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A0PYK3

- SYL_CLONN

UniProt

A0PYK3 - SYL_CLONN

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Protein
Leucine--tRNA ligase
Gene
leuS, NT01CX_1372
Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei575 – 5751ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCNOV386415:GH98-504-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:NT01CX_1372
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008220: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812Leucine--tRNA ligaseUniRule annotation
PRO_1000009328Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi386415.NT01CX_1372.

Structurei

3D structure databases

ProteinModelPortaliA0PYK3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi572 – 5765"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A0PYK3-1 [UniParc]FASTAAdd to Basket

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MGNYGTTVDE KWQKKWEESG LHNFDENAPG EKLYVLEMFS YPSAAKLHAG    50
HWFNYGPTDS WARFKKMNGY NVFQPMGFDA FGLPAENFAI KTGIHPQDST 100
MKNIENMEEQ LRSMGAMFNW DHEIITCLPD YYKWTQWVFL KLYEKGLAYR 150
KNAPVNWCPS CNTVLANEQV LDGHCERCDS LVEKKALTQW FLKITDYADE 200
LLEKLDGLDW PEKTKAMQKH WIGKSKGVEA TFKVENSDIT FDVFTTRVDT 250
LNGVTYVVLA PENELVDSLT TEENKAAVEA YKIEAQKQSD IERQSSTREK 300
TGVFTGSYAI NPINGNKVPI WVGDYVLATY GTGCVMAVPA HDERDYAFAT 350
KYDLPIVRVI EGGDSLPFTE YGSLVNSGEF DGLYGEEAKE AIVKKLQEQK 400
LGNWKVNYRL RDWLVSRQRY WGAPIPVVYC DKCGTVAVPE EQLPVELPYN 450
IEFTPDGKSP LSKSEEFLHT TCPKCGGHAV RETDTLDTFV CSSWYYLRYV 500
DNNNSEKAFD IDKVNKMLPV DKYVGGPEHA CMHLLYARFI TKALRDMGYL 550
NFDEPFTSLT HQGLILGPDG LKMSKSKGNT IAPDDYIKEY GADVFRMYLM 600
FGFAYSEGGA WSDDAIKSMS KFVDKVERIL ADSRTQMADS KNTKTTIEKA 650
EKELNYTRHY AIQHVTEDTE KFQFNTAIAR IMEYTNSLSK YLNEENLNVE 700
FLKEALTDYI KLLAPFAPHF SEEQWELLGN TSSVFTTSWP KFDPKALVKD 750
EVEIAIQILG KIKARMNIAT NLTDEEIKEA ALNNETIKGL LEGKNIIKVI 800
VVKGSLVNIV AK 812
Length:812
Mass (Da):92,378
Last modified:January 9, 2007 - v1
Checksum:iD95725B24357888A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61363.1.
RefSeqiYP_877455.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK61363; ABK61363; NT01CX_1372.
GeneIDi4541679.
KEGGicno:NT01CX_1372.
PATRICi19478402. VBICloNov112828_0480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000382 Genomic DNA. Translation: ABK61363.1 .
RefSeqi YP_877455.1. NC_008593.1.

3D structure databases

ProteinModelPortali A0PYK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 386415.NT01CX_1372.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK61363 ; ABK61363 ; NT01CX_1372 .
GeneIDi 4541679.
KEGGi cno:NT01CX_1372.
PATRICi 19478402. VBICloNov112828_0480.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CNOV386415:GH98-504-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NT.

Entry informationi

Entry nameiSYL_CLONN
AccessioniPrimary (citable) accession number: A0PYK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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