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A0PUL4 (KHSE_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:MUL_3968
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384

Subcellular location

Cytoplasm Potential HAMAP MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Homoserine kinase HAMAP MF_00384
PRO_1000049151

Regions

Nucleotide binding95 – 10511ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A0PUL4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 6E2F6A1C977205FE

FASTA31432,631
        10         20         30         40         50         60 
MTQVLPSGLV ASAVVAASSA NLGPGFDSLG LALSLYDEIV LETTDSGLEV VVEGEGAGQV 

        70         80         90        100        110        120 
PLNSEHLVVR AIQHGLRAVG VPATGLIVRC RNDIPHSRGL GSSASAVVGG LAAVNGLVSQ 

       130        140        150        160        170        180 
AGWVPLSDQQ LIQLSSEFEG HPDNAAAAVL GGAVVSWIER CGDRADYSAV QLDLHPDIHL 

       190        200        210        220        230        240 
FSAIPEVRSS TAETRVLLPD LVSHDDARFN ISRAALLVVA LTQRPDLLMA ATEDVLHQPQ 

       250        260        270        280        290        300 
RASAMPASAE YLQLLRRHKV AATLSGAGPA LIALTTNPDL PPEAVEYGAA NGFTITAMTA 

       310 
GDRVRWKPGV AFSD

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL06033.1.
RefSeqYP_907504.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PUL4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0PUL4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000073628; EBMYCP00000071633; EBMYCG00000073623.
GeneID4552604.
GenomeReviewsGene locus MUL_3968 in contig CP000325_GR.
KEGGmul:MUL_3968.
PATRIC18175614. VBIMycUlc37413_4619.

Organism-specific databases

GenoListMUL_3968.
CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
GeneTreeEBGT00050000016145.
HOGENOMHBG646290.
OMADRLHQPY.
PhylomeDBA0PUL4.
ProtClustDBPRK01212.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_MYCUA
AccessionPrimary (citable) accession number: A0PUL4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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