Reviewed, UniProtKB/Swiss-Prot A0PST9 (GABD2_MYCUA)

Names and origin

Protein names

Recommended name:
    Putative succinate-semialdehyde dehydrogenase [NADP+] 2
      Short name=SSADH 2
      Short name=SSDH 2
    EC=1.2.1.16

Gene names

Name:	gabD2
Ordered Locus Names:	MUL_3190

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s) By similarity.
Catalytic activity	Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Putative succinate-semialdehyde dehydrogenase [NADP+] 2		PRO_0000310713
Regions
	Nucleotide binding	232 – 237	6	NAD or NADP By similarity
Sites
	Active site	254	1	By similarity
	Active site	288	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0PST9-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 06E2D6FEC9A43F01	FASTA	518	55,236
	10 20 30 40 50 60 MPVPSSAVFE CLLSLAAIKD VDARPTRTID EVFTGKPLTT IPVGTAEDVE AAFAEAREAQ 70 80 90 100 110 120 ANWAKRPVSE RAEVIRRYRD LVIENREFLM DLLQAEAGKA RWAAQEEVVD LVANANYYAR 130 140 150 160 170 180 VSAGLLKPRT VQALLPGIGK TTVGYQPKGV VGVISPWNYP MTLTASDSVP ALIAGNAVVL 190 200 210 220 230 240 KPDSQTPYCA LACAELLYRA GLPRALYAIV PGPGSVVGTA IADNCDYLMF TGSSATGSRL 250 260 270 280 290 300 AERAGRRLIG FSAELGGKNA MIVTRGVNLD KVAKAATRAC FSNAGQLCIS IERIYVEKDI 310 320 330 340 350 360 ADEFTRKFGD AVRSMKLGTA YDFSVDMGSL ISEGQLKTVS GHVDDATAKG AKVIAGGKAR 370 380 390 400 410 420 PDVGPLFYEP TVLTDVTHEM ECADNETFGP LVSIYPVADV EEAVEKANDT EYGLNASVWA 430 440 450 460 470 480 GSTPEGEKIA ARLRSGTVNV NEGYAFAWGS LSAPMGGMGI SGVGRRHGPE GLLKYTESQT 490 500 510 IATARVFNLD PPMGVPPTLW QKSLLPIVRT VMKLPGRK

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000325 Genomic DNA. Translation: ABL05408.1.
RefSeq	YP_906879.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4554117.
GenomeReviews	Gene locus MUL_3190 in contig CP000325_GR.
KEGG	mul:MUL_3190.
Organism-specific databases
BuruList	MUL_3190.
CMR	Search...
Phylogenomic databases
OMA	A0PST9. DTEYGLN.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD2_MYCUA

Accession

Primary (citable) accession number: A0PST9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)