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A0PTC0 (DNLI_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:MUL_3413
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513Probable DNA ligase HAMAP-Rule MF_00407
PRO_0000365233

Sites

Active site2171N6-AMP-lysine intermediate By similarity
Binding site2151ATP By similarity
Binding site2221ATP By similarity
Binding site2371ATP By similarity
Binding site2661ATP By similarity
Binding site3061ATP By similarity
Binding site3781ATP By similarity
Binding site3841ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A0PTC0 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: E9004DEE06F58F4C

FASTA51353,686
        10         20         30         40         50         60 
MLLIDIASTS LNVGGTSSRL AKVARIAEPL RAAAPDPELV AIVVAWLSGE LRQRQIGVGW 

        70         80         90        100        110        120 
ATLRSPPAAA GSPALTVTGT DAAFSEIGAV SGKGSAARRR ELITRLFAAS TETEQAFLVR 

       130        140        150        160        170        180 
LLSGELRQGA LAGIMVDAVA RAAEVPATAV QRAAMLGGDL PTVAAACLAA GSSGAAGALD 

       190        200        210        220        230        240 
SFTLRVGRPI GPMLAQSAGS ITDALERHGG ATIFEAKLDG ARVQIHRTGD EVTVYTRSLD 

       250        260        270        280        290        300 
DVTARLPEVV QATLALPVSD LVADGEAIAL QPDGRPHRFQ VTASRFGRSV NVAAAQAKQP 

       310        320        330        340        350        360 
LSVFFSDILH RDGRDLLDAP TTDRLAALDA VVPARHRVDR LTTADAAAAT DFLRATLAAG 

       370        380        390        400        410        420 
HEGVMAKSPT APYLAGRRGA GWLKVKPVHT LDLVVLAVEW GSGRRRGKLS NIPLGARDAA 

       430        440        450        460        470        480 
TGEFVMLGKT FKSMTDAMLD WQTARFTELA VGGTDGYVVA LRPEQVVEVA FDGVQASSRY 

       490        500        510 
PGGLALRFAR VVRYRDDKGP ADADTIDTVR ALY 

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000325 Genomic DNA. Translation: ABL05589.1.
RefSeqYP_907060.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PTC0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362242.MUL_3413.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL05589; ABL05589; MUL_3413.
GeneID4554091.
KEGGmul:MUL_3413.
PATRIC18174281. VBIMycUlc37413_3969.

Organism-specific databases

GenoListMUL_3413.
CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMAGRPRPFQ.
OrthoDBEOG6Q8HXT.
ProtClustDBPRK03180.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_MYCUA
AccessionPrimary (citable) accession number: A0PTC0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 9, 2007
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families