A0PXZ6 (GLMM_CLONN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	NT01CX_1165

Organism

Clostridium novyi (strain NT) [Complete proteome] [HAMAP]

Taxonomic identifier

386415 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_0000301301
Sites
	Active site	100	1	Phosphoserine intermediate By similarity
	Metal binding	100	1	Magnesium; via phosphate group By similarity
	Metal binding	240	1	Magnesium By similarity
	Metal binding	242	1	Magnesium By similarity
	Metal binding	244	1	Magnesium By similarity
Amino acid modifications
	Modified residue	100	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0PXZ6 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 351278F462C42564	FASTA	449	48,486
	10 20 30 40 50 60 MGRLFGTDGV RGVANTELTA DLAFKLGRAG AFVLTEGTHK PKILVGMDTR ISGDMLEAAL 70 80 90 100 110 120 VAGILSVGAE AICVGVVPTP AIAYLTRKYK ADAGVVISAS HNPVEYNGIK FFNKNGYKLK 130 140 150 160 170 180 DELEDRIQSI IENNFEGVPS PTGENLGRKI TCESAIDDYV EFAKSTIDVD LKGLKIALDC 190 200 210 220 230 240 ANGASYKTSV ETFRELGAEV VVINNDPDGV NINKNCGSTH PEELMDYVVK QGCDLGLAFD 250 260 270 280 290 300 GDADRCLAVD EKGNLIDGDF IMTICGKHLK DQGKLKDNMV VVTVMSNLGL SLAFDKENIS 310 320 330 340 350 360 TIKTKVGDRY VLEEMVKDGY KLGGEQSGHI IFLDYNTTGD GLVTGLQIAS IVKETGKTLS 370 380 390 400 410 420 ELASIMTKLP QVLVNAKVPN NMKDIHEKDA EIAEEIKKIE EKLNGCGRVL IRPSGTEPLV 430 440 RVMLEGENQE ELDKIAHALA KMIEEKANA

References

[1]

"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT." Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S. Nat. Biotechnol. 24:1573-1580(2006) [PubMed: 17115055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000382 Genomic DNA. Translation: ABK61023.1.
RefSeq	YP_877248.1. NC_008593.1.
3D structure databases
ProteinModelPortal	A0PXZ6.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PXZ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4541926.
GenomeReviews	Gene locus NT01CX_1165 in contig CP000382_GR.
KEGG	cno:NT01CX_1165.
PATRIC	19477994. VBICloNov112828_0276.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HBG644964.
OMA	LGLDIAC.
ProtClustDB	PRK14316.
Enzyme and pathway databases
BioCyc	CNOV386415:NT01CX_1165-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_CLONN

Accession

Primary (citable) accession number: A0PXZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program