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A0Q1J2

- PUR5_CLONN

UniProt

A0Q1J2 - PUR5_CLONN

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, NT01CX_2421
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNOV386415:GH98-1553-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:NT01CX_2421
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000046434Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_2421.

Structurei

3D structure databases

ProteinModelPortaliA0Q1J2.
SMRiA0Q1J2. Positions 16-329.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A0Q1J2-1 [UniParc]FASTAAdd to Basket

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MATYKDAGVN IEEGYKAVSL MKNYAAKTFT KGVINDLGSF AGMFELSGYK    50
TPVLVSGTDG VGTKLKIAFD MKKYDTVGID CVAMCVNDIL CHGAKPLFFL 100
DYIACGKLEA ENAADLVRGV SDGCIDAGCS LIGGETAEMP GFYKEGEYDV 150
AGFCVGVVEK DEIIDGSKIE NGDVLIGIES TGIHSNGYSL VRKLIKDFNE 200
DFNGEKIGNV LLTPTKIYVK TVLELIKKYN IHGMAHITGG GFYENIPRMF 250
KGDFTAVINK GSFKVPEIFN HIMSLGVEEE HMYNTFNMGI GYVLCVKEED 300
AENIIRYIEK MGSKAYKIGH VEAGGHGVCL K 331
Length:331
Mass (Da):35,991
Last modified:January 9, 2007 - v1
Checksum:i52A4484F089BD5E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61544.1.
RefSeqiYP_878494.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK61544; ABK61544; NT01CX_2421.
GeneIDi4540669.
KEGGicno:NT01CX_2421.
PATRICi19480508. VBICloNov112828_1524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61544.1 .
RefSeqi YP_878494.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0Q1J2.
SMRi A0Q1J2. Positions 16-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_2421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK61544 ; ABK61544 ; NT01CX_2421 .
GeneIDi 4540669.
KEGGi cno:NT01CX_2421.
PATRICi 19480508. VBICloNov112828_1524.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CNOV386415:GH98-1553-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiPUR5_CLONN
AccessioniPrimary (citable) accession number: A0Q1J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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