A0PVN7 (G6PI_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	MUL_4416

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 554	554	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000013991
Sites
	Active site	358	1	Proton donor By similarity
	Active site	389	1	By similarity
	Active site	515	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0PVN7 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 72974541F02D75B4	FASTA	554	60,346
	10 20 30 40 50 60 MTSEQPIPDI TATPAWEALR KHHDQIGETH LRQIFADDPN RGHDLTVTVG DLYIDYSKHR 70 80 90 100 110 120 ITRDTISLLV DLARTANLEA HRDQMFAGAH INTSEDRAVL HTALRLPRDA ELIVDGRNVV 130 140 150 160 170 180 EDVHAVLDAM GDFTDRLRSG EWTGATGKRI STVVNIGIGG SDLGPVMVYQ ALRHYADAGI 190 200 210 220 230 240 SARFVSNVDP ADLIATLADL DPATTLFIVA SKTFSTLETL TNATAARRWL TDALGDAAVS 250 260 270 280 290 300 QHFVAVSTNR RLVDDFGINT DNIFGFWDWV GGRYSVDSAI GLSVMAAIGR EAFADFLSGF 310 320 330 340 350 360 HIVDEHFRTA PPESNAPALL GLIGLWYSNF LGAQSRAVLP YSNDLARFAA YLQQLTMESN 370 380 390 400 410 420 GKSTRADGTA VTTDTGEIYW GERGTNGQHA FYQLLHQGTR LVPADFIGFS QPIDDLPTVE 430 440 450 460 470 480 GTGSMHDLLM SNFFAQTQVL AFGKTAEEIA AEGTPAAVVP HKVMPGNRPS TSILAKRLTP 490 500 510 520 530 540 SVLGQLIAVY EHQVFTEGVV WGIDSFDQWG VELGKTQAKA LLPVITSDGS PQRQSDSSTD 550 ALVRRYRTQR GRTG

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Agy99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL06406.1.
RefSeq	YP_907877.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PVN7.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PVN7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000074885; EBMYCP00000072890; EBMYCG00000074880.
GeneID	4549900.
GenomeReviews	Gene locus MUL_4416 in contig CP000325_GR.
KEGG	mul:MUL_4416.
PATRIC	18176633. VBIMycUlc37413_5118.
Organism-specific databases
GenoList	MUL_4416.
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
GeneTree	EBGT00050000016991.
HOGENOM	HBG352954.
OMA	NSLPAWT.
PhylomeDB	A0PVN7.
ProtClustDB	PRK00179.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_MYCUA

Accession

Primary (citable) accession number: A0PVN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program