 800
    GGSHEPIKRK EEKIGRNDLC PCGSGKKYKN CCGR 834
    Length:834
    Mass (Da):95,455
    Last modified:January 9, 2007 - v1
    Checksum:i0F58ACF6A12C0CE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK61305.1.
    RefSeqiYP_878979.1. NC_008593.1.

    Genome annotation databases

    EnsemblBacteriaiABK61305; ABK61305; NT01CX_0509.
    GeneIDi4541153.
    KEGGicno:NT01CX_0509.
    PATRICi19481574. VBICloNov112828_2018.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK61305.1 .
    RefSeqi YP_878979.1. NC_008593.1.

    3D structure databases

    ProteinModelPortali A0Q2X7.
    SMRi A0Q2X7. Positions 1-796.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386415.NT01CX_0509.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK61305 ; ABK61305 ; NT01CX_0509 .
    GeneIDi 4541153.
    KEGGi cno:NT01CX_0509.
    PATRICi 19481574. VBICloNov112828_2018.

    Phylogenomic databases

    eggNOGi COG0653.
    HOGENOMi HOG000218169.
    KOi K03070.
    OMAi EAYEFQQ.
    OrthoDBi EOG654P48.

    Enzyme and pathway databases

    BioCyci CNOV386415:GH98-2073-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPi MF_01382. SecA.
    InterProi IPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view ]
    Pfami PF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view ]
    PRINTSi PR00906. SECA.
    SMARTi SM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 1 hit.
    TIGRFAMsi TIGR00963. secA. 1 hit.
    PROSITEi PS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NT.

    Entry informationi

    Entry nameiSECA_CLONN
    AccessioniPrimary (citable) accession number: A0Q2X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3