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A0Q1J3

- A0Q1J3_CLONN

UniProt

A0Q1J3 - A0Q1J3_CLONN

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Protein

Amidophosphoribosyltransferase

Gene

purF

Organism
Clostridium novyi (strain NT)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 4Fe-4S cluster per subunit.UniRule annotation
  • Note: Binds 1 magnesium ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131For GATase activityUniRule annotation

GO - Molecular functioni

  1. amidophosphoribosyltransferase activity Source: UniProtKB-EC
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. nucleoside metabolic process Source: InterPro
  3. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Keywords - Ligandi

Iron, Iron-sulfurUniRule annotation, MagnesiumUniRule annotation, Metal-binding

Enzyme and pathway databases

BioCyciCNOV386415:GH98-1554-MONOMER.
UniPathwayiUPA00074; UER00124.

Protein family/group databases

MEROPSiC44.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
AmidophosphoribosyltransferaseUniRule annotation (EC:2.4.2.14UniRule annotation)
Short name:
ATaseUniRule annotation
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferaseUniRule annotation
Gene namesi
Name:purFImported
Ordered Locus Names:NT01CX_2422Imported
OrganismiClostridium novyi (strain NT)Imported
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_2422.

Structurei

3D structure databases

ProteinModelPortaliA0Q1J3.
SMRiA0Q1J3. Positions 13-457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0034.
HOGENOMiHOG000033688.
KOiK00764.
OMAiSGIPYEM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProiIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01134. purF. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q1J3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKIEIDKFK DECGVFGIYS KSKLNVASVT YYGLYALQHR GEESAGIVVS
60 70 80 90 100
DGEKLTCIKD MGLVSDVFNE EIINNMKGKM AIGHVRYSTF GESTISNAQP
110 120 130 140 150
LLSSFKLGSI AIAHNGTLIN AEKIKQELEE KGVLFQTSID SEVILNLIAR
160 170 180 190 200
SLKSDIEESI KDAMKEVKGS YGIVILTKDK LIGVRDPNGI RPLCIGKMED
210 220 230 240 250
DYVICSESCA LNCIGAEFIR DVEPGEMVIV DENGLRSFKF EENIKHKTCA
260 270 280 290 300
FEYIYFARPD SKMDGIEVYN SRVAAGEQLF KEAPADADIV IGVPDSGIPA
310 320 330 340 350
AVGYAKASGI PYGIGLVKNK YVGRTFIAPS QDLRERAVSV KLSPLKVNVE
360 370 380 390 400
GKRVVLIDDS IVRGTTSRRL VEVLKRAGAK EIHFRLSSPV VTDPCYFGIA
410 420 430 440 450
TPYKKDLIGA NMSVDEICKE IGADSLGYLS IEGLLKVLKD GKDEFCLGCF

NGQYPVER
Length:458
Mass (Da):50,209
Last modified:January 9, 2007 - v1
Checksum:i6B73AA044023606A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA. Translation: ABK62149.1.
RefSeqiYP_878495.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK62149; ABK62149; NT01CX_2422.
GeneIDi4539783.
KEGGicno:NT01CX_2422.
PATRICi19480510. VBICloNov112828_1525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA. Translation: ABK62149.1 .
RefSeqi YP_878495.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0Q1J3.
SMRi A0Q1J3. Positions 13-457.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_2422.

Protein family/group databases

MEROPSi C44.A01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK62149 ; ABK62149 ; NT01CX_2422 .
GeneIDi 4539783.
KEGGi cno:NT01CX_2422.
PATRICi 19480510. VBICloNov112828_1525.

Phylogenomic databases

eggNOGi COG0034.
HOGENOMi HOG000033688.
KOi K00764.
OMAi SGIPYEM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00124 .
BioCyci CNOV386415:GH98-1554-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProi IPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF13537. GATase_7. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view ]
PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMi SSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01134. purF. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NTImported.

Entry informationi

Entry nameiA0Q1J3_CLONN
AccessioniPrimary (citable) accession number: A0Q1J3
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3