Reviewed, UniProtKB/Swiss-Prot A0Q1F0 (ARGC_CLONN)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	NT01CX_2379

Organism

Clostridium novyi (strain NT) [Complete proteome] [HAMAP]

Taxonomic identifier

386415 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000010989
Sites
	Active site	151	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0Q1F0-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: C342029CEDF443DD	FASTA	345	39,158
	10 20 30 40 50 60 MIKVGIIGST GYIGQQLVWL LKIHPNVEIV FLSSYNYAGY SFNSVYNNYK GFVETTCINI 70 80 90 100 110 120 KEVKTRLKDV DIVFMALPHG KSFEMVKYSL NLGIKVIDLS GDFRLKDSKE YEKWYKIEHP 130 140 150 160 170 180 LKEVLKYSVY GLPELFRKDI KKASLICNPG CYATASILAL APLIKLDLVE KGSIIVDAKS 190 200 210 220 230 240 GVSGAGRALK TQSLYCECNE TMKAYGIGNH RHTPEIEQEL SRFCKEDIKL TFTPHLVPIN 250 260 270 280 290 300 RGIFATCYAT LKKDLNKVQL EEAYEKFYEN DYFIKVMKEL VEVKWIKNSN FCNMNVNIDE 310 320 330 340 RTNKVIVSSV IDNLMKGAAS QAVQNMNILF GIDEKTGLNI PSMMI

References

[1]

"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT." Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S. Nat. Biotechnol. 24:1573-1580(2006) [PubMed: 17115055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000382 Genomic DNA. Translation: ABK61967.1.
RefSeq	YP_878452.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4540066.
GenomeReviews	Gene locus NT01CX_2379 in contig CP000382_GR.
KEGG	cno:NT01CX_2379.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A0Q1F0. VCRIAVH.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_CLONN

Accession

Primary (citable) accession number: A0Q1F0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)