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A0PST9 (GABD2_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative succinate-semialdehyde dehydrogenase [NADP+] 2
Short name=SSADH 2
Short name=SSDH 2
EC=1.2.1.79
Gene names
Name:gabD2
Ordered Locus Names:MUL_3190
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdehyde dehydrogenase activity, is likely to act physiologically on a different aldehyde(s) By similarity.

Catalytic activity

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Putative succinate-semialdehyde dehydrogenase [NADP+] 2
PRO_0000310713

Regions

Nucleotide binding157 – 1582NADP By similarity
Nucleotide binding181 – 1844NADP By similarity
Nucleotide binding232 – 2332NADP By similarity

Sites

Active site2541Proton acceptor By similarity
Active site2881Nucleophile By similarity
Binding site2551NADP; via carbonyl oxygen By similarity
Binding site3861NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
A0PST9 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 06E2D6FEC9A43F01

FASTA51855,236
        10         20         30         40         50         60 
MPVPSSAVFE CLLSLAAIKD VDARPTRTID EVFTGKPLTT IPVGTAEDVE AAFAEAREAQ 

        70         80         90        100        110        120 
ANWAKRPVSE RAEVIRRYRD LVIENREFLM DLLQAEAGKA RWAAQEEVVD LVANANYYAR 

       130        140        150        160        170        180 
VSAGLLKPRT VQALLPGIGK TTVGYQPKGV VGVISPWNYP MTLTASDSVP ALIAGNAVVL 

       190        200        210        220        230        240 
KPDSQTPYCA LACAELLYRA GLPRALYAIV PGPGSVVGTA IADNCDYLMF TGSSATGSRL 

       250        260        270        280        290        300 
AERAGRRLIG FSAELGGKNA MIVTRGVNLD KVAKAATRAC FSNAGQLCIS IERIYVEKDI 

       310        320        330        340        350        360 
ADEFTRKFGD AVRSMKLGTA YDFSVDMGSL ISEGQLKTVS GHVDDATAKG AKVIAGGKAR 

       370        380        390        400        410        420 
PDVGPLFYEP TVLTDVTHEM ECADNETFGP LVSIYPVADV EEAVEKANDT EYGLNASVWA 

       430        440        450        460        470        480 
GSTPEGEKIA ARLRSGTVNV NEGYAFAWGS LSAPMGGMGI SGVGRRHGPE GLLKYTESQT 

       490        500        510 
IATARVFNLD PPMGVPPTLW QKSLLPIVRT VMKLPGRK

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL05408.1.
RefSeqYP_906879.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PST9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0PST9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000074909; EBMYCP00000072914; EBMYCG00000074904.
GeneID4554117.
GenomeReviewsGene locus MUL_3190 in contig CP000325_GR.
KEGGmul:MUL_3190.
PATRIC18173773. VBIMycUlc37413_3719.

Organism-specific databases

GenoListMUL_3190.
CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
GeneTreeEBGT00050000015660.
HOGENOMHBG752218.
OMAGPLVSIY.
ProtClustDBPRK09407.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00135.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGABD2_MYCUA
AccessionPrimary (citable) accession number: A0PST9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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