Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei358Proton donor1
Active sitei3891
Active sitei5151

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:MUL_4416
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000765 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000139911 – 554Glucose-6-phosphate isomeraseAdd BLAST554

Structurei

3D structure databases

ProteinModelPortaliA0PVN7.
SMRiA0PVN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

HOGENOMiHOG000261371.
KOiK01810.
OMAiTNSQHAF.
OrthoDBiPOG091H04C3.

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0PVN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEQPIPDI TATPAWEALR KHHDQIGETH LRQIFADDPN RGHDLTVTVG
60 70 80 90 100
DLYIDYSKHR ITRDTISLLV DLARTANLEA HRDQMFAGAH INTSEDRAVL
110 120 130 140 150
HTALRLPRDA ELIVDGRNVV EDVHAVLDAM GDFTDRLRSG EWTGATGKRI
160 170 180 190 200
STVVNIGIGG SDLGPVMVYQ ALRHYADAGI SARFVSNVDP ADLIATLADL
210 220 230 240 250
DPATTLFIVA SKTFSTLETL TNATAARRWL TDALGDAAVS QHFVAVSTNR
260 270 280 290 300
RLVDDFGINT DNIFGFWDWV GGRYSVDSAI GLSVMAAIGR EAFADFLSGF
310 320 330 340 350
HIVDEHFRTA PPESNAPALL GLIGLWYSNF LGAQSRAVLP YSNDLARFAA
360 370 380 390 400
YLQQLTMESN GKSTRADGTA VTTDTGEIYW GERGTNGQHA FYQLLHQGTR
410 420 430 440 450
LVPADFIGFS QPIDDLPTVE GTGSMHDLLM SNFFAQTQVL AFGKTAEEIA
460 470 480 490 500
AEGTPAAVVP HKVMPGNRPS TSILAKRLTP SVLGQLIAVY EHQVFTEGVV
510 520 530 540 550
WGIDSFDQWG VELGKTQAKA LLPVITSDGS PQRQSDSSTD ALVRRYRTQR

GRTG
Length:554
Mass (Da):60,346
Last modified:January 9, 2007 - v1
Checksum:i72974541F02D75B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA. Translation: ABL06406.1.
RefSeqiWP_011742007.1. NC_008611.1.

Genome annotation databases

EnsemblBacteriaiABL06406; ABL06406; MUL_4416.
KEGGimul:MUL_4416.

Similar proteinsi

Entry informationi

Entry nameiG6PI_MYCUA
AccessioniPrimary (citable) accession number: A0PVN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: November 22, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families