Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A0PXN0

- FTHS_CLONN

UniProt

A0PXN0 - FTHS_CLONN

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium novyi (strain NT)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCNOV386415:GH98-175-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:NT01CX_1042
    OrganismiClostridium novyi (strain NT)
    Taxonomic identifieri386415 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000008220: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300519Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi386415.NT01CX_1042.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PXN0.
    SMRiA0PXN0. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0PXN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSDIEIAQS ANMKKIADIA KELGLGEDDI ELYGKYKCKI SLDVLKNKHN    50
    EADGKLILVT AINPTPAGEG KSTITVGLGQ ALCKLHKKAV IALREPSLGP 100
    VFGIKGGAAG GGYSQVVPME DINLHFTGDM HAITSANNLL AAAIDNHIHQ 150
    GNTLKIDSRR ILFKRVMDMN DRALRHIVVG MGGKVNGFLR EDGFTITVAS 200
    EIMAILCLSN SLMDLKERFG NILVAYNLDG EPIYCKDLNV HGAMAMLMKD 250
    AIKPNLVQTL ENTPAIIHGG PFANIAHGCN SILATKMAMK LGDYAITEAG 300
    FGADLGAEKF LDIKCRYGNL KPDCIVVVAT IRALKHHGGV SKDELSTPDI 350
    EALSKGVSNL QKQIENMKKY GVPVVVAINK FITDSDEEVE FIKEFCDKQG 400
    VEVALAEVWE KGGEGGIALA EKVINVLDTQ KSNFKCLYDE KLSIKEKMDI 450
    IAREIYGASG VDYDKSAEKD IKDIEKLGLD KLPICVAKTQ YSLSDNPSLL 500
    GKPEDFRVNV REVKVSNGAG FIVVLTGNIM TMPGLPKVPA ANKMDILEGG 550
    TIQGLF 556
    Length:556
    Mass (Da):60,126
    Last modified:January 9, 2007 - v1
    Checksum:i8BCA88252C288010
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK61005.1.
    RefSeqiWP_011721153.1. NC_008593.1.
    YP_877132.1. NC_008593.1.

    Genome annotation databases

    EnsemblBacteriaiABK61005; ABK61005; NT01CX_1042.
    GeneIDi4541815.
    KEGGicno:NT01CX_1042.
    PATRICi19477744. VBICloNov112828_0158.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000382 Genomic DNA. Translation: ABK61005.1 .
    RefSeqi WP_011721153.1. NC_008593.1.
    YP_877132.1. NC_008593.1.

    3D structure databases

    ProteinModelPortali A0PXN0.
    SMRi A0PXN0. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 386415.NT01CX_1042.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK61005 ; ABK61005 ; NT01CX_1042 .
    GeneIDi 4541815.
    KEGGi cno:NT01CX_1042.
    PATRICi 19477744. VBICloNov112828_0158.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CNOV386415:GH98-175-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NT.

    Entry informationi

    Entry nameiFTHS_CLONN
    AccessioniPrimary (citable) accession number: A0PXN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3