A0Q171 (A0Q171_CLONN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel HAMAP MF_00115

Gene names

Name:	mscL HAMAP MF_00115 EMBL ABK61813.1
Ordered Locus Names:	NT01CX_2300

Organism

Clostridium novyi (strain NT) [Complete proteome] [HAMAP]

Taxonomic identifier

386415 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115 SAAS SAAS001185
Subunit structure	Homopentamer By similarity. HAMAP MF_00115 SAAS SAAS001185
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family. HAMAP MF_00115

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane HAMAP MF_00115 SAAS SAAS001185 Membrane
Domain	Transmembrane Transmembrane helix HAMAP MF_00115 SAAS SAAS001185
Molecular function	Ionic channel HAMAP MF_00115 SAAS SAAS001185
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Transmembrane	11 – 31	21	Helical; By similarity HAMAP MF_00115
	Transmembrane	33 – 53	21	Helical; By similarity HAMAP MF_00115
	Transmembrane	80 – 100	21	Helical; By similarity HAMAP MF_00115

Sequences

	Sequence		Length	Mass (Da)
	A0Q171 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 623396BE0BE1C822	FASTA	138	15,432
	10 20 30 40 50 60 MKKTIKEFKE FAMKGNVLDL AVGVVIGGAF GKIVSSLVKD VIMPIIGLIT GGINFTYLKI 70 80 90 100 110 120 TLKHGIGNKP PITLNIGNFI QNVVDFIIIA FSIFMFIKLI SKLQIKKVEE EKEKEEETPS 130 DEVVLLQEIR DLLKKDNK

References

[1]

"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT." Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S. Nat. Biotechnol. 24:1573-1580(2006) [PubMed: 17115055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000382 Genomic DNA. Translation: ABK61813.1.
RefSeq	YP_878373.1. NC_008593.1.
3D structure databases
ProteinModelPortal	A0Q171.
ModBase	Search...
Protein-protein interaction databases
STRING	A0Q171.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4540798.
GenomeReviews	Gene locus NT01CX_2300 in contig CP000382_GR.
KEGG	cno:NT01CX_2300.
PATRIC	19480268. VBICloNov112828_1404.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1970.
HOGENOM	HBG727604.
OMA	VIDFVIV.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0Q171_CLONN

Accession

Primary (citable) accession number: A0Q171

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)