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A0Q2N3

- PYRF_CLONN

UniProt

A0Q2N3 - PYRF_CLONN

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, NT01CX_0393
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCNOV386415:GH98-1957-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:NT01CX_0393
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_1000066464Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_0393.

Structurei

3D structure databases

ProteinModelPortaliA0Q2N3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCRTSNAG.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0Q2N3-1 [UniParc]FASTAAdd to Basket

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MVLIIDRLYE EVNKKGNVCV GLDTDLSYIP QRFLKNYENI EDAIFQFNRK    50
IIDATHDAVA CYKVQIAYYE SFGLKGLMAY KRTLEYIKKV GCIAISDVKR 100
GDISKTAEMY AKAHFEGDFE TDFITVNPYM GMDSIEPYMP YLQNKEKGLF 150
ALVRTSNPGS KDFEYIQSGS GRRVYEIVGE KLERLGEKVM GQCGYSSIGG 200
VVGCTTLEDG KEIRKNFGKT FFLIPGFGAQ GGGAKEANVY LKDGNGGVVN 250
SSRGILLAYK KYENGEKNFD ECSRKEVLKM QKELGRE 287
Length:287
Mass (Da):32,269
Last modified:January 9, 2007 - v1
Checksum:i60464FD53A1E39D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK62436.1.
RefSeqiYP_878885.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK62436; ABK62436; NT01CX_0393.
GeneIDi4540597.
KEGGicno:NT01CX_0393.
PATRICi19481330. VBICloNov112828_1918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK62436.1 .
RefSeqi YP_878885.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0Q2N3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_0393.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK62436 ; ABK62436 ; NT01CX_0393 .
GeneIDi 4540597.
KEGGi cno:NT01CX_0393.
PATRICi 19481330. VBICloNov112828_1918.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi CRTSNAG.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CNOV386415:GH98-1957-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiPYRF_CLONN
AccessioniPrimary (citable) accession number: A0Q2N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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