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Protein

Quinolinate synthase A

Gene

nadA

Organism
Clostridium novyi (strain NT)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.UniRule annotation

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase A (nadA)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei23IminoaspartateUniRule annotation1
Binding sitei40Iminoaspartate; via amide nitrogenUniRule annotation1
Binding sitei111IminoaspartateUniRule annotation1
Binding sitei128IminoaspartateUniRule annotation1
Binding sitei198IminoaspartateUniRule annotation1
Binding sitei215IminoaspartateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00327.

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthase AUniRule annotation (EC:2.5.1.72UniRule annotation)
Gene namesi
Name:nadAUniRule annotation
Ordered Locus Names:NT01CX_0090
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000008220 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000611511 – 300Quinolinate synthase AAdd BLAST300

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_0090.

Structurei

3D structure databases

ProteinModelPortaliA0Q1U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the quinolinate synthase A family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0I. Bacteria.
COG0379. LUCA.
HOGENOMiHOG000222770.
KOiK03517.
OMAiIAHPECE.
OrthoDBiPOG091H03D2.

Family and domain databases

HAMAPiMF_00568. NadA_type2. 1 hit.
InterProiIPR003473. NadA.
IPR023066. Quinolinate_synth_type2.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0Q1U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIDLKDKIM KLKKEKNAVI LAHFYQPKDV QEVADYIGDS YFLIDVGEKC
60 70 80 90 100
KEDTIVFCGV KFMAESAKIL SPNKKVIFPT PKAICPMANM ITKEDVLKLK
110 120 130 140 150
EKHPNAKVVC YINSTAEVKS VVDVCCTSSN AIEIVNNLES NEIIFLPDKN
160 170 180 190 200
LGSYIQENTP NKKIILWDGY CYVHNKIKAS DIIKAKEEYG NDINVLVHPE
210 220 230 240 250
CRKEVRELAD YIGSTKGIIN FAQNSNSKKY LIVTECGVIH ELKKKNPDKE
260 270 280 290 300
FYMLDMHCSN MKMNSIKEIY TCLKNYNNEV KIDENIKRKA VRALEKMHSL
Length:300
Mass (Da):34,330
Last modified:January 9, 2007 - v1
Checksum:i917FA0587993DA5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA. Translation: ABK62276.1.
RefSeqiWP_011722589.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK62276; ABK62276; NT01CX_0090.
KEGGicno:NT01CX_0090.
PATRICi19480720. VBICloNov112828_1630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA. Translation: ABK62276.1.
RefSeqiWP_011722589.1. NC_008593.1.

3D structure databases

ProteinModelPortaliA0Q1U7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi386415.NT01CX_0090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK62276; ABK62276; NT01CX_0090.
KEGGicno:NT01CX_0090.
PATRICi19480720. VBICloNov112828_1630.

Phylogenomic databases

eggNOGiENOG4105D0I. Bacteria.
COG0379. LUCA.
HOGENOMiHOG000222770.
KOiK03517.
OMAiIAHPECE.
OrthoDBiPOG091H03D2.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00327.

Family and domain databases

HAMAPiMF_00568. NadA_type2. 1 hit.
InterProiIPR003473. NadA.
IPR023066. Quinolinate_synth_type2.
[Graphical view]
PfamiPF02445. NadA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00550. nadA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADA_CLONN
AccessioniPrimary (citable) accession number: A0Q1U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.