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A0PXW6 (A0PXW6_CLONN) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein translocase subunit SecY RuleBase RU000537 HAMAP-Rule MF_01465
Gene names
Name:secY HAMAP-Rule MF_01465
Ordered Locus Names:NT01CX_1135
OrganismClostridium novyi (strain NT) [Complete proteome] [HAMAP] EMBL ABK61359.1
Taxonomic identifier386415 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium ›

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity. RuleBase RU000537 HAMAP-Rule MF_01465

Subunit structure

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity. HAMAP-Rule MF_01465

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01465.

Membrane; Multi-pass membrane protein By similarity RuleBase RU003484.

Sequence similarities

Belongs to the SecY/SEC61-alpha family. HAMAP-Rule MF_01465 RuleBase RU004349

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane17 – 3721Helical; By similarity HAMAP-Rule MF_01465
Transmembrane69 – 8921Helical; By similarity HAMAP-Rule MF_01465
Transmembrane114 – 13118Helical; By similarity HAMAP-Rule MF_01465
Transmembrane143 – 16321Helical; By similarity HAMAP-Rule MF_01465
Transmembrane165 – 18521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane208 – 22821Helical; By similarity HAMAP-Rule MF_01465
Transmembrane262 – 28221Helical; By similarity HAMAP-Rule MF_01465
Transmembrane306 – 32621Helical; By similarity HAMAP-Rule MF_01465
Transmembrane364 – 38421Helical; By similarity HAMAP-Rule MF_01465
Transmembrane386 – 40621Helical; By similarity HAMAP-Rule MF_01465

Sequences

Sequence LengthMass (Da)Tools
A0PXW6 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: AA86B81CC0F7DFBC

FASTA42446,893
        10         20         30         40         50         60 
MSTLRNAWKV PELRKRILFT LFMVAIIRMG NHIPVPGIDT GALANMTKAG TLFSFYDLMS 

        70         80         90        100        110        120 
GGALSNFSIF AMGVIPYINS SIIFQLLTIA IPSLEQLSKE GEEGRKKIQK YTRYAAILLG 

       130        140        150        160        170        180 
ALQSFGTYAL IRNYGAATNI GKFDIFLMVL TLTTASTFLM WLGDQITVKG IGNGISLIIF 

       190        200        210        220        230        240 
VNIISRLPEK VLKINSLQQN QTVSIVQVIF LIVFVLLMFT GVVIATLAER RIPIQYAAKN 

       250        260        270        280        290        300 
SGGRMLKGQS THIPINMNSS AIIAIIFAMS VMQFPATIGS FWPQSAFYKF VTASKYSVFR 

       310        320        330        340        350        360 
MNSWPYAIIT AILVIFFTWF YTEVTFKPDE MAENIHKSAG FIPGVRPGEA TARFIEKVLV 

       370        380        390        400        410        420 
RVSILGGIFA TFIALVPMIF ESVGAFKGIS LGGTALLIEV GVALDFMRVL ESQLVMRHYK 


GFLK

« Hide

References

[1]"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT."
Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S.
Nat. Biotechnol. 24:1573-1580(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000382 Genomic DNA. Translation: ABK61359.1.
RefSeqYP_877218.1. NC_008593.1.

3D structure databases

ProteinModelPortalA0PXW6.
ModBaseSearch...

Protein-protein interaction databases

STRING386415.NT01CX_1135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK61359; ABK61359; NT01CX_1135.
GeneID4541675.
KEGGcno:NT01CX_1135.
PATRIC19477932. VBICloNov112828_0245.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0201.
HOGENOMHOG000080586.
KOK03076.
OMAFIMWLGE.
ProtClustDBPRK09204.

Enzyme and pathway databases

BioCycCNOV386415:GH98-356-MONOMER.

Family and domain databases

Gene3D1.10.3370.10. 1 hit.
HAMAPMF_01465. SecY.
InterProIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERPTHR10906. PTHR10906. 1 hit.
PfamPF00344. SecY. 1 hit.
[Graphical view]
PIRSFPIRSF004557. SecY. 1 hit.
SUPFAMSSF103491. SecY. 1 hit.
TIGRFAMsTIGR00967. 3a0501s007. 1 hit.
PROSITEPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0PXW6_CLONN
AccessionPrimary (citable) accession number: A0PXW6
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info