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A0Q1J3

- A0Q1J3_CLONN

UniProt

A0Q1J3 - A0Q1J3_CLONN

Protein

Amidophosphoribosyltransferase

Gene

purF

Organism
Clostridium novyi (strain NT)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster per subunit.UniRule annotation
    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei13 – 131For GATase activityUniRule annotation
    Metal bindingi249 – 2491Iron-sulfur (4Fe-4S)
    Metal bindingi395 – 3951Iron-sulfur (4Fe-4S)
    Metal bindingi446 – 4461Iron-sulfur (4Fe-4S)
    Metal bindingi449 – 4491Iron-sulfur (4Fe-4S)

    GO - Molecular functioni

    1. amidophosphoribosyltransferase activity Source: UniProtKB-EC
    2. iron-sulfur cluster binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
    2. nucleoside metabolic process Source: InterPro
    3. purine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    GlycosyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Purine biosynthesisUniRule annotation

    Keywords - Ligandi

    Iron, Iron-sulfurUniRule annotation, MagnesiumUniRule annotation, Metal-binding

    Enzyme and pathway databases

    BioCyciCNOV386415:GH98-1554-MONOMER.
    UniPathwayiUPA00074; UER00124.

    Protein family/group databases

    MEROPSiC44.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AmidophosphoribosyltransferaseUniRule annotation (EC:2.4.2.14UniRule annotation)
    Short name:
    ATaseUniRule annotation
    Alternative name(s):
    Glutamine phosphoribosylpyrophosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:purFImported
    Ordered Locus Names:NT01CX_2422Imported
    OrganismiClostridium novyi (strain NT)Imported
    Taxonomic identifieri386415 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000008220: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi386415.NT01CX_2422.

    Structurei

    3D structure databases

    ProteinModelPortaliA0Q1J3.
    SMRiA0Q1J3. Positions 13-457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0034.
    HOGENOMiHOG000033688.
    KOiK00764.
    OMAiSGIPYEM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    3.60.20.10. 1 hit.
    InterProiIPR005854. Amd_phspho_trans.
    IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR029055. Ntn_hydrolases_N.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF13537. GATase_7. 1 hit.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
    SUPFAMiSSF53271. SSF53271. 1 hit.
    SSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01134. purF. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0Q1J3-1 [UniParc]FASTAAdd to Basket

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    MNKIEIDKFK DECGVFGIYS KSKLNVASVT YYGLYALQHR GEESAGIVVS    50
    DGEKLTCIKD MGLVSDVFNE EIINNMKGKM AIGHVRYSTF GESTISNAQP 100
    LLSSFKLGSI AIAHNGTLIN AEKIKQELEE KGVLFQTSID SEVILNLIAR 150
    SLKSDIEESI KDAMKEVKGS YGIVILTKDK LIGVRDPNGI RPLCIGKMED 200
    DYVICSESCA LNCIGAEFIR DVEPGEMVIV DENGLRSFKF EENIKHKTCA 250
    FEYIYFARPD SKMDGIEVYN SRVAAGEQLF KEAPADADIV IGVPDSGIPA 300
    AVGYAKASGI PYGIGLVKNK YVGRTFIAPS QDLRERAVSV KLSPLKVNVE 350
    GKRVVLIDDS IVRGTTSRRL VEVLKRAGAK EIHFRLSSPV VTDPCYFGIA 400
    TPYKKDLIGA NMSVDEICKE IGADSLGYLS IEGLLKVLKD GKDEFCLGCF 450
    NGQYPVER 458
    Length:458
    Mass (Da):50,209
    Last modified:January 9, 2007 - v1
    Checksum:i6B73AA044023606A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK62149.1.
    RefSeqiWP_011722489.1. NC_008593.1.
    YP_878495.1. NC_008593.1.

    Genome annotation databases

    EnsemblBacteriaiABK62149; ABK62149; NT01CX_2422.
    GeneIDi4539783.
    KEGGicno:NT01CX_2422.
    PATRICi19480510. VBICloNov112828_1525.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK62149.1 .
    RefSeqi WP_011722489.1. NC_008593.1.
    YP_878495.1. NC_008593.1.

    3D structure databases

    ProteinModelPortali A0Q1J3.
    SMRi A0Q1J3. Positions 13-457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386415.NT01CX_2422.

    Protein family/group databases

    MEROPSi C44.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK62149 ; ABK62149 ; NT01CX_2422 .
    GeneIDi 4539783.
    KEGGi cno:NT01CX_2422.
    PATRICi 19480510. VBICloNov112828_1525.

    Phylogenomic databases

    eggNOGi COG0034.
    HOGENOMi HOG000033688.
    KOi K00764.
    OMAi SGIPYEM.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00124 .
    BioCyci CNOV386415:GH98-1554-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    3.60.20.10. 1 hit.
    InterProi IPR005854. Amd_phspho_trans.
    IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR029055. Ntn_hydrolases_N.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF13537. GATase_7. 1 hit.
    PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
    SUPFAMi SSF53271. SSF53271. 1 hit.
    SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01134. purF. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NTImported.

    Entry informationi

    Entry nameiA0Q1J3_CLONN
    AccessioniPrimary (citable) accession number: A0Q1J3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3