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A0PSX2 (DER_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTPase Der
Alternative name(s):
GTP-binding protein EngA
Gene names
Name:der
Synonyms:engA
Ordered Locus Names:MUL_3232
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP MF_00195

Subunit structure

Associates with the 50S ribosomal subunit By similarity.

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Der subfamily.

Contains 2 G (guanine nucleotide-binding) domains.

Contains 1 KH-like domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   DomainRepeat
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469GTPase Der HAMAP MF_00195
PRO_1000011673

Regions

Domain41 – 146106G 1
Domain214 – 322109G 2
Domain376 – 45984KH-like
Nucleotide binding36 – 438GTP 1 Potential
Nucleotide binding83 – 875GTP 1 Potential
Nucleotide binding145 – 1484GTP 1 Potential
Nucleotide binding209 – 2168GTP 2 Potential
Nucleotide binding256 – 2605GTP 2 Potential
Nucleotide binding321 – 3244GTP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
A0PSX2 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 7B0A51D945792FA6

FASTA46950,870
        10         20         30         40         50         60 
MTQDGTWSDE SDWELDDADL ADLAEAAPAP VLAIVGRPNV GKSTLVNRIL GRREAVVQDI 

        70         80         90        100        110        120 
PGVTRDRVSY DALWNGRRFV VQDTGGWEPD AKGLQQLVAE QASVAMRTAD AVVLVVDATV 

       130        140        150        160        170        180 
GATTADEAAA RILLRSGKPV FLAANKVDSD KAEADAATLW SMGLGEPHAI SAMHGRGVAN 

       190        200        210        220        230        240 
LLDTVLKKLP EVAESVSAGG GPRRVALVGK PNVGKSSLLN KLAGDERSVV HDVAGTTVDP 

       250        260        270        280        290        300 
VDSLIELGGK VWRFVDTAGL RRKVGQASGH EFYASVRTRG AIDAAEVVVL LIDASQPLTE 

       310        320        330        340        350        360 
QDLRVLSMVI EAGRAVVLAY NKWDLVDEDR RDLLDREIDR ELVQIRWAQR VNISAKTGRA 

       370        380        390        400        410        420 
VQKLVPAMET ALASWDTRIP TGPLNSWIKE VVAATPPPVR GGKQPRILFA TQATARPPTF 

       430        440        450        460 
VLFTTGFLEA GYRRFLERRL RETFGFEGSP IRINVRVREK RGAKRPGRR

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL05441.1.
RefSeqYP_906912.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PSX2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0PSX2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000073344; EBMYCP00000071349; EBMYCG00000073339.
GeneID4554209.
GenomeReviewsGene locus MUL_3232 in contig CP000325_GR.
KEGGmul:MUL_3232.
PATRIC18173871. VBIMycUlc37413_3767.

Organism-specific databases

GenoListMUL_3232.
CMRSearch...

Phylogenomic databases

eggNOGCOG1160.
GeneTreeEBGT00050000016947.
HOGENOMHBG592135.
OMALAVNKCE.
ProtClustDBPRK03003.

Family and domain databases

HAMAPMF_00195. GTPase_Der.
[Tree]
InterProIPR003593. ATPase_AAA+_core.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
Gene3DG3DSA:3.30.300.20. KH_prok. 1 hit.
KOK03977.
PANTHERPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSPR00326. GTP1OBG.
SMARTSM00382. AAA. 2 hits.
[Graphical view]
TIGRFAMsTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. Small_GTP. 2 hits.
ProtoNetSearch...

Entry information

Entry nameDER_MYCUA
AccessionPrimary (citable) accession number: A0PSX2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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