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A0PZT1

- PBPA_CLONN

UniProt

A0PZT1 - PBPA_CLONN

Protein

Penicillin-binding protein 1A

Gene

pbpA

Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei431 – 4311Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. penicillin binding Source: InterPro
    3. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. regulation of cell shape Source: UniProtKB-KW
    3. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Hydrolase, Transferase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciCNOV386415:GH98-942-MONOMER.
    UniPathwayiUPA00219.

    Protein family/group databases

    CAZyiGT51. Glycosyltransferase Family 51.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Penicillin-binding protein 1A
    Short name:
    PBP1a
    Including the following 2 domains:
    Penicillin-insensitive transglycosylase (EC:2.4.2.-)
    Alternative name(s):
    Peptidoglycan TGase
    Penicillin-sensitive transpeptidase (EC:3.4.-.-)
    Alternative name(s):
    DD-transpeptidase
    Gene namesi
    Name:pbpA
    Ordered Locus Names:NT01CX_1810
    OrganismiClostridium novyi (strain NT)
    Taxonomic identifieri386415 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000008220: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Penicillin-binding protein 1APRO_0000321875Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi386415.NT01CX_1810.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PZT1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini50 – 863814ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni71 – 248178TransglycosylaseBy similarityAdd
    BLAST
    Regioni392 – 674283TranspeptidaseBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 258Poly-Lys

    Sequence similaritiesi

    In the N-terminal section; belongs to the glycosyltransferase 51 family.Curated
    In the C-terminal section; belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0744.
    HOGENOMiHOG000041137.
    KOiK05366.
    OMAiAFIADTM.
    OrthoDBiEOG6KDKQS.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR001264. Glyco_trans_51.
    IPR023346. Lysozyme-like_dom.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00912. Transgly. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    SSF56601. SSF56601. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    A0PZT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTENRDNKTS QSEKTTQKKK KKKFKAFKII LITFITLIVI SLVTAIGITL    50
    AIIKTSPDIN INEIIAASDA SKIYDDKGEL VDSIITSKKK ILVKYDEVPE 100
    NLINAFVSIE DERFFKHSGI DVKRIAGAFL IDMKNIVSGK PALQGASTIT 150
    QQLIKNTVFE THGNSLNDKL RRKVQEWYLA PKLEKEVGKK SIMEAYLNTI 200
    YLGGRAIGVG AAADQYFNVS IDKLDLVQCA FIAGLPQSPS VYYPYSRTSK 250
    KDPSKYINRT KTVLAKMKEN GYISQNEYIS ALAELDTSKS TVTNDESIQT 300
    LGQYTIHKPT NIDEKYNFEW FTRPAIERVK KDLKDIYNYS DDEIEKLLVN 350
    GNLKIYTTMN KDLQVSTQEI IDNDEKLNSL SSSKNNLVEP QASAVLTDYH 400
    TGEVKVIIGG RGTQPALAYN RATNAKVAAG SSIKPLTVYS AAIDSKLATA 450
    ATVLEDSPLP EAMSKKYSAP GTNWQPKNAN GVYSGYLGLR DALKNSVNVY 500
    AVKLEDKIGL NTGVKYGEKF GLTFDNVDKN SMAAIALGEL NRGTNTFTMA 550
    NAYGVFGNNG MYSNPRLYTK VLDRNGNVLL ETKTQATQVI SPEAAYIMYD 600
    LLKGPVKEGT ATRIQHTYHS DIPIAGKTGS STKFKNLWFC GLTPYYSGAV 650
    WIENKYGQSI YSSDAAALFG KIMNRAVENL PEKEIEMPEG IIKAEVDRVS 700
    GLLPTDLSYK DPRGSQVYTE LFIKGTVPTE QDNIHVSTKV NKYNGRVSGS 750
    YTPSFLTESK VFIKRQSDSE VPLDDDMYVL PDKDKKSSNK SKHNHNNDAK 800
    HDNTNNSEDA TNEASTEPSP NTDTVPEDST NNLDPTKNTE KKPSDKKNKK 850
    HVIKPIIRPK KHF 863
    Length:863
    Mass (Da):95,824
    Last modified:January 9, 2007 - v1
    Checksum:iA0250C35592BC539
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK60403.1.
    RefSeqiYP_877883.1. NC_008593.1.

    Genome annotation databases

    EnsemblBacteriaiABK60403; ABK60403; NT01CX_1810.
    GeneIDi4540909.
    KEGGicno:NT01CX_1810.
    PATRICi19479286. VBICloNov112828_0913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK60403.1 .
    RefSeqi YP_877883.1. NC_008593.1.

    3D structure databases

    ProteinModelPortali A0PZT1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386415.NT01CX_1810.

    Protein family/group databases

    CAZyi GT51. Glycosyltransferase Family 51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK60403 ; ABK60403 ; NT01CX_1810 .
    GeneIDi 4540909.
    KEGGi cno:NT01CX_1810.
    PATRICi 19479286. VBICloNov112828_0913.

    Phylogenomic databases

    eggNOGi COG0744.
    HOGENOMi HOG000041137.
    KOi K05366.
    OMAi AFIADTM.
    OrthoDBi EOG6KDKQS.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci CNOV386415:GH98-942-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR001264. Glyco_trans_51.
    IPR023346. Lysozyme-like_dom.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00912. Transgly. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    SSF56601. SSF56601. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NT.

    Entry informationi

    Entry nameiPBPA_CLONN
    AccessioniPrimary (citable) accession number: A0PZT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3