Reviewed, UniProtKB/Swiss-Prot A0PSD4 (AHPD_MYCUA)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	MUL_3000

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Subunit structure	Homotrimer By similarity. HAMAP MF_01676
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359501
Sites
	Active site	130	1	Proton donor By similarity
	Active site	133	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	130 ↔ 133		Alternate By similarity
	Disulfide bond	133		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0PSD4-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: ACE377FD32410516	FASTA	178	18,681
	10 20 30 40 50 60 MSIENLKAAL PEYAKDLKLN LGSISRTTVL DEEQLWGTLL ASAAATRNAQ VLAEIGAEAA 70 80 90 100 110 120 DNLSAQAYQA ALGAVSIMGM NNVFYRGRGF LEGQYDDLRA GLRMNIIANP GVDKANFELW 130 140 150 160 170 SFAVSSVNGC SHCVVAHEHT LREAGVGREA VFEALKAAAI VCGVAQALTA AQTLAAVG

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL05253.1.
RefSeq	YP_906724.1.
3D structure databases
SMR	A0PSD4. Positions 2-175.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PSD4.
Protein family/group databases
PeroxiBase	4580. MuAhpD.
Genome annotation databases
GeneID	4553611.
GenomeReviews	Gene locus MUL_3000 in contig CP000325_GR.
KEGG	mul:MUL_3000.
Organism-specific databases
BuruList	MUL_3000.
CMR	Search...
Phylogenomic databases
eggNOG	COG2128.
HOGENOM	HBG414634.
OMA	RAGLRMN.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_MYCUA

Accession

Primary (citable) accession number: A0PSD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	January 9, 2007
Last modified:	February 9, 2010
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)