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A0Q1Z2

- ASSY_CLONN

UniProt

A0Q1Z2 - ASSY_CLONN

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Protein

Argininosuccinate synthase

Gene
argG, NT01CX_0135
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861Citrulline By similarity
Binding sitei91 – 911Citrulline By similarity
Binding sitei116 – 1161ATP; via amide nitrogen By similarity
Binding sitei118 – 1181Aspartate By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei122 – 1221Citrulline By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei175 – 1751Citrulline By similarity
Binding sitei184 – 1841Citrulline By similarity
Binding sitei260 – 2601Citrulline By similarity
Binding sitei272 – 2721Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNOV386415:GH98-1703-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:NT01CX_0135
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Argininosuccinate synthaseUniRule annotationPRO_1000000393Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi386415.NT01CX_0135.

Structurei

3D structure databases

ProteinModelPortaliA0Q1Z2.
SMRiA0Q1Z2. Positions 4-396.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q1Z2-1 [UniParc]FASTAAdd to Basket

« Hide

MKEKVVLAYS GGLDTSITIH WLKENYNLDV IACCVNVGQD EDFDEIKKKA    50
IKSGATKIYV EDVKDEFVSE YIYKGVKANA VYEGKYLLGT SFARPLIAKK 100
LVEVAHKEGA KYICHGCTGK GNDQVRFEVG IMSLDPSIKV IAPWRIWNIK 150
SREDAVDYAN ANGIEVPVTK EKIYSRDQNL WHISHEGGDL ENIRNEHKTD 200
MYCMTVPPEK AKDEVSYIKI TFEKGEAKKL DDVEMSPVEI LEKLNKIGGE 250
NGIGVIDLLE NRLVGMKSRG VYETPGGTIL YAAHKELEYL TMQKETFHFK 300
QMVSQKYGEL VYNGLWFSTL KESLDAFIDK TQEVVNGTVR LKLYKGNIMV 350
AGMESPNALY EESISSFGAS DFYDHKDAEG FINLFGLPYK INAMIQLKNQ 400
EN 402
Length:402
Mass (Da):45,413
Last modified:January 9, 2007 - v1
Checksum:i7882A75E040103AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61403.1.
RefSeqiYP_878644.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK61403; ABK61403; NT01CX_0135.
GeneIDi4540890.
KEGGicno:NT01CX_0135.
PATRICi19480812. VBICloNov112828_1676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61403.1 .
RefSeqi YP_878644.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0Q1Z2.
SMRi A0Q1Z2. Positions 4-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_0135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK61403 ; ABK61403 ; NT01CX_0135 .
GeneIDi 4540890.
KEGGi cno:NT01CX_0135.
PATRICi 19480812. VBICloNov112828_1676.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci CNOV386415:GH98-1703-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiASSY_CLONN
AccessioniPrimary (citable) accession number: A0Q1Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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