Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A0Q0Z5

- ACKA_CLONN

UniProt

A0Q0Z5 - ACKA_CLONN

Protein

Acetate kinase

Gene

ackA

Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

    Catalytic activityi

    ATP + acetate = ADP + acetyl phosphate.UniRule annotation

    Cofactori

    Mg2+. Can also accept Mn2+.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71MagnesiumUniRule annotation
    Binding sitei14 – 141ATPUniRule annotation
    Binding sitei90 – 901SubstrateUniRule annotation
    Active sitei147 – 1471Proton donor/acceptorUniRule annotation
    Sitei179 – 1791Transition state stabilizerUniRule annotation
    Sitei240 – 2401Transition state stabilizerUniRule annotation
    Metal bindingi383 – 3831MagnesiumUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi207 – 2115ATPUniRule annotation
    Nucleotide bindingi282 – 2843ATPUniRule annotation
    Nucleotide bindingi330 – 3345ATPUniRule annotation

    GO - Molecular functioni

    1. acetate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
    2. organic acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCNOV386415:GH98-1356-MONOMER.
    UniPathwayiUPA00340; UER00458.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
    Alternative name(s):
    AcetokinaseUniRule annotation
    Gene namesi
    Name:ackAUniRule annotation
    Ordered Locus Names:NT01CX_2224
    OrganismiClostridium novyi (strain NT)
    Taxonomic identifieri386415 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000008220: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Acetate kinasePRO_1000002224Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi386415.NT01CX_2224.

    Structurei

    3D structure databases

    ProteinModelPortaliA0Q0Z5.
    SMRiA0Q0Z5. Positions 1-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetokinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0282.
    HOGENOMiHOG000288398.
    KOiK00925.
    OMAiKYVTQRA.
    OrthoDBiEOG69975F.

    Family and domain databases

    HAMAPiMF_00020. Acetate_kinase.
    InterProiIPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view]
    PANTHERiPTHR21060. PTHR21060. 1 hit.
    PfamiPF00871. Acetate_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSiPR00471. ACETATEKNASE.
    TIGRFAMsiTIGR00016. ackA. 1 hit.
    PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
    PS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0Q0Z5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILVINCGS SSLKYQLIDM TSEQPIAQGL VERIGIEGSV LTHKVNGKKY    50
    KIEEEMKDHK KAIELVLNAL VNEEYGVIKN MEEISAVGHR VVHGGEKYAE 100
    SVLIDSEVME ALEDFVKLAP LHNPPNIIGI NACKELMSST PMVAVFDTAF 150
    HQTLPDYAYM YSLPYDLYEK HGIRKYGFHG TSHKYVSAMA AKVLGKNIED 200
    LKLITCHLGN GSSLAAVKNG KCVDTSMGFT PLAGLTMGTR CGDIDPAIVT 250
    FLIKELNYSV DEVNKIMNKE SGVLGISGIS SDFRDILKAA SEGNERAELA 300
    LNIFKNKVIQ YIGAYTAVMG GVDAIIFTAG VGENSEPIRK RIISDLGFLG 350
    IKLDEEKNKV MGETETISTE DSKVKVLAIP TNEELMIARD TKEIVEKNNI 400
    K 401
    Length:401
    Mass (Da):43,982
    Last modified:January 9, 2007 - v1
    Checksum:iBADD5534819CF006
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK60556.1.
    RefSeqiYP_878297.1. NC_008593.1.

    Genome annotation databases

    EnsemblBacteriaiABK60556; ABK60556; NT01CX_2224.
    GeneIDi4541780.
    KEGGicno:NT01CX_2224.
    PATRICi19480116. VBICloNov112828_1328.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK60556.1 .
    RefSeqi YP_878297.1. NC_008593.1.

    3D structure databases

    ProteinModelPortali A0Q0Z5.
    SMRi A0Q0Z5. Positions 1-396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386415.NT01CX_2224.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK60556 ; ABK60556 ; NT01CX_2224 .
    GeneIDi 4541780.
    KEGGi cno:NT01CX_2224.
    PATRICi 19480116. VBICloNov112828_1328.

    Phylogenomic databases

    eggNOGi COG0282.
    HOGENOMi HOG000288398.
    KOi K00925.
    OMAi KYVTQRA.
    OrthoDBi EOG69975F.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00458 .
    BioCyci CNOV386415:GH98-1356-MONOMER.

    Family and domain databases

    HAMAPi MF_00020. Acetate_kinase.
    InterProi IPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR21060. PTHR21060. 1 hit.
    Pfami PF00871. Acetate_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSi PR00471. ACETATEKNASE.
    TIGRFAMsi TIGR00016. ackA. 1 hit.
    PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
    PS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NT.

    Entry informationi

    Entry nameiACKA_CLONN
    AccessioniPrimary (citable) accession number: A0Q0Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3