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A0PVA1 (A0PVA1_MYCUA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123
Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123
Gene names
Name:acs EMBL ABL06270.1
Synonyms:acsA HAMAP MF_01123
Ordered Locus Names:MUL_4241
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length660 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site5331 By similarity HAMAP MF_01123

Amino acid modifications

Modified residue6251N6-acetyllysine By similarity HAMAP MF_01123

Sequences

Sequence LengthMass (Da)Tools
A0PVA1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 995569CAB9538D7D

FASTA66072,247
        10         20         30         40         50         60 
MKLNIGDTPV TATSAEEPSS YPPPAEFIEQ ANARAELYRE AEEDRLAFWA KQADRLSWAT 

        70         80         90        100        110        120 
PFGEVLDWSD APFANWFVGG KLNVAYNCVD RHVEAGNGDR VAIHWVGEPI EDSRTLTYAD 

       130        140        150        160        170        180 
LQAEVSKAAN ALTGLGLVAG DRVAIYLPLI PEAVIAMLAC ARLGIMHSVV FGGFTANTLH 

       190        200        210        220        230        240 
ARIVDAQAKL LITSDGQFRR GHPAPLKDAA DEAVSQPDSP VEHVLVVRRT GIDVSWNDER 

       250        260        270        280        290        300 
DLWWHDVVDS ASPQHTPEPF DAEQPLFLLY TSGTTGKPKG IVHTSGGYLT QCCYTVHTIF 

       310        320        330        340        350        360 
DVKPETDVFW CTADIGWVTG HTYGVYGPLA NGITEVLYEG TPNTPDEHRH FQIIEEYGVT 

       370        380        390        400        410        420 
IYYTAPTLIR TFMKWGRAIP DAHDLSSLRL LGSVGEPINP EAWRWYRDVV GAGHTPIVDT 

       430        440        450        460        470        480 
WWQTETGSAM ISPLPGIAAA KPGSAMTPLP GISAKVVDDH GDPLAPETDE GTHVTGYLVL 

       490        500        510        520        530        540 
DQPWPSMLRG IWGDPARFHY AYWSKFEDKG YYFAGDGARL DSDGAIWVLG RIDDVMNVSG 

       550        560        570        580        590        600 
HRISTAEVES ALVGHPGVAE AAVVGVVDDT TTQAICAFVV LRGNYEQHDG TSEELRAEVA 

       610        620        630        640        650        660 
EAISPIARPR EVHVVPELPK TRSGKIMRRL LRDIAEKREL GDTSTLLDPT VFDAIRNAAK

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References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL06270.1.
RefSeqYP_907741.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PVA1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0PVA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000074558; EBMYCP00000072563; EBMYCG00000074553.
GeneID4551160.
GenomeReviewsGene locus MUL_4241 in contig CP000325_GR.
KEGGmul:MUL_4241.
PATRIC18176212. VBIMycUlc37413_4915.

Organism-specific databases

GenoListMUL_4241.
CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
GeneTreeEBGT00050000015141.
HOGENOMHBG547964.
OMAVISVSGH.
ProtClustDBPRK00174.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0PVA1_MYCUA
AccessionPrimary (citable) accession number: A0PVA1
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info