A0Q210 (UPPP_CLONN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	NT01CX_0158

Organism

Clostridium novyi (strain NT) [Complete proteome] [HAMAP]

Taxonomic identifier

386415 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium novyi

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000290700
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Transmembrane	122 – 142	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	229 – 249	21	Helical; Potential
	Transmembrane	264 – 284	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A0Q210 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 1BFBCEFBCAD5C962	FASTA	286	31,650
	10 20 30 40 50 60 MENLWFIIKA IIIGIVEGIT EFLPVSSTGH MIIVEDLINF KEGVMPASLY TKQYIDAFTM 70 80 90 100 110 120 IIQLGAILAI VVLYWDKIKR SFENFAPSKP KSGFKFWLNI AVSAVPAGVL GLKFHSKINE 130 140 150 160 170 180 KLFNPGSVTA ALIVGAIWMI FAEKRYRGKF TTKDIDNVTI KQAFIIGCFQ CLALWPGMSR 190 200 210 220 230 240 SASTIIGAWI VGLSTVAAAE FSFFLALPVM AGVTYKSLKD INVFALGSMH IVGLTVGFIV 250 260 270 280 SFIVALIVVD KFITFLKKKP MRVFAMYRIL LGIVLIILSL FNVISM

References

[1]

"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT." Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S. Nat. Biotechnol. 24:1573-1580(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000382 Genomic DNA. Translation: ABK61243.1.
RefSeq	YP_878662.1. NC_008593.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	386415.NT01CX_0158.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK61243; ABK61243; NT01CX_0158.
GeneID	4540714.
KEGG	cno:NT01CX_0158.
PATRIC	19480856. VBICloNov112828_1693.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	TGHQLLI.
ProtClustDB	PRK12554.
Enzyme and pathway databases
BioCyc	CNOV386415:GH98-1799-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_CLONN

Accession

Primary (citable) accession number: A0Q210

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program