A0Q1R4 (DNAK_CLONN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone protein DnaK

Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70

Gene names

Name:	dnaK
Ordered Locus Names:	NT01CX_0057

Organism

Clostridium novyi (strain NT) [Complete proteome] [HAMAP]

Taxonomic identifier

386415 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	617 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a chaperone By similarity. HAMAP MF_00332
Induction	By stress conditions e.g. heat shock By similarity. HAMAP MF_00332
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 617	617	Chaperone protein DnaK HAMAP MF_00332		PRO_1000059543
Amino acid modifications
	Modified residue	175	1	Phosphothreonine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0Q1R4 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 65399ED418A7303B	FASTA	617	66,306
	10 20 30 40 50 60 MGKIIGIDLG TTNSCVSVME GGNPVVIPNA EGSRTTPSVV AFKEDGERLV GQVAKRQAIT 70 80 90 100 110 120 NPDKTIISIK RHMGTDYRVN VDGKDYSPEE ISAMILQKLK ADAEAYLGET VTEAVITVPA 130 140 150 160 170 180 YFNDSERQAT KNAGKIAGLD VKRIINEPTA ASLAYGLDKM DKSHKIFVYD LGGGTFDVSI 190 200 210 220 230 240 LELGDGVFEV KATNGNTKLG GDDFDQKIMD YIAETFKAEN GIDLRNDKMA LQRLKEAAEK 250 260 270 280 290 300 AKIELSSSTK TNINLPFITA DATGPKHIDM DLTRAKFEEL SADLVQATIE PMKKALADAE 310 320 330 340 350 360 LTINDIDKVV LVGGSTRIPA VQEAVQKFTG KEPSKGVNPD EVVAMGAAVQ AGVLTGEVKD 370 380 390 400 410 420 ILLLDVTPLT LGIETMGGVA TPLIERNTTI PTRKSQIFST AADNQTSVDI HIVQGERKMA 430 440 450 460 470 480 GDNKTLGRFQ LSGIAPAPRG IPQIEVSFDI DANGILNVSA KDKGTGKEAN ITITASTNLS 490 500 510 520 530 540 DDEIDKAVKE AEKFAAEDEK RKESVEVKNN ADSALYQTEK ALKDLGDKVE EADKKNVEEK 550 560 570 580 590 600 LEALRQVKDG EDLEAIKKAT TELTEEFYKV SSKLYQQAGA EAQQGAQGTQ GADMGGNAQG 610 KDDDNVVDAD FKVEDDK

References

[1]

"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT." Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S. Nat. Biotechnol. 24:1573-1580(2006) [PubMed: 17115055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000382 Genomic DNA. Translation: ABK62104.1.
RefSeq	YP_878566.1. NC_008593.1.
3D structure databases
ProteinModelPortal	A0Q1R4.
SMR	A0Q1R4. Positions 1-507.
ModBase	Search...
Protein-protein interaction databases
STRING	A0Q1R4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4541654.
GenomeReviews	Gene locus NT01CX_0057 in contig CP000382_GR.
KEGG	cno:NT01CX_0057.
PATRIC	19480652. VBICloNov112828_1596.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0443.
HOGENOM	HBG334976.
OMA	ISMNASG.
ProtClustDB	PRK00290.
Enzyme and pathway databases
BioCyc	CNOV386415:NT01CX_0057-MONOMER.
Family and domain databases
HAMAP	MF_00332. DnaK. [Tree]
InterPro	IPR012725. Chaperone_DnaK. IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
KO	K04043.
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 2 hits. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
TIGRFAMs	TIGR02350. Prok_dnaK. 1 hit.
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAK_CLONN

Accession

Primary (citable) accession number: A0Q1R4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program