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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Clostridium novyi (strain NT)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8SubstrateUniRule annotation1
Binding sitei12SubstrateUniRule annotation1
Active sitei60Proton donor/acceptorUniRule annotation1
Binding sitei87SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:NT01CX_1696
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000008220 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000178041 – 123Methylglyoxal synthaseAdd BLAST123

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_1696

Structurei

3D structure databases

ProteinModelPortaliA0PZH3
SMRiA0PZH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 123MGS-likeUniRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4
Regioni54 – 55Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
HOGENOMiHOG000283729
KOiK01734
OMAiRACDVHN
OrthoDBiPOG091H04UH

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR018148 Methylglyoxal_synth_AS
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit
PROSITEiView protein in PROSITE
PS01335 METHYLGLYOXAL_SYNTH, 1 hit
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

A0PZH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIALIAHDG KKDDMIDLVS RYKNVFEEHE LFATGTTGKL INEKTGLNVT
60 70 80 90 100
RFLSGPLGGD QQIGAKVAVG EMDMIIFLRD PLTAQPHEPD VSALLRICDV
110 120
HYIPLATNVG SAEVFIKALS VKR
Length:123
Mass (Da):13,476
Last modified:January 9, 2007 - v1
Checksum:i546603B14302A35B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA Translation: ABK60978.1
RefSeqiWP_011721782.1, NC_008593.1

Genome annotation databases

EnsemblBacteriaiABK60978; ABK60978; NT01CX_1696
GeneIDi4540189
KEGGicno:NT01CX_1696

Similar proteinsi

Entry informationi

Entry nameiMGSA_CLONN
AccessioniPrimary (citable) accession number: A0PZH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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