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A0PVN7

- G6PI_MYCUA

UniProt

A0PVN7 - G6PI_MYCUA

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei358 – 3581Proton donorUniRule annotation
    Active sitei389 – 3891UniRule annotation
    Active sitei515 – 5151UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:MUL_4416
    OrganismiMycobacterium ulcerans (strain Agy99)
    Taxonomic identifieri362242 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000765: Chromosome

    Organism-specific databases

    GenoListiMUL_4416.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554Glucose-6-phosphate isomerasePRO_1000013991Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi362242.MUL_4416.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PVN7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261371.
    KOiK01810.
    OMAiNCHFVAN.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0PVN7-1 [UniParc]FASTAAdd to Basket

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    MTSEQPIPDI TATPAWEALR KHHDQIGETH LRQIFADDPN RGHDLTVTVG    50
    DLYIDYSKHR ITRDTISLLV DLARTANLEA HRDQMFAGAH INTSEDRAVL 100
    HTALRLPRDA ELIVDGRNVV EDVHAVLDAM GDFTDRLRSG EWTGATGKRI 150
    STVVNIGIGG SDLGPVMVYQ ALRHYADAGI SARFVSNVDP ADLIATLADL 200
    DPATTLFIVA SKTFSTLETL TNATAARRWL TDALGDAAVS QHFVAVSTNR 250
    RLVDDFGINT DNIFGFWDWV GGRYSVDSAI GLSVMAAIGR EAFADFLSGF 300
    HIVDEHFRTA PPESNAPALL GLIGLWYSNF LGAQSRAVLP YSNDLARFAA 350
    YLQQLTMESN GKSTRADGTA VTTDTGEIYW GERGTNGQHA FYQLLHQGTR 400
    LVPADFIGFS QPIDDLPTVE GTGSMHDLLM SNFFAQTQVL AFGKTAEEIA 450
    AEGTPAAVVP HKVMPGNRPS TSILAKRLTP SVLGQLIAVY EHQVFTEGVV 500
    WGIDSFDQWG VELGKTQAKA LLPVITSDGS PQRQSDSSTD ALVRRYRTQR 550
    GRTG 554
    Length:554
    Mass (Da):60,346
    Last modified:January 9, 2007 - v1
    Checksum:i72974541F02D75B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000325 Genomic DNA. Translation: ABL06406.1.
    RefSeqiWP_011742007.1. NC_008611.1.
    YP_907877.1. NC_008611.1.

    Genome annotation databases

    EnsemblBacteriaiABL06406; ABL06406; MUL_4416.
    GeneIDi4549900.
    KEGGimul:MUL_4416.
    PATRICi18176633. VBIMycUlc37413_5118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000325 Genomic DNA. Translation: ABL06406.1 .
    RefSeqi WP_011742007.1. NC_008611.1.
    YP_907877.1. NC_008611.1.

    3D structure databases

    ProteinModelPortali A0PVN7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362242.MUL_4416.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL06406 ; ABL06406 ; MUL_4416 .
    GeneIDi 4549900.
    KEGGi mul:MUL_4416.
    PATRICi 18176633. VBIMycUlc37413_5118.

    Organism-specific databases

    GenoListi MUL_4416.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261371.
    KOi K01810.
    OMAi NCHFVAN.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    UPA00138 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
      Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.
      , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
      Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Agy99.

    Entry informationi

    Entry nameiG6PI_MYCUA
    AccessioniPrimary (citable) accession number: A0PVN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3