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A0PUX3 (ACDH2_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase 2

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2
Gene names
Ordered Locus Names:MUL_4096
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Acetaldehyde dehydrogenase 2 HAMAP-Rule MF_01657
PRO_0000387691

Regions

Nucleotide binding12 – 154NAD By similarity
Nucleotide binding162 – 1709NAD By similarity

Sites

Active site1271Acyl-thioester intermediate By similarity
Binding site2811NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A0PUX3 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 5A2F57689B27BDD5

FASTA30832,272
        10         20         30         40         50         60 
MPSKASVAIV GSGNISTDLL YKLLRSDWLE PRWMVGIDPQ SEGLARARKL GLETTHEGVD 

        70         80         90        100        110        120 
WLVAQSDKPD LVFEATSAYV HKAAAPKYAA AGIRAIDLTP AAVGPAVVPP ANLREHLDAP 

       130        140        150        160        170        180 
NVNMITCGGQ ATIPIVYAVS RAVADLGGVP YAEIVASVAS VSAGPGTRAN IDEFTKTTSK 

       190        200        210        220        230        240 
GVETIGGARR GKAIIILNPA DPPMIMRDTI FCAIPEDADR DAIAASIHEV VAQVQTYVPG 

       250        260        270        280        290        300 
YRLLNEPQFD EPSINSGGQA VVTTFVEVEG AGDYLPPYAG NLDIMTAAAT KVGEEIAKET 


LAVSGGKR 

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000325 Genomic DNA. Translation: ABL06142.1.
RefSeqYP_907613.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PUX3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362242.MUL_4096.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL06142; ABL06142; MUL_4096.
GeneID4551371.
KEGGmul:MUL_4096.
PATRIC18175898. VBIMycUlc37413_4760.

Organism-specific databases

GenoListMUL_4096.
CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAHLKHAPL.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH2_MYCUA
AccessionPrimary (citable) accession number: A0PUX3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 9, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families