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Protein

Probable DNA ligase

Gene

lig

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei215ATPUniRule annotation1
Active sitei217N6-AMP-lysine intermediateUniRule annotation1
Binding sitei222ATPUniRule annotation1
Binding sitei237ATPUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei378ATPUniRule annotation1
Binding sitei384ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:MUL_3413
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000765 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652331 – 513Probable DNA ligaseAdd BLAST513

Proteomic databases

PRIDEiA0PTC0

Structurei

3D structure databases

ProteinModelPortaliA0PTC0
SMRiA0PTC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A0PTC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLIDIASTS LNVGGTSSRL AKVARIAEPL RAAAPDPELV AIVVAWLSGE
60 70 80 90 100
LRQRQIGVGW ATLRSPPAAA GSPALTVTGT DAAFSEIGAV SGKGSAARRR
110 120 130 140 150
ELITRLFAAS TETEQAFLVR LLSGELRQGA LAGIMVDAVA RAAEVPATAV
160 170 180 190 200
QRAAMLGGDL PTVAAACLAA GSSGAAGALD SFTLRVGRPI GPMLAQSAGS
210 220 230 240 250
ITDALERHGG ATIFEAKLDG ARVQIHRTGD EVTVYTRSLD DVTARLPEVV
260 270 280 290 300
QATLALPVSD LVADGEAIAL QPDGRPHRFQ VTASRFGRSV NVAAAQAKQP
310 320 330 340 350
LSVFFSDILH RDGRDLLDAP TTDRLAALDA VVPARHRVDR LTTADAAAAT
360 370 380 390 400
DFLRATLAAG HEGVMAKSPT APYLAGRRGA GWLKVKPVHT LDLVVLAVEW
410 420 430 440 450
GSGRRRGKLS NIPLGARDAA TGEFVMLGKT FKSMTDAMLD WQTARFTELA
460 470 480 490 500
VGGTDGYVVA LRPEQVVEVA FDGVQASSRY PGGLALRFAR VVRYRDDKGP
510
ADADTIDTVR ALY
Length:513
Mass (Da):53,686
Last modified:January 9, 2007 - v1
Checksum:iE9004DEE06F58F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA Translation: ABL05589.1

Genome annotation databases

EnsemblBacteriaiABL05589; ABL05589; MUL_3413
KEGGimul:MUL_3413

Similar proteinsi

Entry informationi

Entry nameiDNLI_MYCUA
AccessioniPrimary (citable) accession number: A0PTC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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