Reviewed, UniProtKB/Swiss-Prot A0PXP9 (HIS2_CLONN)

Names and origin

Protein names

Recommended name:
    Phosphoribosyl-ATP pyrophosphatase
      Short name=PRA-PH
    EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	NT01CX_1067

Organism

Clostridium novyi (strain NT) [Complete proteome] [HAMAP]

Taxonomic identifier

386415 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 110	110	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_1000063337

Sequences

	Sequence		Length	Mass (Da)
	A0PXP9-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: DD6D27438567E93F	FASTA	110	12,894
	10 20 30 40 50 60 MDNIDVIEEL YNVILDRKEN GKENSYTNYL FEKGIDKILK KVGEETTEVI VAAKNTNKDD 70 80 90 100 110 LIAEVCDVIY HMVVLMVEKE VKLEDIKNEL NKRRKKVGNK KPERRKIENI

References

[1]

"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT." Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S. Nat. Biotechnol. 24:1573-1580(2006) [PubMed: 17115055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000382 Genomic DNA. Translation: ABK61603.1.
RefSeq	YP_877151.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4540038.
GenomeReviews	Gene locus NT01CX_1067 in contig CP000382_GR.
KEGG	cno:NT01CX_1067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A0PXP9. GADPDSS.
Family and domain databases
HAMAP	MF_01020. [Tree]
InterPro	IPR008179. PRib-ATP_pyrophosphohydrolase. [Graphical view]
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
ProDom	PD002611. Pra_PH/CH. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03188. histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_CLONN

Accession

Primary (citable) accession number: A0PXP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)