Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A0Q210 (UPPP_CLONN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:NT01CX_0158
OrganismClostridium novyi (strain NT) [Complete proteome] [HAMAP]
Taxonomic identifier386415 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290700

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane264 – 28421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A0Q210 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 1BFBCEFBCAD5C962

FASTA28631,650
        10         20         30         40         50         60 
MENLWFIIKA IIIGIVEGIT EFLPVSSTGH MIIVEDLINF KEGVMPASLY TKQYIDAFTM 

        70         80         90        100        110        120 
IIQLGAILAI VVLYWDKIKR SFENFAPSKP KSGFKFWLNI AVSAVPAGVL GLKFHSKINE 

       130        140        150        160        170        180 
KLFNPGSVTA ALIVGAIWMI FAEKRYRGKF TTKDIDNVTI KQAFIIGCFQ CLALWPGMSR 

       190        200        210        220        230        240 
SASTIIGAWI VGLSTVAAAE FSFFLALPVM AGVTYKSLKD INVFALGSMH IVGLTVGFIV 

       250        260        270        280 
SFIVALIVVD KFITFLKKKP MRVFAMYRIL LGIVLIILSL FNVISM 

« Hide

References

[1]"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT."
Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S.
Nat. Biotechnol. 24:1573-1580(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000382 Genomic DNA. Translation: ABK61243.1.
RefSeqYP_878662.1. NC_008593.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING386415.NT01CX_0158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK61243; ABK61243; NT01CX_0158.
GeneID4540714.
KEGGcno:NT01CX_0158.
PATRIC19480856. VBICloNov112828_1693.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAVIYFRNE.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCNOV386415:GH98-1725-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CLONN
AccessionPrimary (citable) accession number: A0Q210
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families