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A0Q0Z5

- ACKA_CLONN

UniProt

A0Q0Z5 - ACKA_CLONN

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Protein

Acetate kinase

Gene
ackA, NT01CX_2224
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction By similarity.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+. Can also accept Mn2+ By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Magnesium By similarity
Binding sitei14 – 141ATP By similarity
Binding sitei90 – 901Substrate By similarity
Active sitei147 – 1471Proton donor/acceptor By similarity
Sitei179 – 1791Transition state stabilizer By similarity
Sitei240 – 2401Transition state stabilizer By similarity
Metal bindingi383 – 3831Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi207 – 2115ATP By similarity
Nucleotide bindingi282 – 2843ATP By similarity
Nucleotide bindingi330 – 3345ATP By similarity

GO - Molecular functioni

  1. acetate kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  2. organic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNOV386415:GH98-1356-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinase (EC:2.7.2.1)
Alternative name(s):
Acetokinase
Gene namesi
Name:ackA
Ordered Locus Names:NT01CX_2224
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Acetate kinaseUniRule annotationPRO_1000002224Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi386415.NT01CX_2224.

Structurei

3D structure databases

ProteinModelPortaliA0Q0Z5.
SMRiA0Q0Z5. Positions 1-396.

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288398.
KOiK00925.
OMAiKYVTQRA.
OrthoDBiEOG69975F.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0Q0Z5-1 [UniParc]FASTAAdd to Basket

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MKILVINCGS SSLKYQLIDM TSEQPIAQGL VERIGIEGSV LTHKVNGKKY    50
KIEEEMKDHK KAIELVLNAL VNEEYGVIKN MEEISAVGHR VVHGGEKYAE 100
SVLIDSEVME ALEDFVKLAP LHNPPNIIGI NACKELMSST PMVAVFDTAF 150
HQTLPDYAYM YSLPYDLYEK HGIRKYGFHG TSHKYVSAMA AKVLGKNIED 200
LKLITCHLGN GSSLAAVKNG KCVDTSMGFT PLAGLTMGTR CGDIDPAIVT 250
FLIKELNYSV DEVNKIMNKE SGVLGISGIS SDFRDILKAA SEGNERAELA 300
LNIFKNKVIQ YIGAYTAVMG GVDAIIFTAG VGENSEPIRK RIISDLGFLG 350
IKLDEEKNKV MGETETISTE DSKVKVLAIP TNEELMIARD TKEIVEKNNI 400
K 401
Length:401
Mass (Da):43,982
Last modified:January 9, 2007 - v1
Checksum:iBADD5534819CF006
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK60556.1.
RefSeqiYP_878297.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK60556; ABK60556; NT01CX_2224.
GeneIDi4541780.
KEGGicno:NT01CX_2224.
PATRICi19480116. VBICloNov112828_1328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK60556.1 .
RefSeqi YP_878297.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0Q0Z5.
SMRi A0Q0Z5. Positions 1-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_2224.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK60556 ; ABK60556 ; NT01CX_2224 .
GeneIDi 4541780.
KEGGi cno:NT01CX_2224.
PATRICi 19480116. VBICloNov112828_1328.

Phylogenomic databases

eggNOGi COG0282.
HOGENOMi HOG000288398.
KOi K00925.
OMAi KYVTQRA.
OrthoDBi EOG69975F.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00458 .
BioCyci CNOV386415:GH98-1356-MONOMER.

Family and domain databases

HAMAPi MF_00020. Acetate_kinase.
InterProi IPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view ]
PANTHERi PTHR21060. PTHR21060. 1 hit.
Pfami PF00871. Acetate_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSi PR00471. ACETATEKNASE.
TIGRFAMsi TIGR00016. ackA. 1 hit.
PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiACKA_CLONN
AccessioniPrimary (citable) accession number: A0Q0Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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