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A0PWB4 (MPRA_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Response regulator MprA
Alternative name(s):
Mycobacterial persistence regulator A
Gene names
Name:mprA
Ordered Locus Names:MUL_4701
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.

Subcellular location

Cytoplasm Potential.

Post-translational modification

Phosphorylated and dephosphorylated by MprB By similarity.

Sequence similarities

Contains 1 response regulatory domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Response regulator MprA
PRO_0000308429

Regions

Domain4 – 118115Response regulatory

Amino acid modifications

Modified residue4814-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
A0PWB4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: EF0853ACA7D3C835

FASTA23226,041
        10         20         30         40         50         60 
MSVRILVVDD DRAVRESLRR SLSFNGYTVE LAHDGVEALE MIASDRPDAL VLDVMMPRLD 

        70         80         90        100        110        120 
GLEVCRQLRS TGDDLPILVL TARDSVSERV AGLDAGADDY LPKPFALEEL LARMRALLRR 

       130        140        150        160        170        180 
TKLEDDEAAD SVAMTFSDLS LDPVTREVTR GARRISLTRT EFALLEMLIA NPRRVLTRSR 

       190        200        210        220        230 
ILEEVWGFDF PTSGNALEVY VGYLRRKTEA EGEPRLIHTV RGVGYVLRET PP 

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000325 Genomic DNA. Translation: ABL06633.1.
RefSeqYP_908104.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PWB4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362242.MUL_4701.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL06633; ABL06633; MUL_4701.
GeneID4554298.
KEGGmul:MUL_4701.
PATRIC18177263. VBIMycUlc37413_5428.

Organism-specific databases

GenoListMUL_4701.
CMRSearch...

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034815.
KOK07669.
OMADFMGDSN.
OrthoDBEOG6G4VQG.
ProtClustDBCLSK790869.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPRA_MYCUA
AccessionPrimary (citable) accession number: A0PWB4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families