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Reviewed, UniProtKB/Swiss-Prot A0PYE7 (AROD_CLONN)

Last modified November 3, 2009. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-dehydroquinate dehydratase
      Short name=3-dehydroquinase
    EC=4.2.1.10
Alternative name(s):
    Type I DHQase
Gene names
Name: aroD
Ordered Locus Names: NT01CX_1316
OrganismClostridium novyi (strain NT) [Complete proteome] [HAMAP]
Taxonomic identifier386415 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2532533-dehydroquinate dehydratase HAMAP MF_00214
PRO_1000043161

Sites

Active site1431Proton acceptor By similarity
Active site1701Schiff-base intermediate with substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A0PYE7-1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 9108D5328607117D

FASTA25328,470
        10         20         30         40         50         60 
MKTVNIRGVI LGEGIPKVCT PLVGRSLKEL REEINLLKDI DCDLVEFRAD FFEHVENIQK 

        70         80         90        100        110        120 
VKEVLLEIRE ALKEKPILFT FRSAKEGGER EVESEFYCKL NKEIIKTKLI DAIDIELFNE 

       130        140        150        160        170        180 
EESILELIKI AHDEDVKVVM SNHDFHKTPP KEEMISRLVK MQELGADVTK IAVMPKGSSD 

       190        200        210        220        230        240 
VLTLLEATND MKIKYAKTPF ITMSMKGVGM ISRISGEVFG SAVTFGASKK ASAPGQLQVK 

       250 
ELKEILNVVH NVL 

« Hide

References

[1]"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT."
Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S.
Nat. Biotechnol. 24:1573-1580(2006) [PubMed: 17115055] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000382 Genomic DNA. Translation: ABK61917.1.
RefSeqYP_877399.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA0PYE7.

Genome annotation databases

GeneID4541218.
GenomeReviewsGene locus NT01CX_1316 in contig CP000382_GR.
KEGGcno:NT01CX_1316.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAMSNHDFD.

Family and domain databases

HAMAPMF_00214.
[Tree]
InterProIPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
ProDomPD005337. DHquinase_I. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01093. aroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROD_CLONN
AccessionPrimary (citable) accession number: A0PYE7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents