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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE), GTP cyclohydrolase I FolE_1 (folE_1)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90ZincUniRule annotation1
Metal bindingi93ZincUniRule annotation1
Metal bindingi163ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:MUL_4191
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000765 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001001861 – 202GTP cyclohydrolase 1Add BLAST202

Interactioni

Subunit structurei

Homopolymer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0PV57.
SMRiA0PV57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221222.
KOiK01495.
OMAiVEGEHLC.
OrthoDBiPOG091H01SE.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiView protein in InterPro
IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiView protein in Pfam
PF01227. GTP_cyclohydroI. 1 hit.
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiView protein in PROSITE
PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0PV57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQLDSRTEA TTTRAFDQPR AEAAVRELLL AIGEDPDRGG LRDTPARVAR
60 70 80 90 100
AYREIFAGLY TDPDAVLNTM FDEDHDELVL IKEIPLYSTC EHHLVSFHGV
110 120 130 140 150
AHVGYIPGRD GRVTGLSKIA RLVDLYAKRP QVQERLTSQI ADALVKRLGP
160 170 180 190 200
RGVLVVVEAE HLCMAMRGVR KPGAVTTTSA VRGQFKTDAA SRAEALDLIL

RK
Length:202
Mass (Da):22,273
Last modified:January 9, 2007 - v1
Checksum:i9133F38DAB412DF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA. Translation: ABL06226.1.

Genome annotation databases

EnsemblBacteriaiABL06226; ABL06226; MUL_4191.
KEGGimul:MUL_4191.
PATRICi18176114. VBIMycUlc37413_4867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA. Translation: ABL06226.1.

3D structure databases

ProteinModelPortaliA0PV57.
SMRiA0PV57.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL06226; ABL06226; MUL_4191.
KEGGimul:MUL_4191.
PATRICi18176114. VBIMycUlc37413_4867.

Phylogenomic databases

HOGENOMiHOG000221222.
KOiK01495.
OMAiVEGEHLC.
OrthoDBiPOG091H01SE.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiView protein in InterPro
IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiView protein in Pfam
PF01227. GTP_cyclohydroI. 1 hit.
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiView protein in PROSITE
PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCH1_MYCUA
AccessioniPrimary (citable) accession number: A0PV57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 9, 2007
Last modified: March 15, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.