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A0PYK3

- SYL_CLONN

UniProt

A0PYK3 - SYL_CLONN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei575 – 5751ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCNOV386415:GH98-504-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:NT01CX_1372
    OrganismiClostridium novyi (strain NT)
    Taxonomic identifieri386415 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000008220: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 812812Leucine--tRNA ligasePRO_1000009328Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi386415.NT01CX_1372.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PYK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi572 – 5765"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0PYK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNYGTTVDE KWQKKWEESG LHNFDENAPG EKLYVLEMFS YPSAAKLHAG    50
    HWFNYGPTDS WARFKKMNGY NVFQPMGFDA FGLPAENFAI KTGIHPQDST 100
    MKNIENMEEQ LRSMGAMFNW DHEIITCLPD YYKWTQWVFL KLYEKGLAYR 150
    KNAPVNWCPS CNTVLANEQV LDGHCERCDS LVEKKALTQW FLKITDYADE 200
    LLEKLDGLDW PEKTKAMQKH WIGKSKGVEA TFKVENSDIT FDVFTTRVDT 250
    LNGVTYVVLA PENELVDSLT TEENKAAVEA YKIEAQKQSD IERQSSTREK 300
    TGVFTGSYAI NPINGNKVPI WVGDYVLATY GTGCVMAVPA HDERDYAFAT 350
    KYDLPIVRVI EGGDSLPFTE YGSLVNSGEF DGLYGEEAKE AIVKKLQEQK 400
    LGNWKVNYRL RDWLVSRQRY WGAPIPVVYC DKCGTVAVPE EQLPVELPYN 450
    IEFTPDGKSP LSKSEEFLHT TCPKCGGHAV RETDTLDTFV CSSWYYLRYV 500
    DNNNSEKAFD IDKVNKMLPV DKYVGGPEHA CMHLLYARFI TKALRDMGYL 550
    NFDEPFTSLT HQGLILGPDG LKMSKSKGNT IAPDDYIKEY GADVFRMYLM 600
    FGFAYSEGGA WSDDAIKSMS KFVDKVERIL ADSRTQMADS KNTKTTIEKA 650
    EKELNYTRHY AIQHVTEDTE KFQFNTAIAR IMEYTNSLSK YLNEENLNVE 700
    FLKEALTDYI KLLAPFAPHF SEEQWELLGN TSSVFTTSWP KFDPKALVKD 750
    EVEIAIQILG KIKARMNIAT NLTDEEIKEA ALNNETIKGL LEGKNIIKVI 800
    VVKGSLVNIV AK 812
    Length:812
    Mass (Da):92,378
    Last modified:January 9, 2007 - v1
    Checksum:iD95725B24357888A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK61363.1.
    RefSeqiYP_877455.1. NC_008593.1.

    Genome annotation databases

    EnsemblBacteriaiABK61363; ABK61363; NT01CX_1372.
    GeneIDi4541679.
    KEGGicno:NT01CX_1372.
    PATRICi19478402. VBICloNov112828_0480.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK61363.1 .
    RefSeqi YP_877455.1. NC_008593.1.

    3D structure databases

    ProteinModelPortali A0PYK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386415.NT01CX_1372.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK61363 ; ABK61363 ; NT01CX_1372 .
    GeneIDi 4541679.
    KEGGi cno:NT01CX_1372.
    PATRICi 19478402. VBICloNov112828_0480.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CNOV386415:GH98-504-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NT.

    Entry informationi

    Entry nameiSYL_CLONN
    AccessioniPrimary (citable) accession number: A0PYK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3