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A0PRP4 (A0PRP4_MYCUA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoadenosine phosphosulfate reductase 1 HAMAP MF_00063
EC=1.8.4.8 HAMAP MF_00063
Alternative name(s):
3'-phosphoadenylylsulfate reductase 1 HAMAP MF_00063
PAPS reductase, thioredoxin dependent 1 HAMAP MF_00063
PAPS sulfotransferase 1 HAMAP MF_00063
PAdoPS reductase 1 HAMAP MF_00063
Gene names
Name:cysH_1 EMBL ABL05013.1
Synonyms:cysH1 HAMAP MF_00063
Ordered Locus Names:MUL_2696
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduction of activated sulfate into sulfite By similarity. HAMAP MF_00063 SAAS SAAS002500

Catalytic activity

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin. HAMAP MF_00063 SAAS SAAS002500

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3. HAMAP MF_00063 SAAS SAAS002500

Subcellular location

Cytoplasm By similarity HAMAP MF_00063 SAAS SAAS002500.

Sequence similarities

Belongs to the PAPS reductase family. CysH subfamily. HAMAP MF_00063

Sequences

Sequence LengthMass (Da)Tools
A0PRP4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: AE2C3399A3E1D15C

FASTA24426,748
        10         20         30         40         50         60 
MSDQPNETQL RELAARGAAE MEGASATDLL RWADEHFGGI NGPRGWATCN YVVASNMQDA 

        70         80         90        100        110        120 
VLIDLASKVR PGVPVIFLDT GYHFAETIGT RDAIEAVYDI RVLNISPEHT VAEQDKLLGK 

       130        140        150        160        170        180 
DLFARDPNEC CRLRKVVPLT NALRGYAAWI TGLRRVESPT RANAPVISFD EAFKLVKINP 

       190        200        210        220        230        240 
LVAWTDQDVQ DYIQSNNVLV NPLVDEGYPS IGCAPCTAKP AVGEDPRSGR WRGRTKTECG 


LHAS

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References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL05013.1.
RefSeqYP_906484.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PRP4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0PRP4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000077206; EBMYCP00000075211; EBMYCG00000077201.
GeneID4549696.
GenomeReviewsGene locus MUL_2696 in contig CP000325_GR.
KEGGmul:MUL_2696.
PATRIC18172626. VBIMycUlc37413_3151.

Organism-specific databases

GenoListMUL_2696.
CMRSearch...

Phylogenomic databases

eggNOGCOG0175.
GeneTreeEBGT00050000017137.
HOGENOMHBG758022.
OMAFEETLAY.
PhylomeDBA0PRP4.
ProtClustDBPRK02090.

Family and domain databases

HAMAPMF_00063. CysH.
[Tree]
InterProIPR011798. APS_reductase.
IPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK00390.
PfamPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsTIGR02055. APS_reductase. 1 hit.
TIGR00434. CysH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0PRP4_MYCUA
AccessionPrimary (citable) accession number: A0PRP4
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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