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A0Q1J0

- PUR9_CLONN

UniProt

A0Q1J0 - PUR9_CLONN

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, NT01CX_2419
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCNOV386415:GH98-1551-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:NT01CX_2419
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018879Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_2419.

Structurei

3D structure databases

ProteinModelPortaliA0Q1J0.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0Q1J0-1 [UniParc]FASTAAdd to Basket

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MLKRALISVF NKEGIVDFAK FLVNKGVEII STGGTYKHLK ENNIPVTEVN    50
EVTGFDEILD GRVKTLHPAI HGGILAIRDN KEHMSIIENK GIKPIDMVVV 100
NLYPFFEKVK EDLEFQEKIE FIDIGGPTMI RAAAKNFKDV VVLTDTKDYS 150
DVMDQIEKNN EVNYDTRKRL AGKVFNLMAS YDAAISNFLL EDTEYPENLA 200
LSYTKSMDLR YGENSHQSAA CYTANNGKGI MNNIEILNGK QLSYNNIKDM 250
DIAWKVVWEF DDIACCGLKH NTPCGVALGE NVHDAYLKAY SCDPVSIFGG 300
IVAFNRKVDK KTAEEMVKIF LEIVIAPDFD SDALEVLKTK KNLRVIKCNT 350
KPEDNFNIAK VDGAILVQSE DKLFAEKMEV VTDKKPTEEE LKELTFAMKV 400
CKYTKSNAIV VSKGCVAVGI GGGQVNRIWA AEEALERGEG ATVLASDAFF 450
PFDDVVKTAA KHGIKAIIQP GGSIRDKDSI KACNENDISM VFTGIRHFKH 500
Length:500
Mass (Da):55,650
Last modified:January 9, 2007 - v1
Checksum:iFCF54E3C946C5F3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61189.1.
RefSeqiYP_878492.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK61189; ABK61189; NT01CX_2419.
GeneIDi4540229.
KEGGicno:NT01CX_2419.
PATRICi19480504. VBICloNov112828_1522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61189.1 .
RefSeqi YP_878492.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0Q1J0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_2419.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK61189 ; ABK61189 ; NT01CX_2419 .
GeneIDi 4540229.
KEGGi cno:NT01CX_2419.
PATRICi 19480504. VBICloNov112828_1522.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CNOV386415:GH98-1551-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiPUR9_CLONN
AccessioniPrimary (citable) accession number: A0Q1J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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