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A0Q2N3

- PYRF_CLONN

UniProt

A0Q2N3 - PYRF_CLONN

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei99 – 991Proton donorUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciCNOV386415:GH98-1957-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:NT01CX_0393
    OrganismiClostridium novyi (strain NT)
    Taxonomic identifieri386415 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000008220: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Orotidine 5'-phosphate decarboxylasePRO_1000066464Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi386415.NT01CX_0393.

    Structurei

    3D structure databases

    ProteinModelPortaliA0Q2N3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000245747.
    KOiK01591.
    OMAiCRTSNAG.
    OrthoDBiEOG6DZF33.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0Q2N3-1 [UniParc]FASTAAdd to Basket

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    MVLIIDRLYE EVNKKGNVCV GLDTDLSYIP QRFLKNYENI EDAIFQFNRK    50
    IIDATHDAVA CYKVQIAYYE SFGLKGLMAY KRTLEYIKKV GCIAISDVKR 100
    GDISKTAEMY AKAHFEGDFE TDFITVNPYM GMDSIEPYMP YLQNKEKGLF 150
    ALVRTSNPGS KDFEYIQSGS GRRVYEIVGE KLERLGEKVM GQCGYSSIGG 200
    VVGCTTLEDG KEIRKNFGKT FFLIPGFGAQ GGGAKEANVY LKDGNGGVVN 250
    SSRGILLAYK KYENGEKNFD ECSRKEVLKM QKELGRE 287
    Length:287
    Mass (Da):32,269
    Last modified:January 9, 2007 - v1
    Checksum:i60464FD53A1E39D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK62436.1.
    RefSeqiYP_878885.1. NC_008593.1.

    Genome annotation databases

    EnsemblBacteriaiABK62436; ABK62436; NT01CX_0393.
    GeneIDi4540597.
    KEGGicno:NT01CX_0393.
    PATRICi19481330. VBICloNov112828_1918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK62436.1 .
    RefSeqi YP_878885.1. NC_008593.1.

    3D structure databases

    ProteinModelPortali A0Q2N3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386415.NT01CX_0393.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK62436 ; ABK62436 ; NT01CX_0393 .
    GeneIDi 4540597.
    KEGGi cno:NT01CX_0393.
    PATRICi 19481330. VBICloNov112828_1918.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000245747.
    KOi K01591.
    OMAi CRTSNAG.
    OrthoDBi EOG6DZF33.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci CNOV386415:GH98-1957-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NT.

    Entry informationi

    Entry nameiPYRF_CLONN
    AccessioniPrimary (citable) accession number: A0Q2N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3