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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Clostridium novyi (strain NT)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCNOV386415:G1G6M-1059-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:NT01CX_1939
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000008220 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei48 – 68HelicalUniRule annotationAdd BLAST21
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21
Transmembranei106 – 126HelicalUniRule annotationAdd BLAST21
Transmembranei147 – 169HelicalUniRule annotationAdd BLAST23
Transmembranei174 – 194HelicalUniRule annotationAdd BLAST21
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei223 – 243HelicalUniRule annotationAdd BLAST21
Transmembranei246 – 266HelicalUniRule annotationAdd BLAST21
Transmembranei298 – 318HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029631 – 325Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST325

Proteomic databases

PRIDEiA0Q060

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_1939

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0Q060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMIYSVLV AFVVSLIQGP ILIPLLHKFK FGQNIRSEGP ESHKKKSGTP
60 70 80 90 100
TMGGVIFIIS SVITVFVVSR HPSFETKLAI FAFVAFGIIG LIDDSLKIIH
110 120 130 140 150
KENEGLKAYQ KMILLLIVSS IIGFYAYNNP RIGSEIIVPF VHKTWNLGMF
160 170 180 190 200
YIPFIIFYFA ATTNAVNLTD GLDGLATSIT LLVMTFFAVV SYATGNYNLA
210 220 230 240 250
VFCSIVAGAL LGFLKYNAYP AQVFMGDTGS LALGGVVGAV AMMLKLPLIV
260 270 280 290 300
IIVGGIYLAE ALSVILQVGS FKLRGKRIFK MSPIHHHFEL SGWHETKIVS
310 320
IFSIITVILC LIGFLSLIKM NGFSL
Length:325
Mass (Da):35,499
Last modified:January 9, 2007 - v1
Checksum:i483F03A29D9CFC75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA Translation: ABK61653.1
RefSeqiWP_011722016.1, NC_008593.1

Genome annotation databases

EnsemblBacteriaiABK61653; ABK61653; NT01CX_1939
GeneIDi4541236
KEGGicno:NT01CX_1939
PATRICifig|386415.7.peg.1041

Entry informationi

Entry nameiMRAY_CLONN
AccessioniPrimary (citable) accession number: A0Q060
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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