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A0Q2A8

- GSA_CLONN

UniProt

A0Q2A8 - GSA_CLONN

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, NT01CX_0259
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCNOV386415:GH98-1825-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:NT01CX_0259
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000382297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA0Q2A8.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi386415.NT01CX_0259.

Structurei

3D structure databases

ProteinModelPortaliA0Q2A8.
SMRiA0Q2A8. Positions 5-428.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q2A8-1 [UniParc]FASTAAdd to Basket

« Hide

MKELKHTKSE AMFKEAVKYI PGGVNSPVRA FGSVGLNPIF IDRAKGSKIY    50
DVDGNEYIDY ICSWGPLILG HSNEKLYEGI EETLRRGTSY GVPTEIEVKM 100
AKLITEAYPS VDMVRMVNSG TEATMSALRV ARGYTRRNKI LKFEGCYHGH 150
SDALLVKSGS GTITFGVPTS PGVPEGTVKD TLVCRYNDIE AVKRIFQEQG 200
NEIAAVIVEP VSGNMGVVPG KQEFLQFLRD ITKEYKSVLI FDEVITGFRL 250
AYGGAQEVYG IEADMTCFGK IIGAGLPVGA YGGKREIMEC VSPMGPVYQA 300
GTLSGNPLAM HMGYKNLNIL KENKDVYERL EEKAKRLEEG FNKNIKELGI 350
KATVVRFKAM LCLFFAEGPL NNYDEVSKCD TEMYAKYFGE MLKRGVLIAP 400
AQFEALFLSD AHTDEDIEYT IKANYEALKE LKC 433
Length:433
Mass (Da):48,017
Last modified:January 9, 2007 - v1
Checksum:i0B8807175180523E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK62364.1.
RefSeqiWP_011722747.1. NC_008593.1.
YP_878760.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK62364; ABK62364; NT01CX_0259.
GeneIDi4539751.
KEGGicno:NT01CX_0259.
PATRICi19481066. VBICloNov112828_1795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK62364.1 .
RefSeqi WP_011722747.1. NC_008593.1.
YP_878760.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0Q2A8.
SMRi A0Q2A8. Positions 5-428.
ModBasei Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_0259.

Proteomic databases

PRIDEi A0Q2A8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK62364 ; ABK62364 ; NT01CX_0259 .
GeneIDi 4539751.
KEGGi cno:NT01CX_0259.
PATRICi 19481066. VBICloNov112828_1795.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci CNOV386415:GH98-1825-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiGSA_CLONN
AccessioniPrimary (citable) accession number: A0Q2A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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