A0PSA3 (DTD_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-tyrosyl-tRNA(Tyr) deacylase
EC=3.1.-.-

Gene names

Name:	dtd
Ordered Locus Names:	MUL_2960

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium ulcerans

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine By similarity. HAMAP-Rule MF_00518
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the DTD family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-amino acid catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 143	143	D-tyrosyl-tRNA(Tyr) deacylase HAMAP-Rule MF_00518		PRO_1000050858
Sites
	Active site	78	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0PSA3 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: D6A504AD9B53F251	FASTA	143	15,128
	10 20 30 40 50 60 MRVLVQRVCS AAVTVDGDVV GAVRPPGQGL LAFVGVTHGD DGDKARRLAE KLWYLRILTD 70 80 90 100 110 120 EKSASDLGAP ILVVSQFTLY ADTVKGRRPS WNAAAPRAVA EPLVAAFAEA LRALGAHVEA 130 140 GVFGAHMQVE LINDGPVTVM LEL

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Agy99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL05222.1.
RefSeq	YP_906693.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PSA3.
ModBase	Search...
Protein-protein interaction databases
STRING	362242.MUL_2960.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABL05222; ABL05222; MUL_2960.
GeneID	4553435.
KEGG	mul:MUL_2960.
PATRIC	18173227. VBIMycUlc37413_3450.
Organism-specific databases
GenoList	MUL_2960.
CMR	Search...
Phylogenomic databases
eggNOG	COG1490.
HOGENOM	HOG000113982.
KO	K07560.
OMA	DGPVTIW.
ProtClustDB	PRK05273.
Family and domain databases
Gene3D	3.50.80.10. 1 hit.
HAMAP	MF_00518. Tyr_Deacylase_Dtd.
InterPro	IPR023509. DTD-like_dom. IPR003732. DTyrtRNA_deacyls. [Graphical view]
PANTHER	PTHR10472. PTHR10472. 1 hit.
Pfam	PF02580. Tyr_Deacylase. 1 hit. [Graphical view]
SUPFAM	SSF69500. DTyrtRNA_deacyls. 1 hit.
TIGRFAMs	TIGR00256. TIGR00256. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DTD_MYCUA

Accession

Primary (citable) accession number: A0PSA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program