A0PW66 (PTH_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	MUL_4644

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 191	191	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_1000010617

Sequences

	Sequence		Length	Mass (Da)
	A0PW66 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 2E4017A9CCCB8913	FASTA	191	20,714
	10 20 30 40 50 60 MAEPLLVVGL GNPGENYART RHNLGFMVAD LLAARLGAKF KVHKRSGAEV VTGRLAQRSV 70 80 90 100 110 120 VLAKPRCYMN ESGRQVAPLA KFYSVPPADL IVIHDELDLD FGRIRLKFGG GEGGHNGLRS 130 140 150 160 170 180 VAAALGTKNF QRVRIGIGRP PGRKDPATFV LENFSSPERP EVPTICEQAA DATELLVEVG 190 LEPAQNRVHA W

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Agy99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL06585.1.
RefSeq	YP_908056.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PW66.
SMR	A0PW66. Positions 1-191.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PW66.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000075659; EBMYCP00000073664; EBMYCG00000075654.
GeneID	4550815.
GenomeReviews	Gene locus MUL_4644 in contig CP000325_GR.
KEGG	mul:MUL_4644.
PATRIC	18177139. VBIMycUlc37413_5368.
Organism-specific databases
GenoList	MUL_4644.
CMR	Search...
Phylogenomic databases
eggNOG	COG0193.
GeneTree	EBGT00050000017462.
HOGENOM	HBG610927.
OMA	IKFKTGG.
PhylomeDB	A0PW66.
ProtClustDB	PRK05426.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_MYCUA

Accession

Primary (citable) accession number: A0PW66

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program