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A0PTC0

- DNLI_MYCUA

UniProt

A0PTC0 - DNLI_MYCUA

Protein

Probable DNA ligase

Gene

lig

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei215 – 2151ATPUniRule annotation
    Active sitei217 – 2171N6-AMP-lysine intermediateUniRule annotation
    Binding sitei222 – 2221ATPUniRule annotation
    Binding sitei237 – 2371ATPUniRule annotation
    Binding sitei266 – 2661ATPUniRule annotation
    Binding sitei306 – 3061ATPUniRule annotation
    Binding sitei378 – 3781ATPUniRule annotation
    Binding sitei384 – 3841ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:MUL_3413
    OrganismiMycobacterium ulcerans (strain Agy99)
    Taxonomic identifieri362242 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000765: Chromosome

    Organism-specific databases

    GenoListiMUL_3413.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Probable DNA ligasePRO_0000365233Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi362242.MUL_3413.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PTC0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiARVQVHK.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0PTC0-1 [UniParc]FASTAAdd to Basket

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    MLLIDIASTS LNVGGTSSRL AKVARIAEPL RAAAPDPELV AIVVAWLSGE    50
    LRQRQIGVGW ATLRSPPAAA GSPALTVTGT DAAFSEIGAV SGKGSAARRR 100
    ELITRLFAAS TETEQAFLVR LLSGELRQGA LAGIMVDAVA RAAEVPATAV 150
    QRAAMLGGDL PTVAAACLAA GSSGAAGALD SFTLRVGRPI GPMLAQSAGS 200
    ITDALERHGG ATIFEAKLDG ARVQIHRTGD EVTVYTRSLD DVTARLPEVV 250
    QATLALPVSD LVADGEAIAL QPDGRPHRFQ VTASRFGRSV NVAAAQAKQP 300
    LSVFFSDILH RDGRDLLDAP TTDRLAALDA VVPARHRVDR LTTADAAAAT 350
    DFLRATLAAG HEGVMAKSPT APYLAGRRGA GWLKVKPVHT LDLVVLAVEW 400
    GSGRRRGKLS NIPLGARDAA TGEFVMLGKT FKSMTDAMLD WQTARFTELA 450
    VGGTDGYVVA LRPEQVVEVA FDGVQASSRY PGGLALRFAR VVRYRDDKGP 500
    ADADTIDTVR ALY 513
    Length:513
    Mass (Da):53,686
    Last modified:January 9, 2007 - v1
    Checksum:iE9004DEE06F58F4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000325 Genomic DNA. Translation: ABL05589.1.
    RefSeqiWP_011741196.1. NC_008611.1.
    YP_907060.1. NC_008611.1.

    Genome annotation databases

    EnsemblBacteriaiABL05589; ABL05589; MUL_3413.
    GeneIDi4554091.
    KEGGimul:MUL_3413.
    PATRICi18174281. VBIMycUlc37413_3969.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000325 Genomic DNA. Translation: ABL05589.1 .
    RefSeqi WP_011741196.1. NC_008611.1.
    YP_907060.1. NC_008611.1.

    3D structure databases

    ProteinModelPortali A0PTC0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362242.MUL_3413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL05589 ; ABL05589 ; MUL_3413 .
    GeneIDi 4554091.
    KEGGi mul:MUL_3413.
    PATRICi 18174281. VBIMycUlc37413_3969.

    Organism-specific databases

    GenoListi MUL_3413.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi ARVQVHK.
    OrthoDBi EOG6Q8HXT.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
      Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.
      , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
      Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Agy99.

    Entry informationi

    Entry nameiDNLI_MYCUA
    AccessioniPrimary (citable) accession number: A0PTC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3