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A0PZT1

- PBPA_CLONN

UniProt

A0PZT1 - PBPA_CLONN

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Protein

Penicillin-binding protein 1A

Gene
pbpA, NT01CX_1810
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei431 – 4311Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. penicillin binding Source: InterPro
  3. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  2. regulation of cell shape Source: UniProtKB-KW
  3. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Hydrolase, Transferase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCNOV386415:GH98-942-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 1A
Short name:
PBP1a
Including the following 2 domains:
Penicillin-insensitive transglycosylase (EC:2.4.2.-)
Alternative name(s):
Peptidoglycan TGase
Penicillin-sensitive transpeptidase (EC:3.4.-.-)
Alternative name(s):
DD-transpeptidase
Gene namesi
Name:pbpA
Ordered Locus Names:NT01CX_1810
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei29 – 4921Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini50 – 863814Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Penicillin-binding protein 1APRO_0000321875Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_1810.

Structurei

3D structure databases

ProteinModelPortaliA0PZT1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni71 – 248178Transglycosylase By similarityAdd
BLAST
Regioni392 – 674283Transpeptidase By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 258Poly-Lys

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 51 family.
In the C-terminal section; belongs to the transpeptidase family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0744.
HOGENOMiHOG000041137.
KOiK05366.
OMAiAFIADTM.
OrthoDBiEOG6KDKQS.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.

Sequencei

Sequence statusi: Complete.

A0PZT1-1 [UniParc]FASTAAdd to Basket

« Hide

MTENRDNKTS QSEKTTQKKK KKKFKAFKII LITFITLIVI SLVTAIGITL    50
AIIKTSPDIN INEIIAASDA SKIYDDKGEL VDSIITSKKK ILVKYDEVPE 100
NLINAFVSIE DERFFKHSGI DVKRIAGAFL IDMKNIVSGK PALQGASTIT 150
QQLIKNTVFE THGNSLNDKL RRKVQEWYLA PKLEKEVGKK SIMEAYLNTI 200
YLGGRAIGVG AAADQYFNVS IDKLDLVQCA FIAGLPQSPS VYYPYSRTSK 250
KDPSKYINRT KTVLAKMKEN GYISQNEYIS ALAELDTSKS TVTNDESIQT 300
LGQYTIHKPT NIDEKYNFEW FTRPAIERVK KDLKDIYNYS DDEIEKLLVN 350
GNLKIYTTMN KDLQVSTQEI IDNDEKLNSL SSSKNNLVEP QASAVLTDYH 400
TGEVKVIIGG RGTQPALAYN RATNAKVAAG SSIKPLTVYS AAIDSKLATA 450
ATVLEDSPLP EAMSKKYSAP GTNWQPKNAN GVYSGYLGLR DALKNSVNVY 500
AVKLEDKIGL NTGVKYGEKF GLTFDNVDKN SMAAIALGEL NRGTNTFTMA 550
NAYGVFGNNG MYSNPRLYTK VLDRNGNVLL ETKTQATQVI SPEAAYIMYD 600
LLKGPVKEGT ATRIQHTYHS DIPIAGKTGS STKFKNLWFC GLTPYYSGAV 650
WIENKYGQSI YSSDAAALFG KIMNRAVENL PEKEIEMPEG IIKAEVDRVS 700
GLLPTDLSYK DPRGSQVYTE LFIKGTVPTE QDNIHVSTKV NKYNGRVSGS 750
YTPSFLTESK VFIKRQSDSE VPLDDDMYVL PDKDKKSSNK SKHNHNNDAK 800
HDNTNNSEDA TNEASTEPSP NTDTVPEDST NNLDPTKNTE KKPSDKKNKK 850
HVIKPIIRPK KHF 863
Length:863
Mass (Da):95,824
Last modified:January 9, 2007 - v1
Checksum:iA0250C35592BC539
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK60403.1.
RefSeqiYP_877883.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK60403; ABK60403; NT01CX_1810.
GeneIDi4540909.
KEGGicno:NT01CX_1810.
PATRICi19479286. VBICloNov112828_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK60403.1 .
RefSeqi YP_877883.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0PZT1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_1810.

Protein family/group databases

CAZyi GT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK60403 ; ABK60403 ; NT01CX_1810 .
GeneIDi 4540909.
KEGGi cno:NT01CX_1810.
PATRICi 19479286. VBICloNov112828_0913.

Phylogenomic databases

eggNOGi COG0744.
HOGENOMi HOG000041137.
KOi K05366.
OMAi AFIADTM.
OrthoDBi EOG6KDKQS.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CNOV386415:GH98-942-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiPBPA_CLONN
AccessioniPrimary (citable) accession number: A0PZT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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