A0Q140 (URK_CLONN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uridine kinase
EC=2.7.1.48

Alternative name(s):
Cytidine monophosphokinase
Uridine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	NT01CX_2269

Organism

Clostridium novyi (strain NT) [Complete proteome] [HAMAP]

Taxonomic identifier

386415 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium novyi

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP-Rule MF_00551 ATP + cytidine = ADP + CMP. HAMAP-Rule MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP-Rule MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP-Rule MF_00551
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	CTP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway UMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Uridine kinase HAMAP-Rule MF_00551		PRO_1000200512
Regions
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A0Q140 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: FE54519BBBA38E99	FASTA	208	23,908
	10 20 30 40 50 60 MMRPILIGIT GGTGSGKSTV ANEIYESFKD DCIAIIEQDS YYKDQSHLTF EDRIKTNYDH 70 80 90 100 110 120 PNAFDTELLV EHLKELSKGN TINKPIYDFK EHTRKKEVVE VKAKDIIIVE GIMILQDVEL 130 140 150 160 170 180 RNLLDIKIYV DTDDDVRIIR RILRDIKERG RTIDSVVDQY LGVVKPMHSQ FIEPTKKYAD 190 200 IIIPEGGQNK VAIDIMVSKI KQILSENK

References

[1]

"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT." Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S. Nat. Biotechnol. 24:1573-1580(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000382 Genomic DNA. Translation: ABK61121.1.
RefSeq	YP_878342.1. NC_008593.1.
3D structure databases
ProteinModelPortal	A0Q140.
ModBase	Search...
Protein-protein interaction databases
STRING	386415.NT01CX_2269.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK61121; ABK61121; NT01CX_2269.
GeneID	4541853.
KEGG	cno:NT01CX_2269.
PATRIC	19480204. VBICloNov112828_1372.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0572.
HOGENOM	HOG000262756.
KO	K00876.
OMA	DICFMRR.
ProtClustDB	PRK05480.
Enzyme and pathway databases
BioCyc	CNOV386415:GH98-1480-MONOMER.
UniPathway	UPA00574; UER00637. UPA00579; UER00640.
Family and domain databases
HAMAP	MF_00551. Uridine_kinase.
InterPro	IPR006083. PRK/URK. IPR000764. Uridine_kinase. [Graphical view]
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_CLONN

Accession

Primary (citable) accession number: A0Q140

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program