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A0Q2J7

- TRMB_CLONN

UniProt

A0Q2J7 - TRMB_CLONN

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, NT01CX_0357
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451S-adenosyl-L-methionine By similarity
Binding sitei70 – 701S-adenosyl-L-methionine By similarity
Binding sitei97 – 971S-adenosyl-L-methionine By similarity
Binding sitei119 – 1191S-adenosyl-L-methionine By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei155 – 1551Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCNOV386415:GH98-1921-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:NT01CX_0357
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000288139Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_0357.

Structurei

3D structure databases

ProteinModelPortaliA0Q2J7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1306Interaction with RNA Reviewed prediction
Regioni193 – 1964Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q2J7-1 [UniParc]FASTAAdd to Basket

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MRLRKKWWAR PELEASPIFK SLDEARELKG NWKDEFKNNN DIYLELGCGR    50
GGFAVQAASK FNDKNLISID LKDEVLVYAL KNIVDAELEN VRLVAMNIGM 100
IAEIFDENEI SRIYINFCNP WPKDRHNKRR LTHTRFLTEY KKFIKPGTEI 150
HFKTDDLDLF NDSLVYFEES GFELLYKTYD LHNSDYADEN LMTEYETKFK 200
EKGIKSKFLI AKLK 214
Length:214
Mass (Da):25,311
Last modified:January 9, 2007 - v1
Checksum:i791E2906137F5219
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK62412.1.
RefSeqiWP_011722833.1. NC_008593.1.
YP_878849.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK62412; ABK62412; NT01CX_0357.
GeneIDi4541349.
KEGGicno:NT01CX_0357.
PATRICi19481256. VBICloNov112828_1881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK62412.1 .
RefSeqi WP_011722833.1. NC_008593.1.
YP_878849.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0Q2J7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_0357.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK62412 ; ABK62412 ; NT01CX_0357 .
GeneIDi 4541349.
KEGGi cno:NT01CX_0357.
PATRICi 19481256. VBICloNov112828_1881.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CNOV386415:GH98-1921-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiTRMB_CLONN
AccessioniPrimary (citable) accession number: A0Q2J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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