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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Clostridium novyi (strain NT)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciCNOV386415:GH98-239-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:NT01CX_1107
OrganismiClostridium novyi (strain NT)
Taxonomic identifieri386415 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000008220 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12411241DNA-directed RNA polymerase subunit betaPRO_0000300301Add
BLAST

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi386415.NT01CX_1107.

Structurei

3D structure databases

ProteinModelPortaliA0PXT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PXT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHPIQIGKR TRMSFSKVKE MCPMPNLIEV QLNSYDWFWK EGLNEVFDDV
60 70 80 90 100
NPIQDYTGNL ILEFIDYNLD KDAIKYSVEE CKERDATYAA PLKVKVRLLN
110 120 130 140 150
KETGEVKEQE VFMGDFPLMT QQGTFVINGA ERVIVSQLVR SPGAYYGYDV
160 170 180 190 200
DKTGKKLFSS TVIPNRGAWL EYETDSNDII YVRIDKTRKL PISILIRALG
210 220 230 240 250
LGSDAEIVDW FGEEERLKAT IEKDNTKTRE EALLEIYKRL RPGEPPTVDS
260 270 280 290 300
ALSLINSLFF DAKRYDLSRV GRYKFNKKLA IYIRLLNQVA AEDVVNPFTG
310 320 330 340 350
EIIVQKGETI DREKALEIQN CAINAVNIQV EDKVIKVIGN NFVDIHKFID
360 370 380 390 400
FDISDLKIKE HVHYPTLKNI LDNYTDEKSI KEEIKKNIHE LIPKHIVVDD
410 420 430 440 450
IYATISYELG LPYEIGTIDD IDHLGNRRLR SVGELLQNQF RIGLSRMERV
460 470 480 490 500
VKERMTIQDQ EVITPQALIN IRPVAAAIKE FFGSSQLSQF MDQTNPLSEL
510 520 530 540 550
THKRRLSALG PGGLSRERAG FEVRDVHHSH YGRMCPIETP EGPNIGLINS
560 570 580 590 600
LACYAKVNEY GFIETPYRLV DKKEARVTDE IVYLTADEED HYLVAQAKEP
610 620 630 640 650
LDENGCFIDE KITVRDLEDV IVVSKDQVDL MDVSPSQIVS VATAMIPFLE
660 670 680 690 700
NDDASRALMG SNMQRQAVPL LKPAAPIVGT GIEYKAAVDS GVLPKAEHDG
710 720 730 740 750
VIEYVSSTEV RIRRDSDGGL DKHKLLKYKR SNQGTCINQR PIVSKGEKVK
760 770 780 790 800
AGDVLADGPS TDFGEIALGQ NIRMGFITWE GYNYEDAMLV SEQLVRDDIF
810 820 830 840 850
TSIHIEEYES EARDTKLGPE EITRDIPNVG EDALKNIDER GIVRIGAEVR
860 870 880 890 900
SGDILVGKVT PKGETELTAE ERLLRAIFGE KAREVRDTSL RVPHGEAGII
910 920 930 940 950
VDVKVFTREN GDELPPGVNE LVRCYIAQKR KISVGDKMAG RHGNKGVISR
960 970 980 990 1000
ILPEEDMPFL PDGRPLQICL NPLGVPSRMN IGQVLEVHLG WAAGEMGWHI
1010 1020 1030 1040 1050
ATPVFNGAFE DEIVELLQEA GYSEDGKTVL YDGRTGEPFD NRVTVGYMYI
1060 1070 1080 1090 1100
LKLHHLVDDK IHARSTGPYS LVTQQPLGGK AQFGGQRFGE MEVWALEAYG
1110 1120 1130 1140 1150
AAHTLQEVLT VKSDDVVGRV KTYEAIVKGE NIPEPGVPES FKVLIKELQA
1160 1170 1180 1190 1200
LCLDVKVLSD TNEEIKIKES SEEDMEDLGV NIEGTEDEIV PTAEKRSSNQ
1210 1220 1230 1240
DEEALELVDN EEFEDIKLEY DDLQLDELEN GLELEDFNDE H
Length:1,241
Mass (Da):139,720
Last modified:January 9, 2007 - v1
Checksum:i46E1343774DED8C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA. Translation: ABK61102.1.
RefSeqiWP_011721210.1. NC_008593.1.

Genome annotation databases

EnsemblBacteriaiABK61102; ABK61102; NT01CX_1107.
KEGGicno:NT01CX_1107.
PATRICi19477876. VBICloNov112828_0217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000382 Genomic DNA. Translation: ABK61102.1.
RefSeqiWP_011721210.1. NC_008593.1.

3D structure databases

ProteinModelPortaliA0PXT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi386415.NT01CX_1107.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK61102; ABK61102; NT01CX_1107.
KEGGicno:NT01CX_1107.
PATRICi19477876. VBICloNov112828_0217.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Enzyme and pathway databases

BioCyciCNOV386415:GH98-239-MONOMER.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOB_CLONN
AccessioniPrimary (citable) accession number: A0PXT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.