A0PUH6 (MURI_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate racemase
EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	MUL_3925

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Glutamate racemase HAMAP MF_00258		PRO_1000047588

Sequences

	Sequence		Length	Mass (Da)
	A0PUH6 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: EF52CCFE8A220C3E	FASTA	271	28,574
	10 20 30 40 50 60 MSSPLAPVGI FDSGVGGLTV ARAIIDQLPD EDIVYVGDTG NGPYGPLTIP EVRAHALAIG 70 80 90 100 110 120 DDLVGRGVKA LVIACNTASA ACLRDARERY DVPVVEVILP AVRRAVATTR NGRIGVIGTR 130 140 150 160 170 180 ATITSHAYQD AFAAARDTEI TAVACPRFVD FVERGVTSGR QVLGLAEGYL EPLQRSGVDT 190 200 210 220 230 240 LVLGCTHYPL LSGLIQLVMG DNVTLVSSAE ETAKEVLRVL TERDILRPHD APPATRLFEA 250 260 270 TGDPEAFMAL AARFLGPALT GVQPVRPSGM H

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Agy99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL05995.1.
RefSeq	YP_907466.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PUH6.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PUH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000073595; EBMYCP00000071600; EBMYCG00000073590.
GeneID	4553594.
GenomeReviews	Gene locus MUL_3925 in contig CP000325_GR.
KEGG	mul:MUL_3925.
PATRIC	18175520. VBIMycUlc37413_4575.
Organism-specific databases
GenoList	MUL_3925.
CMR	Search...
Phylogenomic databases
eggNOG	COG0796.
GeneTree	EBGT00050000016063.
HOGENOM	HBG645102.
OMA	PQEDTIY.
PhylomeDB	A0PUH6.
ProtClustDB	PRK00865.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
KO	K01776.
PANTHER	PTHR21198. PTHR21198. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
SUPFAM	SSF53681. Asp/Glu_race. 2 hits.
TIGRFAMs	TIGR00067. Glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_MYCUA

Accession

Primary (citable) accession number: A0PUH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program