Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0PYK3

- SYL_CLONN

UniProt

A0PYK3 - SYL_CLONN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei575 – 5751ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNOV386415:GH98-504-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:NT01CX_1372
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812Leucine--tRNA ligasePRO_1000009328Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_1372.

Structurei

3D structure databases

ProteinModelPortaliA0PYK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi572 – 5765"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A0PYK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNYGTTVDE KWQKKWEESG LHNFDENAPG EKLYVLEMFS YPSAAKLHAG
60 70 80 90 100
HWFNYGPTDS WARFKKMNGY NVFQPMGFDA FGLPAENFAI KTGIHPQDST
110 120 130 140 150
MKNIENMEEQ LRSMGAMFNW DHEIITCLPD YYKWTQWVFL KLYEKGLAYR
160 170 180 190 200
KNAPVNWCPS CNTVLANEQV LDGHCERCDS LVEKKALTQW FLKITDYADE
210 220 230 240 250
LLEKLDGLDW PEKTKAMQKH WIGKSKGVEA TFKVENSDIT FDVFTTRVDT
260 270 280 290 300
LNGVTYVVLA PENELVDSLT TEENKAAVEA YKIEAQKQSD IERQSSTREK
310 320 330 340 350
TGVFTGSYAI NPINGNKVPI WVGDYVLATY GTGCVMAVPA HDERDYAFAT
360 370 380 390 400
KYDLPIVRVI EGGDSLPFTE YGSLVNSGEF DGLYGEEAKE AIVKKLQEQK
410 420 430 440 450
LGNWKVNYRL RDWLVSRQRY WGAPIPVVYC DKCGTVAVPE EQLPVELPYN
460 470 480 490 500
IEFTPDGKSP LSKSEEFLHT TCPKCGGHAV RETDTLDTFV CSSWYYLRYV
510 520 530 540 550
DNNNSEKAFD IDKVNKMLPV DKYVGGPEHA CMHLLYARFI TKALRDMGYL
560 570 580 590 600
NFDEPFTSLT HQGLILGPDG LKMSKSKGNT IAPDDYIKEY GADVFRMYLM
610 620 630 640 650
FGFAYSEGGA WSDDAIKSMS KFVDKVERIL ADSRTQMADS KNTKTTIEKA
660 670 680 690 700
EKELNYTRHY AIQHVTEDTE KFQFNTAIAR IMEYTNSLSK YLNEENLNVE
710 720 730 740 750
FLKEALTDYI KLLAPFAPHF SEEQWELLGN TSSVFTTSWP KFDPKALVKD
760 770 780 790 800
EVEIAIQILG KIKARMNIAT NLTDEEIKEA ALNNETIKGL LEGKNIIKVI
810
VVKGSLVNIV AK
Length:812
Mass (Da):92,378
Last modified:January 9, 2007 - v1
Checksum:iD95725B24357888A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61363.1.
RefSeqiYP_877455.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK61363; ABK61363; NT01CX_1372.
GeneIDi4541679.
KEGGicno:NT01CX_1372.
PATRICi19478402. VBICloNov112828_0480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61363.1 .
RefSeqi YP_877455.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0PYK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_1372.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK61363 ; ABK61363 ; NT01CX_1372 .
GeneIDi 4541679.
KEGGi cno:NT01CX_1372.
PATRICi 19478402. VBICloNov112828_0480.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CNOV386415:GH98-504-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiSYL_CLONN
AccessioniPrimary (citable) accession number: A0PYK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3